A5038317135- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Particle Detector Development and Performance
- Advanced X-ray and CT Imaging
- Atomic and Subatomic Physics Research
- CCD and CMOS Imaging Sensors
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Nuclear Physics and Applications
- Advanced Optical Sensing Technologies
- Analog and Mixed-Signal Circuit Design
- Neuroscience and Neural Engineering
- Radiation Dose and Imaging
- Treatment of Major Depression
- Advanced MRI Techniques and Applications
- Advancements in PLL and VCO Technologies
- Optical Imaging and Spectroscopy Techniques
- Attention Deficit Hyperactivity Disorder
- Schizophrenia research and treatment
- Advanced Memory and Neural Computing
- Epilepsy research and treatment
- Dark Matter and Cosmic Phenomena
- Child and Adolescent Psychosocial and Emotional Development
- Photoacoustic and Ultrasonic Imaging
- Advanced Radiotherapy Techniques
- Neutrino Physics Research
Université de Sherbrooke
2016-2025
McGill University
1982-2020
TRIUMF
2020
Australian College of Optometry
2020
The University of Melbourne
2020
RMIT University
2020
University of Massachusetts Amherst
2019
Centre Hospitalier Universitaire de Sherbrooke
2016-2017
University of Amsterdam
2009
Institute of Electrical and Electronics Engineers
2007
In this double-blind, placebo-controlled study of 4 weeks benzodiazepine treatment followed by 3 abrupt or gradual drug withdrawal, 16 patients whose was withdrawn abruptly were worse (p less than .05) 13 who had received placebo in terms change mean anxiety scores from the pretreatment level. The seven (44%) increased 10% more on both Hamilton Rating Scale for Anxiety and Self Symptom Scale. There no cases rebound 14 gradually; fewer seen with a that long half-life.
The LabPETtrade is a fully digital avalanche photodiode (APD) based PET scanner designed for state-of-the-art molecular and genomic imaging of small animals. Two versions the were evaluated, having 3.75 (LabPET4) 7.5 cm axial FOV (LabPET8). detectors are made 2times2times12/14 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> LYSO LGSO crystals assembled in phoswich pairs read out by an APD. After crystal identification, average energy...
The next-generation Enriched Xenon Observatory (nEXO) is a proposed experiment to search for neutrinoless double beta ($0\nu\beta\beta$) decay in $^{136}$Xe with target half-life sensitivity of approximately $10^{28}$ years using $5\times10^3$ kg isotopically enriched liquid-xenon time projection chamber. This improvement two orders magnitude over current limits obtained by significant increase the mass, monolithic and homogeneous configuration active medium, multi-parameter measurements...
The highly multiplexed analog processing front-end of current Positron Emission Tomography (PET) scanners yields high accuracy for timing but adds significant dead time and offers little flexibility improvement. A new fully digital APD-based scanner architecture is proposed wherein nuclear pulses are sampled directly at the output Charge Sensitive Preamplifier (CSP) with one free-running ADC per channel. This approach opportunity to explore signal algorithms borrowed from other fields like...
Anesthesia is currently required for positron emission tomography (PET) studies of the animal brain in order to eliminate motion artifacts. However, anesthesia profoundly affects neurological state animal, complicating interpretation PET data. Furthermore, it precludes use study during normal behavior. The rat conscious tomograph (RatCAP) designed need studies. It a miniaturized full-ring scanner that attached directly head, imaging nearly entire brain. RatCAP utilizes arrays 2 mm /spl...
Valproic acid (VA), an anticonvulsant which increases GABAergic transmission was given to patients suffering from recurrent panic attacks. Ten consecutive outpatients were included in this study. After a seven day placebo washout period, dose of 500 mg/day, gradually increased maximum 2250 mg/day. A significant improvement found the symptomatology as measured on Clinical Global Impression Scale for severity (p < 0.001), Hamilton Psychiatric Rating Anxiety 0.001) and factor SCL-90 0.05)....
In a 9-week open label study, seven outpatients with obsessive-compulsive disorder were treated fluoxetine, selective inhibitor of neuronal reuptake serotonin. After 7-day placebo washout period, patients given dose 40 mg/day, which was gradually increased to maximum 80 mg/day. A significant improvement found in the symptomatology as measured on subscale Comprehensive Psychopathological Rating Scale (p < 0.001) and Clinical Global Impression severity illness 0.01). These findings support...
This paper presents a new quenching circuit (QC) and single photon avalanche diode (SPAD) implemented in TSMC CMOS 65 nm technology. The QC was optimized for timing resolution (SPTR) with view to an implementation 3D digital SiPM. presented has jitter of 4 ps full width at half maximum (FWHM) the SPAD 7.8 FWHM SPTR. adjustable threshold allows optimization as well excess voltage rise time characterization. threshold, hold-off recharge are essential optimize performances each SPAD. also...
The LabPET is an avalanche photodiode (APD) based digital PET scanner with quasi-individual detector read-out and highly parallel electronic architecture for high-performance in vivo molecular imaging of small animals. on LYSO LGSO scintillation crystals (2×2×12/14 mm3), assembled side-by-side phoswich pairs read out by APD. High spatial resolution achieved through the individual independent APD recording impinging annihilation photons. exists three versions, LabPET4 (3.75 cm axial length),...
Abstract Objective. Integrating time-of-flight (ToF) measurements in radiography and computed tomography (CT) enables an approach for scatter rejection imaging systems that eliminates the need anti-scatter grids, potentially increasing system sensitivity image quality. However, present hardware dedicated to time-correlated measurement of X-rays is limited a small scale low density. A switch highly integrated electronics detectors needed progress towards medium-scale capable acquiring images,...
Skin cooling results in the activation of heat generating mechanisms to counteract lost environment. Here, we aim understand extent that variations cold-stimulated production may be driven by differences contribution shivering and non-shivering thermogenesis (NST) interaction with biological sex. Using a novel mean skin temperature clamping technique healthy men women, our data shows rises increasing myocardial oxidative metabolism temperature-dependent fashion. Shivering were also...
Abstract The challenge to reach 10 ps coincidence time resolution (CTR) in time-of-flight positron emission tomography (TOF-PET) is triggering major efforts worldwide, but timing improvements of scintillation detectors will remain elusive without depth-of-interaction (DOI) correction long crystals. Nonetheless, this momentum opportunely brings up the prospect a fully time-based DOI estimation since fast signals intrinsically carry information, even with traditional single-ended readout....
Retinal implants aim to partially restore vision patients suffering from blindness caused by age-related macular degeneration (AMD) or retinitis pigmentosa (RP). Up until now, most prostheses were powered using an inductive link coupled with cables penetrating through the eyeball. Although they efficiently power implant, limit long-term reliability and cause postoperative complications. A fully wireless near-infrared data entering eye pupil alleviates these issues but limits available causes...
Abstract Objective. Time-of-flight (TOF) scatter rejection allows for identifying and discarding scattered photons without the use of an anti-scatter grid (ASG). Although TOF was initially presented cone-beam computed tomography, we propose, herein, to extend this approach x-ray radiography. This work aims evaluate with simulations if can outperform ASGs Approach. GATE used simulate radiography a head torso water cylinder bone inserts in system total timing jitters from 0 ps up 500...
Thirty consecutive lactate-sensitive panic disorder patients were studied with magnetic resonance imaging (MRI) to investigate the relationship between temporal lobe abnormalities and disorder. Neuroanatomical abnormalities, most involving right lobe, found in 43% of patients, compared 10% control subjects. Patients significantly younger at onset had more attacks normal MRI scans (p less than .05). These results suggest that could be secondary dysfunctions abnormal MRIs have a worse...
To address modern molecular imaging requirements, a digital positron emission tomography (PET) scanner for small animals has been developed at Universite de Sherbrooke. Based on individual readout of avalanche photodiodes (APD) coupled to LYSO/LGSO phoswich detectors, the supports up 4608 channels in 16.2 cm diameter, 11.25 axial field view with an isotropic ~ 1.2 mm FWHM intrinsic spatial resolution center view. Custom data acquisition boards preprocess and sample APD signals 45 MHz compute...
Future tonne-scale liquefied noble gas detectors depend on efficient light detection in the VUV range. In past years Silicon Photomultipliers (SiPMs) have emerged as a valid alternative to standard photomultiplier tubes or large area avalanche photodiodes. The next generation double beta decay experiment, nEXO, with 5 tonne liquid xenon time projection chamber, will use SiPMs for detecting $178\,\text{nm}$ scintillation light, order achieve an energy resolution of $\sigma / Q_{\beta\beta} =...
Time-of-flight measurements are becoming essential to the advancement of several fields, such as preclinical positron emission tomography and high energy physics. Recent developments in single photon avalanche diode (SPAD)-based detectors have spawned a great interest digital silicon photomultipliers (dSiPMs). To overcome tradeoff between photosensitive area processing capabilities current 2-D dSiPM, we propose novel 3-D SiPM, where SPAD, designed for maximal area, will be stacked over...