A5069072642- Advanced NMR Techniques and Applications
- Atomic and Subatomic Physics Research
- Advanced MRI Techniques and Applications
- Solid-state spectroscopy and crystallography
- NMR spectroscopy and applications
- Electron Spin Resonance Studies
- Quantum optics and atomic interactions
- Quantum, superfluid, helium dynamics
- Spectroscopy Techniques in Biomedical and Chemical Research
- Optical Imaging and Spectroscopy Techniques
- Inorganic Fluorides and Related Compounds
- Spectroscopy and Quantum Chemical Studies
- Enzyme Structure and Function
- High-pressure geophysics and materials
- Nonlinear Optical Materials Research
- Diamond and Carbon-based Materials Research
- Soybean genetics and cultivation
- Ammonia Synthesis and Nitrogen Reduction
- Laser-Matter Interactions and Applications
- Acoustic Wave Resonator Technologies
- Molecular spectroscopy and chirality
- Mass Spectrometry Techniques and Applications
- bioluminescence and chemiluminescence research
- Functional Brain Connectivity Studies
- Mechanical and Optical Resonators
Karlsruhe Institute of Technology
2022-2025
Kerntechnische Entsorgung Karlsruhe (Germany)
2025
North Carolina State University
2020-2023
RWTH Aachen University
2015-2019
Molecular metabolic imaging in humans is dominated by positron emission tomography (PET). An emerging nonionizing alternative hyperpolarized MRI of 13C-pyruvate, which innocuous and has a central role metabolism. However, similar to PET, with dissolution dynamic nuclear polarization (d-DNP) complex costly, requires significant infrastructure. In contrast, Signal Amplification By Reversible Exchange (SABRE) fast, cheap, scalable hyperpolarization technique. SABRE SHield Enables Alignment...
Optically-probed nitrogen-vacancy (NV) quantum defects in diamond can detect nuclear magnetic resonance (NMR) signals with high-spectral resolution from micron-scale sample volumes of about 10 picoliters. However, a key challenge for NV-NMR is detecting samples at millimolar concentrations. Here, we demonstrate an improvement proton concentration sensitivity $10^5$ over thermal polarization by hyperpolarizing spins through signal amplification reversible exchange (SABRE), enabling NMR small...
The spatial resolution of magnetic resonance imaging (MRI) is limited by the width Lorentzian point spread functions associated with transverse relaxation rate 1/ T 2 * . Here, we show a different contrast mechanism in MRI establishing RASER (radio-frequency amplification stimulated emission radiation) imaged media. bursts emerge out noise and without applying radio-frequency pulses when placing spins sufficient population inversion weak field gradient. Small local differences initial...
We introduce a Spin Transfer Automated Reactor (STAR) that produces continuous parahydrogen induced polarization (PHIP), which is stable for hours to days. use the PHIP variant called signal amplification by reversible exchange (SABRE), particularly well suited produce hyperpolarization. The STAR operated in conjunction with benchtop (1.1 T) and high field (9.4 NMR magnets, highlighting versatility of this system operate any or MRI system. uses semipermeable membranes efficiently deliver...
13C hyperpolarized pyruvate is an emerging MRI contrast agent for sensing molecular events in cancer and other diseases with aberrant metabolic pathways. This can be produced via several hyperpolarization techniques. Despite remarkable success research settings, widespread clinical adoption faces substantial roadblocks because the current technology utilized to sense this requires excitation of nuclear spins that also need synchronized field gradient pulses. Here, we demonstrate allyl...
Precision in nuclear magnetic resonance (NMR) spectroscopy and resolution imaging (MRI) are thought to be fundamentally limited by the transverse relaxation time. With recent advent of radiofrequency amplification stimulated emission radiation (RASER), it is becoming apparent that RASERs can break these fundamental limitations provide significant improvements NMR spectra MRI images. In this article, we show carbon-13 controlled changes field homogeneity spin coupling network. As illustrative...
Abstract Radio amplification by stimulated emission of radiation (RASER) was recently discovered in a low‐field NMR spectrometer incorporating highly specialized radio‐frequency resonator, where high degree proton‐spin polarization achieved reversible parahydrogen exchange. RASER activity, which results from the coherent coupling between nuclear spins and inductive detector, can overcome limits frequency resolution NMR. Here we show that this phenomenon is not limited to low magnetic fields...
Parahydrogen (p-H2)-based techniques are known to drastically enhance NMR signals but usually limited by p-H2 supply. This work reports p-H2-based SABRE hyperpolarization at pressures of hundreds bar, far beyond the typical ten bar currently reported in literature. A recently designed high-pressure setup was utilized compress gas up 200 bar. The measurements were conducted using a sapphire tube and 43 MHz benchtop spectrometer. In standard methanol solutions, it could be shown that signal...
Abstract A RASER (Radio Amplification by Stimulated Emission of Radiation) facilitates the study nonlinear phenomena, as well determination NMR parameters with high precision. To achieve maximum sensitivity in desired operating mode, it is crucial to control over long periods time. So far, this was only possible at ultra‐low magnetic fields. Here, we introduce a way regime field 1.45 T. We employ continuous‐flow RASER, pumped PHIP (ParaHydrogen Induced Polarization). The hydrogenation vinyl...
Abstract The feasibility of Carbon‐13 Radiofrequency (RF) Amplification by Stimulated Emission Radiation (C‐13 RASER) is demonstrated on a bolus liquid hyperpolarized ethyl [1‐ 13 C]acetate. Hyperpolarized C]acetate was prepared via pairwise addition parahydrogen to vinyl and polarization transfer from nascent parahydrogen‐derived protons the carbon‐13 nucleus magnetic field cycling yielding C‐13 nuclear spin approximately 6 %. RASER signals were detected samples with concentration ranging...
Conventional nuclear magnetic resonance (NMR) enables detection of chemicals and their transformations by exciting spin ensembles with a radio-frequency pulse followed the precessing spins at characteristic frequencies. The detected frequencies report on chemical reactions in real time signal amplitudes scale concentrations products reactants. Here, we employ Radiofrequency Amplification Stimulated Emission Radiation (RASER), quantum phenomenon producing coherent emission 13C signals, to...
High-field nuclear magnetic resonance (NMR) spectroscopy is an indispensable technique for identification and characterization of chemicals biomolecular structures. In the vast majority NMR experiments, spin polarization arises from thermalization in multi-Tesla fields produced by superconducting magnets. contrast, instruments operating at low are emerging as a compact, inexpensive, highly accessible alternative but suffer thermal field strength consequently signal. However, certain...
Abstract Radio amplification by stimulated emission of radiation (RASER) was recently discovered in a low‐field NMR spectrometer incorporating highly specialized radio‐frequency resonator, where high degree proton‐spin polarization achieved reversible parahydrogen exchange. RASER activity, which results from the coherent coupling between nuclear spins and inductive detector, can overcome limits frequency resolution NMR. Here we show that this phenomenon is not limited to low magnetic fields...
Abstract Radio-frequency Amplification by Stimulated Emission of Radiation (RASER) is a promising tool to study nonlinear phenomena or measure NMR parameters with unprecedented precision. Magnetic fields, J -couplings, and chemical shifts can be recorded over long periods time without the need for radiofrequency excitation signal averaging. One key feature RASER spectroscopy improvement in precision, which grows measurement $$T_{{\text{m}}}^{3/2}$$ <mml:math...
Signal amplification by reversible exchange (SABRE) is a robust and inexpensive hyperpolarization (HP) technique to enhance nuclear magnetic resonance (NMR) spectroscopy imaging (MRI) signals using parahydrogen (pH2 ). The substrate scope of SABRE continually expanding. Here, we present the polarization three antifungal drugs (voriconazole, clotrimazole, fluconazole) elicit detailed HP mechanisms for 1 H 15 N nuclei. In this exploratory work, values ~1% were achieved 50% pH2 in solution 3-mM...
Hyperpolarization modalities overcome the sensitivity limitations of NMR and unlock new applications. Signal amplification by reversible exchange (SABRE) is a particularly cheap, quick, robust hyperpolarization modality. Here, we employ SABRE for simultaneous chemical parahydrogen nitrile-containing anticancer drugs (letrozole or anastrozole) to enhance