A5089905976- Angiogenesis and VEGF in Cancer
- Vascular Malformations and Hemangiomas
- Allergic Rhinitis and Sensitization
- Dermatological and COVID-19 studies
- Contact Dermatitis and Allergies
- Chronic Myeloid Leukemia Treatments
- Parvovirus B19 Infection Studies
- Nonmelanoma Skin Cancer Studies
- Cell death mechanisms and regulation
- Streptococcal Infections and Treatments
- Oral Health Pathology and Treatment
- Cancer, Hypoxia, and Metabolism
- Food Allergy and Anaphylaxis Research
- Cancer Treatment and Pharmacology
- Digital Imaging in Medicine
- Marketing and Advertising Strategies
- Vascular Malformations Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Lipid metabolism and disorders
- Neuropeptides and Animal Physiology
- Hippo pathway signaling and YAP/TAZ
- HIV/AIDS Research and Interventions
- Reconstructive Facial Surgery Techniques
- Infection Control and Ventilation
- Migration, Health and Trauma
University of Wisconsin–Madison
2019-2024
University of Toronto
2001-2016
National Institute of Diabetes and Digestive and Kidney Diseases
2014
Thomas Jefferson University
2012
Florida State University
2010
Sunnybrook Health Science Centre
1999-2005
Health Sciences Centre
1999-2003
McMaster University
2002
Although standard anticancer chemotherapeutic drugs have been designed to inhibit the survival or growth of rapidly dividing tumor cells, it is possible enhance efficacy such by targeting proliferating host endothelial cells (ECs) vasculature. A theoretical advantage this strategy lies in possibility circumventing, significantly delaying, acquired drug resistance driven genetic instability cells. Here, we show that both vascular factor (VEGF) and basic fibroblast reduce pro-apoptotic potency...
Activation of the GPCR sphingosine-1-phosphate receptor 1 (S1P1) by (S1P) regulates key physiological processes. S1P1 activation also has been implicated in pathologic processes, including autoimmunity and inflammation; however, vivo sites under normal disease conditions are unclear. Here, we describe development a mouse model that allows evaluation activation. These mice, known as GFP signaling produce fusion protein containing transcription factor linked protease cleavage site at C...
Tie2/Tek is an endothelial cell receptor tyrosine kinase that induces signal transduction pathways involved in migration upon angiopoietin-1 (Ang1) stimulation. To address the importance of various residues Tie2 transduction, we generated a series mutants and examined their signaling properties. Using this approach conjunction with phosphorylation state-specific antibody, identified residue 1106 on as Ang1-dependent autophosphorylation site mediates binding downstream-of-kinase-related...
Corticosteroid insensitivity (CSI) represents a profound challenge in managing patients with asthma. We recently demonstrated that short exposure of airway smooth muscle cells (ASMCs) to proasthmatic cytokines drastically reduced their responsiveness glucocorticoids (GCs), an effect was partially mediated via interferon regulatory factor-1, suggesting the involvement additional mechanisms (Am J Respir Cell Mol Biol 2008;38:463-472). Although GC receptor (GR) can be phosphorylated at multiple...
Abstract Mosaic KRAS variants and other RASopathy genes cause oculoectodermal, encephalo‐cranio‐cutaneous lipomatosis, Schimmelpenning‐Feuerstein‐Mims syndromes, a spectrum of vascular malformations, overgrowth associated anomalies, the latter which are only recently being characterized. We describe eight individuals in total (six unreported cases two previously reported cases) with somatic variably features. Given findings (in seven individuals) or lymphatic malformations individuals), we...
<h3>Importance</h3> Keratinocyte carcinoma (nonmelanoma skin cancer) accounts for substantial burden in terms of high incidence and health care costs but is excluded by most cancer registries North America. Administrative insurance claims databases offer an opportunity to identify these cancers using diagnosis procedural codes submitted reimbursement purposes. <h3>Objective</h3> To apply recursive partitioning derive validate a claims-based algorithm identifying keratinocyte with sensitivity...
Elevated pernio incidence was observed during the COVID-19 pandemic. This prospective study enrolled subjects with pandemic-associated in Wisconsin and Switzerland. Because is a cutaneous manifestation of interferonopathies, type I interferon (IFN-I) immunity critical to recovery, we tested hypothesis that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-mediated IFN-I signaling might underlie some cases. Tissue-level activity plasmacytoid dendritic cell infiltrates were...
Dok-R, also known as Dok-2/FRIP, belongs to the DOK family of signaling molecules that become tyrosinephosphorylated by several different receptor and cytoplasmic tyrosine kinases. Tyrosine phosphorylation proteins establishes high affinity binding sites for other leading activation a cascade. Here we show Dok-R associates with c-Abl directly via constitutive SH3-mediated interaction this requires PMMP motif in proline-rich tail Dok-R. The Dok-R-Abl is further enhanced an active kinase,...
Consumers seek "clean" and "natural" products based on their perception of safety. However, there is no standard, scientific basis, or regulatory oversight in the marketing ingredient use for products.The aim this study was to determine prevalence allergenic ingredients products.Target Walgreens Web sites were queried with inclusion 1470 products. Ingredient lists analyzed potential allergens. Analysis included descriptive statistics χ2 test.The most common allergens fragrances/botanicals...
Abstract Background and Objectives Cutaneous capillary malformations (CMs) describe a group of vascular birthmarks with heterogeneous presentations. CMs may present as an isolated finding or other associations, including glaucoma leptomeningeal angiomatosis (i.e., Sturge–Weber syndrome) pigmentary phakomatosis pigmentovascularis). The use targeted genetic sequencing has revealed that postzygotic somatic variations in GNAQ GNA11 at codon 183 are associated CMs. We report five patients...
This study investigates how shopping centres communicate their market position to perspective shoppers. The content analysis of lifestyle centre communications is framed in Fishbein's multi-attribute model. purpose this investigate if websites clearly the identified retail attributes customers. Nine related retailing, previous research, were used create a model that provided basis for study. Fifty recently established life-style websites, by International Council Shopping Centers (ICSC)...
HIV testing is mandatory for individuals wishing to immigrate Canada. Since the Designated Medical Practitioners (DMPs) who perform these tests may have varying experience in and time constraints their clinical practices, there be variability quality of pre- posttest counseling provided. We surveyed DMPs regarding testing, counseling, immigration inadmissibility. A 16-item survey was mailed all across Canada (N = 203). The inquired about DMP characteristics, knowledge HIV, attitudes...