A5010553971- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Advanced MRI Techniques and Applications
- Particle Detector Development and Performance
- Analog and Mixed-Signal Circuit Design
- CCD and CMOS Imaging Sensors
- Atomic and Subatomic Physics Research
- Advanced X-ray and CT Imaging
- Particle physics theoretical and experimental studies
- Astrophysics and Cosmic Phenomena
- Radiomics and Machine Learning in Medical Imaging
- Neutrino Physics Research
- Cardiac Imaging and Diagnostics
- High-Energy Particle Collisions Research
- Radiopharmaceutical Chemistry and Applications
- Nuclear Physics and Applications
- Advanced Radiotherapy Techniques
- Advancements in PLL and VCO Technologies
- Photonic and Optical Devices
- Neuroscience and Neural Engineering
- Semiconductor materials and devices
- Lanthanide and Transition Metal Complexes
- Dental Implant Techniques and Outcomes
- Particle Accelerators and Free-Electron Lasers
- dental development and anomalies
Bharati Vidyapeeth Deemed University
2024
Brookhaven National Laboratory
2004-2020
Brookhaven College
2012
Stony Brook University
2006-2009
We developed a non-magnetic positron-emission tomography (PET) device based on the rat conscious animal PET that operates in small-animal magnetic resonance imaging (MRI) scanner, thereby enabling us to carry out simultaneous PET/MRI studies. The detector comprises 12 blocks, each being 4 × 8 array of lutetium oxyorthosilicate crystals (2.22 2.22 5 mm(3)) coupled matching avalanche photodiode array. housed plastic case, form 38 mm inner diameter ring with an 18 axial extent. Custom-built MRI...
Anesthesia is currently required for positron emission tomography (PET) studies of the animal brain in order to eliminate motion artifacts. However, anesthesia profoundly affects neurological state animal, complicating interpretation PET data. Furthermore, it precludes use study during normal behavior. The rat conscious tomograph (RatCAP) designed need studies. It a miniaturized full-ring scanner that attached directly head, imaging nearly entire brain. RatCAP utilizes arrays 2 mm /spl...
<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> The RatCAP has been designed and constructed to image the awake rat brain. In order maximize system performance, offline digital coincidence data processing algorithms including offset delay correction prompt delayed detection have developed validated. With using a singular value decomposition (SVD) technique, overall time resolution was improved from 32.6 17.6 ns FWHM. experimental results...
At Brookhaven National Laboratory, we are developing a simultaneous PET-MRI breast imaging system. A prototype II version of the PET system has been constructed. This device consists 24 detector blocks where each block 4 × 8 array 2.2 15 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> LYSO crystal directly coupled to non-magnetic APD array. The scanner an inner diameter 100 and axial extent 18 mm. Resolution measurements were carried...
We report on the development of front-end electronics for rat conscious animal positron emission tomography (RatCAP), a portable and miniature scanner. The application-specific integrated circuit (ASIC) is realized in complementary metal-oxide-semiconductor 0.18 /spl mu/m technology composed 32 channels charge sensitive preamplifier, third-order semi-Gaussian bipolar shaper, timing discriminator with independent channel adjustable threshold, 32-line address serial encoder to minimize number...
The ability to acquire high resolution anatomical data as well quantitative functional information in vivo is becoming an increasingly important factor the diagnosis of disease. Simultaneous acquisition PET and MRI would provide essentially perfect co-registration between two images which particularly for tissues whose position shape can change sequential scans. RatCAP a complete 3D tomograph that designed image brain awake rat. A special coil composed 2 saddle elements working quadrature...
We present FPGA-based self calibrating Time to Digital Converter (TDC) architecture specific applications where one is interested in measuring absolute time of occurrence an event since t <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</inf> by combining coarse (simple binary counter at system clock speed) and fine TDC. The relies on accurate crystal oscillator provide stable reference generate calibration test pulse. It uses two controllable...
We report on the design and characterization of a new ASIC for RatCAP, head-mounted miniature PET scanner intended neurological behavioral studies an awake rat. The is composed 32 channels, each consisting charge sensitive preamplifier, 5-bit programmable gain in pole-zero network, 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> order bipolar semi-Gaussian shaper (peaking time 80 ns), timing energy discriminator. discriminator channel...
We describe the architecture of a FPGA-based self-calibrating Time to Digital Converter (TDC), specifically intended measure width an input pulse. The configuration consists two controllable ring oscillators with very small difference in their frequencies, wherein this determines achievable resolution. calibration scheme relies on accurate pulse-generator or external crystal-oscillator provide stable pulse for system. implemented TDC Altera Stratix II device where we measured Least...
Front end digital signal processing and VME based DAQ electronics for the RatCAP (Rat Conscious Animal PET) is discussed. All approach to front mobile animal PET scanner presented. Altera Cyclone family FPGA realization of 12 channel TDC (time converter), address serial decoder system development discussed in detail. Routing delays between logic array blocks combined with propagation delay cells were used generate different clock phases, achieve subclock speed resolution. LogicLock/spl...
RatCAP (Rat Conscious Animal PET) is miniature positron emission tomography scanner intended for neurological and behavioral study of small awake animal. The system comprises three distinct modules: rigid-flex technology based Printed Circuit Board (PCB) which houses the detector components front end Application Specific Integrated (ASIC), Time to Digital Converter Signal Processing module (TSPM) receives processes ASIC signals transmits processed data over two Giga bit fiber optic links PCI...
Aim : We aim to assess and contrast the mechanical stability of two mini-implant designs, featuring larger diameters shorter lengths, for orthodontic anchorage against a conventional group implants. Materials methods Three groups underwent testing: implants in Group 1 were 2.5 mm diameter 4 length; 2 3 1.3 7 length. Both types Abso Anchor mini-implants (Dentos Inc.). The implants’ was assessed using maximum insertion torque (MIT), removal (MRT), angulated lateral displacement tests...
We propose to develop a high resolution scanner for simultaneous PET and MRI breast imaging that is capable of providing highly sensitive specific cancer examinations. The addition positron emission tomography capability an existing dedicated system will give device in which each the modalities contributes its strengths compensate weaknesses other. In this combined modality scanner, we have anatomical information from somewhat poorer PET, predictive power identifying type lesion overcome...
The original prototype RatCAP PET scanner for conscious rat brain imaging has undergone a redesign of most major components resulting in distinct 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> -generation instrument. While maintaining the same field view (38 mm diameter, 18 axial) and similar overall architecture, new design allows longer crystals to provide approximately factor increase coincidence sensitivity with minimal size...
We are developing a scanner that will allow the simultaneous acquisition of high resolution anatomical data using Magnetic Resonance Imaging (MRI) and quantitative physiological Positron Emission Tomography (PET). The approach is based on technology used for RatCAP conscious small animal PET tomograph which utilizes block detectors consisting pixelated arrays LSO crystals read out with matching avalanche photodiodes (APDs) custom-designed ASIC. A version detector being developed be...
Kinetic modeling permits quantification of radiotracer dynamics in tissue by using the amount radioactivity blood as an input function to a kinetic model. This usually requires obtaining multiple samples during dynamic PET scans. As this procedure is considered health risk for patient and medical personnel, wrist scanner has been devised that can be used obtain with minimum discomfort without drawing arterial blood. A prototype two detector pairs evaluated. The spatial resolution,...
The first fully functional prototype of the RatCAP (Rat conscious animal PET) scanner has been constructed and preliminary evaluations have performed. is a miniature, high performance PET designed specifically to image brain rat while directly attached its head. goal eliminate need for anesthesia which can confound quantitative studies prevent simultaneous correlations neurochemistry behavior. 3D tomograph with transaxial (axial) field-of-view 38(18) mm, outside diameter 72 weight <200 g...
The feasibility of performing high-resolution PET and high-field MRI simultaneously in rodents has been previously demonstrated small-scale systems capable imaging the rat brain mouse. We are nearing completion a larger scale system which will accommodate whole perform at 9.4 T with <;2 mm resolution. insert inner/outer diameters 13.5/20.6 cm, compact enough to fit within gradient set Varian large-bore 9.4T while accommodating on inside commercial Insight birdcage coil for rat. resulting...
Combining PET and MRI technology in order to obtain simultaneous functional information with anatomical precision vivo is of tremendous interest the field molecular imaging. PET/MRI imaging provides perfect temporal coregistration MR images, along clear delineation tissue boundaries. An compatible scanner based on Rat Conscious Animal (RatCAP) developed for acquisition images rat brain a 9.4 T microMRI scanner. The tomograph housed segmented G10/copper case constructed copper coating...
The Muon Spectrometer of the ATLAS detector at LHC is designed to provide high quality stand-alone muon identification, momentum measurement and trigger capabilities with pseudorapidity coverage. Precision tracking inner-most station in regions, 2.0 ≪ |η| 2:7, performed by 16 four-layered Cathode Strip Chambers on each end-cap. These are multi-wire proportional chambers segmented cathodes providing excellent spatial resolution counting rate capability. second cathode layer coarsely...
In order to assess the kinetics of radiotracer accumulation in tissue, amount radioactivity blood must be quantitatively measured as an input function kinetic model. Due safety and comfort issues with invasive determination function, a non-invasive method for arterial measurement is investigated using wrist scanner. A prototype consisting two detector pairs LSO APD arrays used obtain planar images anatomically correct phantom. The spatial resolution sensitivity determined. results showed was...