A5075307321- Biomedical Ethics and Regulation
- Ethics in Clinical Research
- Pluripotent Stem Cells Research
- Ethics in medical practice
- Science, Research, and Medicine
- Health Systems, Economic Evaluations, Quality of Life
- Biomedical and Engineering Education
- Advanced Radiotherapy Techniques
- Academic integrity and plagiarism
- Health and Medical Research Impacts
- Pharmaceutical industry and healthcare
- Neuroethics, Human Enhancement, Biomedical Innovations
- CRISPR and Genetic Engineering
- Reproductive Health and Technologies
- Angiogenesis and VEGF in Cancer
- Ethics and Legal Issues in Pediatric Healthcare
- Radiation Therapy and Dosimetry
- Misinformation and Its Impacts
- Organ and Tissue Transplantation Research
- scientometrics and bibliometrics research
- Patient Dignity and Privacy
- Artificial Intelligence in Healthcare and Education
- Radiation Effects and Dosimetry
- Academic Publishing and Open Access
- Global Health and Surgery
Wake Forest University
2024-2025
Forest Institute
2024-2025
National Cancer Centre Singapore
2020-2024
Rice University
2022-2024
Mayo Clinic
2017-2023
Mayo Clinic in Arizona
2019-2023
Mayo Clinic in Florida
2017-2023
WinnMed
2018-2022
GTx (United States)
2020
Albany Medical Center Hospital
2013-2018
Although standard anticancer chemotherapeutic drugs have been designed to inhibit the survival or growth of rapidly dividing tumor cells, it is possible enhance efficacy such by targeting proliferating host endothelial cells (ECs) vasculature. A theoretical advantage this strategy lies in possibility circumventing, significantly delaying, acquired drug resistance driven genetic instability cells. Here, we show that both vascular factor (VEGF) and basic fibroblast reduce pro-apoptotic potency...
The Tek/Tie2 receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development. To study the signal transduction pathways that are mediated by this receptor, we have used yeast two-hybrid system to identify signaling molecules associate with phosphorylated Tek receptor. Using approach, demonstrate five molecules, Grb2, Grb7, Grb14, Shp2, p85 subunit of phosphatidylinositol 3-kinase can interact phosphotyrosine-dependent manner through their SH2 domains. Mapping binding...
Over the past two decades, promotion of collaborative partnerships involving researchers from low and middle income countries with those high has been a major development in global health research. Ideally, these would lead to more equitable collaboration including sharing research responsibilities rewards. While partnership initiatives have shown promise attracted growing interest, there little scholarly debate regarding fair distribution authorship credit within partnerships.
Numerous social, economic and academic pressures can have a negative impact on representations of biomedical research. We review several the forces playing an increasingly pernicious role in how health science information is interpreted, shared used, drawing discussions towards narrative. In turn, we explore aspects narrative are used different social contexts communication environments, present creative responses that may help counter trends. As traditional methods many ways failed public,...
Misunderstanding and disputes about authorship are commonplace among members of multi/interdisciplinary health research teams. If left unmanaged unresolved, these conflicts can undermine knowledge sharing collaboration, obscure accountability for research, contribute to the incorrect attribution credit. To mitigate issues, certain researchers suggest quantitative distributions schemes (e.g., point systems), while others wish replace or minimize importance by using "contributorship"-a system...
Providers capitalize on patient testimonials to market unproven stem cell treatments (SCTs). We evaluated 159 YouTube videos and found patients discussed health improvements (91.2%), praised providers (53.5%), recommended SCTs (28.9%). In over a third of the videos, posed questions patients, thereby directing narratives making them powerful marketing tool.
We conducted a cross-sectional survey of 1,540 researchers concerning their experiences with and attitudes toward the ethics equal contribution (EC) designations in publications. Over half respondents (58.3%) said they had been designated as an EC at least once. Although most agreed that can be useful way promoting collaborations (81.7%) or resolving disagreements about authorship order (63.3%), substantial proportion (38.1%) regarded these but ethically questionable. 31.7% are questionable...
Tie2/Tek is an endothelial cell receptor tyrosine kinase that induces signal transduction pathways involved in migration upon angiopoietin-1 (Ang1) stimulation. To address the importance of various residues Tie2 transduction, we generated a series mutants and examined their signaling properties. Using this approach conjunction with phosphorylation state-specific antibody, identified residue 1106 on as Ang1-dependent autophosphorylation site mediates binding downstream-of-kinase-related...