A5017359269- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Thermoregulation and physiological responses
- Muscle metabolism and nutrition
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Sports Performance and Training
- Circadian rhythm and melatonin
- Infrared Thermography in Medicine
- Fatty Acid Research and Health
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Sleep and related disorders
- Spaceflight effects on biology
- Health, Environment, Cognitive Aging
- Adrenal Hormones and Disorders
- Dialysis and Renal Disease Management
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Hormonal and reproductive studies
- Hormonal Regulation and Hypertension
- Lipid metabolism and biosynthesis
- Sleep and Wakefulness Research
- Mitochondrial Function and Pathology
- Climate Change and Health Impacts
Centre Hospitalier Universitaire de Sherbrooke
2016-2025
Université de Sherbrooke
2016-2025
University of Ottawa
2009-2022
Health Sciences Centre
2019-2022
Heinrich Heine University Düsseldorf
2013-2014
Düsseldorf University Hospital
2014
Montfort Hospital
2010-2012
Brown adipose tissue (BAT) is vital for proper thermogenesis during cold exposure in rodents, but until recently its presence adult humans and contribution to human metabolism were thought be minimal or insignificant. Recent studies using PET with 18F-fluorodeoxyglucose (18FDG) have shown the of BAT humans. However, whether contributes cold-induced nonshivering has not been proven. Using 11C-acetate, 18FDG, 18F-fluoro-thiaheptadecanoic acid (18FTHA), a fatty tracer, we quantified oxidative...
Recent studies examining brown adipose tissue (BAT) metabolism in adult humans have provided convincing evidence of its thermogenic potential and role clearing circulating glucose fatty acids under acute mild cold exposure. In contrast, early indications suggest that BAT is defective obesity type 2 diabetes, which may important pathological therapeutic implications. Although many mammalian models demonstrated the phenotypic flexibility this through chronic exposure, little known about...
Both brown adipose tissue (BAT) and skeletal muscle activation contribute to the metabolic response of acute cold exposure in healthy men even under minimal shivering. Activation intracellular lipolysis is associated with BAT upon men. Although glucose uptake per volume important, bulk turnover during mediated by when shivering minimized.Cold stimulates sympathetic nervous system (SNS), triggering cold-defence responses mobilizing substrates fuel thermogenic processes. these processes have...
Spontaneous glucose uptake by brown adipose tissue (BAT) is lower in overweight or obese individuals and diabetes. However, BAT metabolism has not been previously investigated patients with type 2 diabetes during controlled cold exposure. Using positron emission tomography 11C-acetate, 18F-fluoro-deoxyglucose (18FDG), 18F-fluoro-thiaheptadecanoic acid (18FTHA), a fatty tracer, oxidative perfusion nonesterified (NEFA) turnover were determined men well-controlled age-matched control subjects...
Caloric restriction that promotes weight loss is an effective strategy for treating non-alcoholic fatty liver disease and improving insulin sensitivity in people with type 2 diabetes1. Despite its effectiveness, most individuals, usually not maintained partly due to physiological adaptations suppress energy expenditure, a process known as adaptive thermogenesis, the mechanistic underpinnings of which are unclear2,3. Treatment rodents fed high-fat diet recombinant growth differentiating...
Abstract In rodents, brown adipose tissue (BAT) plays an important role in producing heat to defend against the cold and can metabolize large amounts of dietary fatty acids (DFA). The BAT DFA metabolism humans is unknown. Here we show that mild stimulation (18 °C) results a significantly greater fractional extraction by relative skeletal muscle white non-cold-acclimated men given standard liquid meal containing long-chain acid PET tracer, 14( R , S )-[ 18 F]-fluoro-6-thia-heptadecanoic (...
Muscle-derived thermogenesis during acute cold exposure in humans consists of a combination cold-induced increases skeletal muscle proton leak and shivering. Daily results an increase brown adipose tissue oxidative capacity coupled with decrease the shivering intensity. Improved coupling between electromyography-determined activity whole-body heat production following acclimation suggests maintenance ATPase-dependent ATPase independent thermogenesis. Although daily did not change fibre...
While brown adipose tissue (BAT) is activated by the beta-3-adrenergic receptor (ADRB3) in rodents, human adipocytes, ADRB2 dominantly present and responsible for noradrenergic activation. Therefore, we performed a randomized double-blinded crossover trial young lean men to compare effects of single intravenous bolus agonist salbutamol without with ADRB1/2 antagonist propranolol on glucose uptake BAT, assessed dynamic 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography-computed...
Psychological stress changes both behaviour and metabolism to protect organisms. Adrenaline is an important driver of this response. Anxiety correlates with circulating free fatty acid levels can be alleviated by a peripherally restricted β-blocker, suggesting peripheral signal linking behaviour. Here we show that adrenaline, the β3 agonist CL316,243 acute restraint induce growth differentiation factor 15 (GDF15) secretion in white adipose tissue mice. Genetic inhibition triglyceride lipase...
Daily compensable cold exposure in humans reduces shivering by ~20% without changing total heat production, partly increasing brown adipose tissue thermogenic capacity and activity. Although acclimation acclimatization studies have long suggested that daily reductions core temperature are essential to elicit significant metabolic changes response repeated exposure, this has never directly been demonstrated. The aim of the present study is determine whether cold-water immersion, resulting a...
In rodents, lower brown adipose tissue (BAT) activity is associated with greater liver steatosis and changes in the gut microbiome. However, little known about these relationships humans. adults (n = 60), we assessed hepatic fat cold-stimulated BAT using magnetic resonance imaging microbiota 16S sequencing. We transplanted gnotobiotic mice feces from humans to assess transferability of through microbiota. Individuals NAFLD 29) have than those without, inversely related content. not...
Diets rich in added sugars are associated with metabolic diseases, and studies have shown a link between these pathologies changes the microbiome. Given reported associations animal models microbiome brown adipose tissue (BAT) function, alterations induced by high-glucose or high-fructose diets, we investigated potential causal -fructose diets BAT dysfunction humans. Primary outcomes cold-induced thermogenesis fecal (clinicaltrials.gov, NCT03188835). We show that glucose uptake, but not...
In rodents, loss of estradiol (E
Current paradigms for predicting weight loss in response to energy restriction have general validity but a subset of individuals fail respond adequately despite documented diet adherence. Patients the bottom 20% rate following hypocaloric (diet-resistant) been found less type I muscle fibres and lower skeletal mitochondrial function, leading hypothesis that physical exercise may be an effective treatment when alone is inadequate. In this study, we aimed assess efficacy training on function...