A5063775987- Crystal Structures and Properties
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Chemical Synthesis and Characterization
- Mineralogy and Gemology Studies
- Advanced NMR Techniques and Applications
- Clay minerals and soil interactions
- Solid-state spectroscopy and crystallography
- Zeolite Catalysis and Synthesis
- Geological and Geochemical Analysis
- Atomic and Subatomic Physics Research
- Radioactive element chemistry and processing
- Nuclear materials and radiation effects
- Inorganic Fluorides and Related Compounds
- Thermal and Kinetic Analysis
- Electron Spin Resonance Studies
- Crystal structures of chemical compounds
- Crystallography and molecular interactions
- Chemical Thermodynamics and Molecular Structure
- Layered Double Hydroxides Synthesis and Applications
- Energetic Materials and Combustion
- Glass properties and applications
- Synthesis and Reactions of Organic Compounds
- Fluorine in Organic Chemistry
- Synthesis of heterocyclic compounds
Institute of Problems of Chemical Physics
2015-2025
Lomonosov Moscow State University
2013-2025
Russian Academy of Sciences
2008-2025
International Tomography Center
2018-2024
Novosibirsk State University
2013-2024
St Petersburg University
2013-2024
University Medical Center
2024
Kiel University
2024
Moscow State University
2023
Vinogradov Institute of Geochemistry
2021
Hyperpolarized
We present an integrated, open-source device for parahydrogen-based hyperpolarization processes in the microtesla field regime with a cost of components less than $7000. The is designed to produce batch 13C and 15N hyperpolarized (HP) compounds via hydrogenative or non-hydrogenative parahydrogen-induced polarization methods that employ magnetic fields efficient transfer parahydrogen-derived spin order X-nuclei (e.g., 15N). apparatus employs layered structure (reminiscent Russian doll...
Abstract The new eudialyte-group mineral amableite-(Ce), ideally Na 15 [(Ce 1.5 )Mn 3 ]Mn 2 Zr □Si[Si 24 O 69 (OH) ](OH) ⋅H O, was discovered in a peralkaline pegmatite at Saint-Amable Sill, Montérégie, Québec, Canada. associated minerals are albite, microcline, aegirine, serandite, natrolite, yofortierite, and an unidentified titanosilicate forming minute grains. Amableite-(Ce) occurs as yellow equant or thick tabular crystals up to mm across. observed crystal forms {0001}; the subordinate...
The NMR hyperpolarization of uniformly
Nimorazole belongs to the imidazole-based family of antibiotics fight against anaerobic bacteria. Moreover, nimorazole is now in Phase 3 clinical trial Europe for potential use as a hypoxia radiosensitizer treatment head and neck cancers. We envision [
The presence of<sup>14</sup>N nucleus in the scalar coupling network results a 3-fold decrease of<sup>15</sup>N<italic>T</italic><sub>1</sub>and polarization values for all<sup>15</sup>N sites in<sup>15</sup>N<sub>2</sub>-metronidazole<italic>versus</italic><sup>15</sup>N<sub>3</sub>-metronidazole SABRE hyperpolarization microtesla fields.
13C hyperpolarized pyruvate is an emerging MRI contrast agent for sensing molecular events in cancer and other diseases with aberrant metabolic pathways. This can be produced via several hyperpolarization techniques. Despite remarkable success research settings, widespread clinical adoption faces substantial roadblocks because the current technology utilized to sense this requires excitation of nuclear spins that also need synchronized field gradient pulses. Here, we demonstrate allyl...
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Abstract The crystal structure of the highly hydrous analogue K-rich gismondine-Sr from Bellerberg paleovolcano, Eifel Mountains, Germany, was studied by single-crystal X-ray diffraction. Electron microprobe analyses (energy-dispersive spectroscopy analyses) provided empirical formula Sr 1.86 Ca 1.13 Ba 0.02 K 1.47 Na 0.48 (Al 7.79 Fe 0.13 Si 8.08 O 32.025 )·14.97H 2 O. mineral is orthorhombic, space group P 1 2, a = 14.1790(2), b 10.6062(2), c 13.8989(2) Å, V 2090.19(6) Å 3 and Z 2. ( R...
Signal Amplification By Reversible Exchange (SABRE) is a new and rapidly developing hyperpolarization technique. The recent discovery of Spin-Lock Induced Crossing SABRE (SLIC-SABRE) showed that high field transfer techniques developed so far were optimized for singlet spin order does not coincide with the experimentally produced state. Here, we investigated SLIC-SABRE approach most advanced quantitative theoretical model to date. Our goal achieve highest possible polarization at using...
Magnetic Resonance Imaging (MRI) is a powerful non-invasive diagnostic method extensively used in biomedical studies. A significant limitation of MRI its relatively low signal-to-noise ratio, which can be increased by hyperpolarizing nuclear spins. One promising Signal Amplification By Reversible Exchange (SABRE), employs parahydrogen as source hyperpolarization. Recent studies demonstrated the feasibility to improve sensitivity with this hyperpolarization technique. Hyperpolarized
Hyperpolarized forms of 1-13C-acetates and 1-13C-pyruvates are used as diagnostic contrast agents for molecular imaging many diseases disorders. Here, we report the synthetic preparation 1-13C isotopically enriched pure from solvent acetates pyruvates derivatized with unsaturated ester moiety. The reported precursors can be employed NMR hyperpolarization via parahydrogen-induced polarization (PHIP). In this PHIP variant, Side arm hydrogenation (SAH) moiety is followed by transfer nascent...
Among the hyperpolarization techniques geared toward in vivo magnetic resonance imaging, parahydrogen-induced polarization (PHIP) shows promise due to its low cost and fast speed of contrast agent preparation. The synthesis 13C-labeled, unsaturated precursors perform PHIP by side arm hydrogenation has recently opened new possibilities for metabolic imaging owing biological compatibility reaction products, although transfer between parahydrogen-derived protons 13C heteronucleus must yet be...
Abstract One of the essential themes in modern catalysis is that bridging gap between its homogeneous and heterogeneous counterparts to combine their individual advantages overcome shortcomings. more incentive can now be added list, namely ability transition metal complexes provide strong nuclear magnetic resonance (NMR) signal enhancement upon use hydrogenations unsaturated compounds with parahydrogen solution. The addition both H atoms a molecule same substrate, prerequisite for such...
Parahydrogen-induced polarization of 13C nuclei by side-arm hydrogenation (PHIP-SAH) for [1-13C]acetate and [1-13C]pyruvate esters with application PH-INEPT-type pulse sequences 1H to transfer is reported, its efficiency compared that based on magnetic field cycling (MFC). The pulse-sequence approach may have merits in some applications because the entire hyperpolarization procedure implemented directly an NMR or MRI instrument, whereas MFC requires a controlled variation at low fields....
The thermal decomposition kinetics of different polymorphs CL-20 (α, γ and ε) has been investigated by thermogravimetry, IR spectroscopy optical electronic microscopy. reactions proceed with self-acceleration can be described a kinetic law first order autocatalysis. Already at the earliest stages (≤1%) phase transitions take place from αγ εγ. For this reason observed is related to γ-CL-20. On other hand, depends on initial polymorphic state, so that increases in series: α<γ<ε. Experiments...
We report on an extension of the quasi-resonance (QUASR) pulse sequence used for signal amplification by reversible exchange (SABRE), showing that we may target distantly J-coupled 19F-spins. Polarization transfer from parahydrogen-derived hydrides to 19F nucleus is accomplished via weak five-bond J-couplings using a shaped QUASR radio frequency at 0.05 T magnetic field. The net result direct generation hyperpolarized z-magnetization, derived parahydrogen singlet order. An accumulation...
13C-hyperpolarized carboxylates, such as pyruvate and acetate, are emerging molecular contrast agents for magnetic resonance imaging (MRI) visualization of various diseases, including cancer. Here, we present a systematic study 1H 13C parahydrogen-induced polarization acetate esters with ethyl, propyl, allyl alcoholic moieties. It was found that is the most efficiently hyperpolarized compound from those under study, yielding 21 5.4% nuclei, respectively, in CD3OD solutions. Allyl ethyl were...
Metronidazole and nimorazole are antibiotics of a nitroimidazole group originally designed for acting on anaerobic bacteria. These may be potentially utilized as hypoxia radiosensitizers the treatment cancerous tumors. Hyperpolarization 15N nuclei in these compounds using SABRE-SHEATH (Signal Amplification By Reversible Exchange SHield Enables Alignment Transfer to Heteronuclei) approach provides dramatic enhancement detection sensitivity analytes magnetic resonance spectroscopy imaging....