A5065338020- Advanced NMR Techniques and Applications
- Atomic and Subatomic Physics Research
- Advanced MRI Techniques and Applications
- Electron Spin Resonance Studies
- Solid-state spectroscopy and crystallography
- Nuclear Physics and Applications
- Quantum, superfluid, helium dynamics
- Chemical Reactions and Isotopes
- Radioactivity and Radon Measurements
- Estrogen and related hormone effects
- High-Energy Particle Collisions Research
- Nuclear physics research studies
- Radiopharmaceutical Chemistry and Applications
- Boron Compounds in Chemistry
- Metabolism and Genetic Disorders
- Bioactive Compounds and Antitumor Agents
- Diet and metabolism studies
- Particle physics theoretical and experimental studies
- Inorganic Fluorides and Related Compounds
- NMR spectroscopy and applications
- Cardiac Imaging and Diagnostics
- Radioactive contamination and transfer
- Chemical and Physical Properties in Aqueous Solutions
- Medical Imaging Techniques and Applications
The Barbara Ann Karmanos Cancer Institute
2019-2024
Wayne State University
2019-2024
University of Cambridge
2024
Millennium Institute for Integrative Biology
2020
University of Nottingham
2015-2017
The NMR hyperpolarization of uniformly
NMR hyperpolarization dramatically improves the detection sensitivity of magnetic resonance through increase in nuclear spin polarization. Because by several orders magnitude, additional applications have been unlocked, including imaging gases physiologically relevant conditions. Hyperpolarized
The presence of<sup>14</sup>N nucleus in the scalar coupling network results a 3-fold decrease of<sup>15</sup>N<italic>T</italic><sub>1</sub>and polarization values for all<sup>15</sup>N sites in<sup>15</sup>N<sub>2</sub>-metronidazole<italic>versus</italic><sup>15</sup>N<sub>3</sub>-metronidazole SABRE hyperpolarization microtesla fields.
Objectives The aim of the study was to translate abdominal deuterium metabolic imaging (DMI) clinical field strength by optimizing radiofrequency coil setup, administered dose ( 2 H)-labeled glucose, and data processing pipeline for quantitative characterization DMI signals over time. This assessed in kidney liver establish a basis routine studies future. Materials Methods 5 healthy volunteers were recruited imaged on or 3 separate occasions, with varying doses H-glucose: 0.75 g/kg (high...
The detection of hyperpolarized carbon-13 (HP 13C)-fumarate conversion to 13C-malate using 13C-MRSI is a biomarker for early cellular necrosis. Here, we describe the translation HP 13C-fumarate as novel human imaging agent, including evaluation biocompatibility and scaling up hyperpolarization methods clinical use. Preclinical biological validation was undertaken in fumarate hydratase-deficient murine tumor models controls. Safety assessed healthy rats (N = 18) volunteers 9). dissolution...
We present spin-exchange optical pumping (SEOP) using a third-generation (GEN-3) automated batch-mode clinical-scale 129Xe hyperpolarizer utilizing continuous high-power (∼170 W) pump laser irradiation and novel aluminum jacket design for rapid temperature ramping of xenon-rich gas mixtures (up to 2 atm partial pressure). The is capable heating SEOP cells from ambient (typically 25 °C) 70 °C (temperature the process) in 4 min, perform cooling cell at which hyperpolarized mixture can be...
Hyperpolarized magnetic resonance imaging (MRI) contrast agents are revolutionizing the field of biomedical imaging. Xe-129 was recently FDA approved as an inhalable MRI agent for functional lung sensing. Despite success in research settings, modern hyperpolarizers expensive (up to $1M), large, and complex site operate. Moreover, sensing requires specialized hardware that is not commonly available on clinical scanners. Here, we demonstrate proton-hyperpolarized propane gas can be produced...
We present an automated parahydrogen generator (ParaSun) for clinical-scale applications in parahydrogen-induced polarization (PHIP) and signal amplification by reversible exchange (SABRE) at high pressures. The device employs a vacuum-pumped, Sunpower cryo-cooler (typically employed cooling cellular network antennas) to achieve up ∼87% enrichment temperature as low ∼40 K maximum outlet pressure of ∼490 PSI. reaches the target set-point under 1 h. It FeO(OH) catalyst ortho- para-state...
We present a pilot quality assurance (QA) study of clinical-scale, automated, third-generation (GEN-3) 129Xe hyperpolarizer employing batch-mode spin-exchange optical pumping (SEOP) with high-Xe densities (50% natural abundance Xe and 50% N2 in ~2.6 atm total pressure sourced from Nova Gas Technologies) rapid temperature ramping enabled by an aluminum heating jacket surrounding the 0.5 L SEOP cell. hyperpolarization was performed over course 700 gas loading cycles cell, simulating long-term...
To assess the feasibility of sodium-23 MRI for performing quantitative and non-invasive measurements total sodium concentration (TSC) relaxation in a variety abdominal organs.
Low-field NMR has emerged as a new analytical technique for the investigation of molecular structure and dynamics. Here, we introduce highly integrated ultralow-frequency spectrometer designed purpose ultralow-field polarimetry hyperpolarized contrast media. The device measures 10 cm × 2.0 weighs only 370 g. spectrometer's aluminum enclosure contains all components, including an RF amplifier. four ports connecting to high-impedance transmit-receive coil, trigger input, USB port connectivity...
We present on the utility of in situ nuclear magnetic resonance (NMR) and near-infrared (NIR) spectroscopic techniques for automated advanced analysis 129Xe hyperpolarization process during spin-exchange optical pumping (SEOP). The developed software protocol, written MATLAB programming language, facilitates detailed characterization hyperpolarized contrast agent production efficiency based determination key performance indicators, including maximum achievable polarization, steady-state...
Abstract Hyperpolarization is a technique that can increase nuclear spin polarization with the corresponding gains in magnetic resonance (NMR) signals by 4–8 orders of magnitude. When this process applied to biologically relevant samples, hyperpolarized molecules be used as exogenous imaging (MRI) contrast agents. A called spin‐exchange optical pumping (SEOP) hyperpolarize noble gases such 129 Xe. Techniques based on Xe are poised revolutionize clinical lung imaging, offering non‐ionizing,...
Abstract Background Accurate non-invasive subtyping of localised kidney tumours is an unmet clinical question in uro-oncology. Differentiation benign renal oncocytomas (RO) from malignant chromophobe cell carcinomas (chRCC) not possible using conventional imaging. Despite the importance function for sodium regulation, little known about handling tumours. Purpose Here we used MRI ( 23 Na-MRI) to quantify concentration and relaxation dynamics across a range different tumour subtypes have...
Background The Warburg effect is a hallmark of cancer and characterized by increased glucose consumption lactate formation. Deuterium metabolic imaging (DMI) an emerging non-invasive MRI method for probing this reprogramming in the field neuroimaging. Here we show feasibility technique abdominal using routine 3 T system, which has previously presented significant technical challenges. Purpose This study aimed to translate DMI clinical strength optimizing radiofrequency coil setup,...
Motivation: Breast cancer MRI has high sensitivity but an unmet need for increased specificity. Sodium the potential to improve tumor characterisation and thus treatments. Goal(s): To determine whether there is a relationship between tissue permeability by correlating intracellular sodium fraction with pharmacokinetic parameters. Approach: Conventional DCE-MRI parameters were acquired as well maps (= inversion recovery / total concentration) in 17 breast lesions (grade 1:n=3; grade 2: n=9;...
Motivation: Abdominal imaging of orally-administered deuterium-labelled tracers can be hindered by artifacts arising from excessive stomach signal. Goal(s): To establish and optimize methods for acquisition abdominal deuterium metabolic in conjunction with tracers. Approach: A flexible transmit-receive surface coil was used to image naturally abundant healthy volunteers D2O a patient renal cancer. Results: Water lipid peaks were repeatably fit high confidence both unlocalised spectra voxels...
Motivation: Clinical translation of hyperpolarized 13C-fumarate has the potential to enable early, non-invasive assessment treatment response in cancer. Goal(s): To advance a novel probe from laboratory clinic. Approach: Translation involved optimizing clinical scale hyperpolarization, establishing an imaging protocol at field strength (3T), preclinical toxicology and first in-human injections. Results: showed good hyperpolarization properties achieved sufficient spectral separation peaks...
Motivation: Sodium homeostasis is altered in abdominal pathologies such as cancer and cardiovascular disease, but established quantification techniques require an invasive biopsy. Goal(s): Quantification of sodium content T2* relaxation organs fluid-filled structures using 23Na-MRI. Approach: Proton imaging the abdomen was performed 18 healthy volunteers a 3D cones sequence sodium-tuned body coil on clinical 3 T system. Results: Mean total concentration long times were measured 8 structures;...