A5072707062- Advanced NMR Techniques and Applications
- Atomic and Subatomic Physics Research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Solid-state spectroscopy and crystallography
- Catalytic Processes in Materials Science
- Advanced MRI Techniques and Applications
- Catalysis and Oxidation Reactions
- Electron Spin Resonance Studies
- Hydrogen Storage and Materials
- NMR spectroscopy and applications
- Quantum, superfluid, helium dynamics
- Catalysts for Methane Reforming
- Zeolite Catalysis and Synthesis
- Metal complexes synthesis and properties
- Catalysis and Hydrodesulfurization Studies
- Magnetism in coordination complexes
- Mesoporous Materials and Catalysis
- Crystallography and molecular interactions
- Asymmetric Hydrogenation and Catalysis
- Inorganic Fluorides and Related Compounds
- Surface Chemistry and Catalysis
- Advanced Chemical Physics Studies
- Ammonia Synthesis and Nitrogen Reduction
- Metal-Organic Frameworks: Synthesis and Applications
Novosibirsk State University
2015-2025
Boreskov Institute of Catalysis
2016-2025
International Tomography Center
2020-2025
Siberian Branch of the Russian Academy of Sciences
2018-2021
Novosibirsk Tuberculosis Research Institute
2016
Russian Academy of Sciences
2012
Hyperpolarized
Abstract The hyperpolarization of heteronuclei via signal amplification by reversible exchange (SABRE) was investigated under conditions heterogeneous catalysis and microtesla magnetic fields. Immobilization [IrCl(COD)(IMes)], [IMes=1,3‐bis(2,4,6‐trimethylphenyl), imidazole‐2‐ylidene; COD=cyclooctadiene] catalyst onto silica particles modified with amine linkers engenders an effective SABRE (HET‐SABRE) that used to demonstrate a circa 100‐fold enhancement 15 N NMR signals in N‐pyridine at...
NMR hyperpolarization dramatically improves the detection sensitivity of magnetic resonance through increase in nuclear spin polarization. Because by several orders magnitude, additional applications have been unlocked, including imaging gases physiologically relevant conditions. Hyperpolarized
The successful transfer of parahydrogen-induced polarization to 15N spins using heterogeneous catalysts in aqueous solutions was demonstrated. Hydrogenation a synthesized unsaturated 15N-labeled precursor (neurine) with parahydrogen (p-H2) over Rh/TiO2 yielded hyperpolarized structural analog choline. As result, enhancements two orders magnitude were achieved for the 15N-ethyl trimethyl ammonium ion product deuterated water at elevated temperatures. Enhanced NMR spectra successfully acquired...
Signal Amplification By Reversible Exchange (SABRE) is a new and rapidly developing hyperpolarization technique. The recent discovery of Spin-Lock Induced Crossing SABRE (SLIC-SABRE) showed that high field transfer techniques developed so far were optimized for singlet spin order does not coincide with the experimentally produced state. Here, we investigated SLIC-SABRE approach most advanced quantitative theoretical model to date. Our goal achieve highest possible polarization at using...
A supported metal catalyst was designed, characterized, and tested for aqueous phase heterogeneous hydrogenation of vinyl acetate with parahydrogen to produce 13 C-hyperpolarized ethyl potential biomedical applications. The Rh/TiO2 a loading 23.2 wt % produced strongly hyperpolarized C-enriched acetate-1-13 C detected at 9.4 T. An approximately 14-fold signal enhancement using circa 50 gas without taking into account relaxation losses before after polarization transfer by magnetic field...
Iridium and rhodium complexes anchored on silica gel surface via NH 2 –(CH ) 3 – P(Ph) linker groups achieve high (∼9%) efficiency in pairwise addition of parahydrogen to unsaturated gaseous substrates heterogeneous hydrogenation processes.
Nuclear magnetic resonance is extremely attractive for operando studies of chemical reactors. However, the heterogeneous catalyst particles placed inside an NMR probe greatly affect uniformity field. This problem especially acute when studying hydrogenation processes using parahydrogen. Despite increased sensitivity due to hyperpolarization, under conditions a strong heterogeneity field, antiphase nature signals leads partial or even complete loss spectroscopic information significant signal...
Hyperpolarized (HP) MRI provides enhanced signals over conventional due to the increase in nuclear spin polarization by orders of magnitude compared thermal polarization. Therefore, HP can be successfully utilized toward imaging low-density gases void spaces, such as human lungs. Specifically, clinical pulmonary imaging, employs a gaseous contrast agent that fills lungs during inhalation under physiologically relevant conditions prior imaging. FDA-approved 129Xe gas now used first inhalable...
Hyperpolarized (HP) propane is a promising contrast agent for magnetic resonance imaging (MRI) of lungs and studying porous media. The parahydrogen-induced polarization (PHIP) technique convenient approach to produce pure gas with enhanced proton polarization, when hydrogenation propylene parahydrogen performed over heterogeneous catalysts. Here, we present new multidimensional mapping the efficiency pairwise addition using PHIP-echo pulse sequence. We use this study performance three model...
The feasibility of ultrafast (1.7 s) ventilation MRI with a 1 × 50 mm 3 voxel size is demonstrated using hyperpolarized propane gas contrast agent in excised rabbit lungs on 0.35 T clinical scanner without any modification.
Here, we report the production of <sup>13</sup>C-hyperpolarized ethyl acetate <italic>via</italic> heterogeneously catalyzed pairwise addition parahydrogen to vinyl over TiO<sub>2</sub>-supported rhodium nanoparticles, followed by magnetic field cycling.
We report a catalyst with the highest selectivity toward pairwise hydrogen addition of 7% among supported metal catalysts, found as result variation Rh/TiO<sub>2</sub> preparation procedures.
Methods based on magnetic resonance imaging (MRI) can be used for operando studies of heterogeneous catalytic processes in the gas phase. MRI provide a detailed understanding reactor operation information about spatial distribution reactants and reaction products. However, low spin density, fast diffusion, short relaxation times gases along with field inhomogeneities associated systems complicate such compromise achievable sensitivity. Spin hyperpolarization techniques general...
Hyperpolarized magnetic resonance imaging (MRI) contrast agents are revolutionizing the field of biomedical imaging. Xe-129 was recently FDA approved as an inhalable MRI agent for functional lung sensing. Despite success in research settings, modern hyperpolarizers expensive (up to $1M), large, and complex site operate. Moreover, sensing requires specialized hardware that is not commonly available on clinical scanners. Here, we demonstrate proton-hyperpolarized propane gas can be produced...
Abstract The hyperpolarization of heteronuclei via signal amplification by reversible exchange (SABRE) was investigated under conditions heterogeneous catalysis and microtesla magnetic fields. Immobilization [IrCl(COD)(IMes)], [IMes=1,3‐bis(2,4,6‐trimethylphenyl), imidazole‐2‐ylidene; COD=cyclooctadiene] catalyst onto silica particles modified with amine linkers engenders an effective SABRE (HET‐SABRE) that used to demonstrate a circa 100‐fold enhancement 15 N NMR signals in N‐pyridine at...
Abstract NMR hyperpolarization techniques have the potential to revolutionize field of spectroscopy and molecular MRI because they can transiently enhance nuclear spin polarization by 4–8 orders magnitude, with corresponding gains in signal‐to‐noise ratio (SNR). The SABRE‐SHEATH (Signal Amplification By Reversible Exchange SHield Enables Alignment Transfer Heteronuclei) technique, first demonstrated 2015, allows for direct, efficient (>20 % polarization), fast (in under one minute) 15 N...
Abstract Parahydrogen‐induced polarization (PHIP) was shown to be a useful and unique technique study the mechanisms of catalytic reactions involving hydrogen. In this paper, PHIP utilized for mechanistic investigation gas‐phase hydrogenation furan, 2,3‐dihydrofuran, 2,5‐dihydrofuran over titania‐supported Rh, Pd, Pt catalysts. all three substrates Rh/TiO 2 catalyst, revealed possibility pairwise addition two H atoms from same molecule with formation tetrahydrofuran molecules while retaining...
The growing interest in magnetic resonance imaging (MRI) for assessing regional lung function relies on the use of nuclear spin hyperpolarized gas as a contrast agent. long gas-phase lifetimes
Novel bimetallic Pd-Co catalysts supported on the carbon material Sibunit were synthesized by an incipient wetness impregnation method and used for ethylene production selective acetylene hydrogenation. It has been established that increase in Pd:Co molar ratio from 1:0 to 1:2 0.5%Pd-Co/C catalysts, treated hydrogen at 500 °C, leads selectivity 60 67% (T = 45 °C). The does not change with a further modifier concentration. investigated TPR-H2, XRD, TEM HR, EDS, XPS methods. was shown...