A5000374577- Adipose Tissue and Metabolism
- Alzheimer's disease research and treatments
- Diet and metabolism studies
- Dietary Effects on Health
- Tryptophan and brain disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Muscle Physiology and Disorders
- Cardiomyopathy and Myosin Studies
- Metabolism, Diabetes, and Cancer
- Muscle metabolism and nutrition
- Nerve injury and regeneration
- Lymphoma Diagnosis and Treatment
- Autism Spectrum Disorder Research
- Acute Lymphoblastic Leukemia research
- Plant tissue culture and regeneration
- Muscle activation and electromyography studies
- Vector-borne infectious diseases
- Gut microbiota and health
- Genetic Neurodegenerative Diseases
- Stress Responses and Cortisol
- Cutaneous lymphoproliferative disorders research
- Autoimmune and Inflammatory Disorders Research
- Dermatological diseases and infestations
- Genetic Syndromes and Imprinting
- Trypanosoma species research and implications
Brock University
2018-2025
McMaster University
2022-2025
Population Health Research Institute
2024-2025
Digestive Health Research Institute
2024
McMaster University Medical Centre
2024
University of Manitoba
2017-2023
Silicon Austria Labs (Austria)
2023
Manitoba Health
2021
Diagnostic Services Manitoba
2015
University of North Sumatra
2015
Exercise reduces cognitive aging, neurodegeneration, and Alzheimer's disease (AD) risk. Acute exercise the activity of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1), rate-limiting in production Aβ. However, mechanisms mediating these effects remain largely unknown. Work has implicated brain-derived neurotrophic factor (BDNF) processing protein (APP). BDNF is an exercise-induced neurotrophin known for its role synaptic plasticity, neurite growth, neuronal survival. Previously,...
Abstract This study, in vivo and vitro, investigated the role of brain‐derived neurotrophic factor (BDNF) skeletal muscle adaptations to aerobic exercise. BDNF is a contraction‐induced protein that may play involved repair, increased fat oxidation, mitochondrial biogenesis, all which are observed with training. The purpose this study was two‐pronged response (1) acute (2) chronic exercise male C57BL/6J mice. It also examined if treatment resulted similar In aim 1, mice underwent 2 hr....
Chronic low-level inflammation or "inflammaging" is hypothesized to contribute sarcopenia and frailty. Resident microbiota are thought promote inflammaging, frailty, loss of skeletal muscle mass. We tested immunity frailty in male C57BL6/N germ-free (GF), specific-pathogen-free (SPF), mice that were born colonized (COL) with an SPF microbiota. Male female GF had lower systemic cellular indicated by blood Ly6Chigh monocytes across their lifespan. body mass, but relative smaller hindlimb...
Psychological stress changes both behaviour and metabolism to protect organisms. Adrenaline is an important driver of this response. Anxiety correlates with circulating free fatty acid levels can be alleviated by a peripherally restricted β-blocker, suggesting peripheral signal linking behaviour. Here we show that adrenaline, the β3 agonist CL316,243 acute restraint induce growth differentiation factor 15 (GDF15) secretion in white adipose tissue mice. Genetic inhibition triglyceride lipase...
Perturbations in metabolism results the accumulation of beta-amyloid peptides, which is a pathological feature Alzheimer’s disease. Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) rate limiting responsible for production. Obesogenic diets increase BACE1 while exercise reduces activity, although mechanisms are unknown. Brain-derived neurotropic factor (BDNF) an inducible neurotrophic factor, however, it unknown if BDNF related to effects on BACE1. The purpose this study was...
Interleukin-6 (IL-6) is a pleiotropic cytokine that can be released from the brain during prolonged exercise. In peripheral tissues, exercise induced IL-6 result in GLUT4 translocation and increased glucose uptake through AMPK activation. expressed recruited to axonal plasma membranes with neuronal activity The aim of this study examine if treatment: (1) results activation cells, (2) increases proteins involved translocation, (3) uptake. Retinoic acid was used differentiate SH-SY5Y cells....
Sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) uncoupling in skeletal muscle and mitochondrial via protein 1 (UCP1) brown/beige adipose tissue are two mechanisms implicated energy expenditure. Here, we investigated the effects of glycogen synthase kinase 3 (GSK3) inhibition lithium chloride (LiCl) treatment on SERCA UCP1 expression adipose. C2C12 3T3-L1 cells treated with LiCl had increased levels, respectively, ultimately raising cellular respiration; however, this was only observed when...
The DBA/2J (D2) mdx mouse is a more severe model of Duchenne muscular dystrophy when compared to the traditional C57BL/10 (C57) mouse. Here, we questioned whether sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) function would differ in muscles from young D2 and C57 mice. Both mice exhibited signs impaired Ca2+ uptake gastrocnemius, diaphragm, left ventricle; however, level impairment was Reductions maximal SERCA activity were also prominent gastrocnemius diaphragm those mice; there no...
Neurodegenerative diseases such as Alzheimer’s disease (AD) are becoming more prevalent in our aging society. One specific neuropathological hallmark of this is the accumulation amyloid-β (Aβ) peptides, which aggregate to form extraneuronal plaques. Increased Aβ peptides often observed well before symptoms AD develop, highlighting importance targeting Aβ-producing pathways early on progression. Evidence indicates that exercise has capacity reduce peptide production brain; however, mechanisms...
It is becoming evident that exercise modulates APP processing and can reduce amyloid-beta (Aβ) peptide production. Our data help to explain this phenomenon by highlighting IL-6 as an exercise-induced factor lowers pathological processing. These results also highlight brain regional differences in response acute IL-6.
We show that a 5:2 intermittent fasting regimen can increase lipid oxidation without altering body mass in lean mice. Therefore, repeated metabolic flexibility the need for (or prior to) weight loss. Intermittent did not mice with obesity and type 2 diabetes, highlighting and/or diabetes limit changes mitigate increased fatty acid loss during fasting.
Lithium, a commonly used treatment for bipolar disorder, has been shown to have neuroprotective effects other conditions including Alzheimer's disease via the inhibition of enzyme glycogen synthase kinase-3 (GSK3). However, dose-dependent adverse lithium are well-documented, highlighting need determine if low doses can reliably reduce GSK3 activity.The purpose this study was evaluate low-dose supplementation on activity in brain an early, diet-induced model.Male C57BL/6J mice were divided...
Human granulocytic anaplasmosis is a rare, tick-borne infectious disease caused by Anaplasma phagocytophilum. Herein, we report rare case of human associated with cytopenias and clonal expansion gamma/delta T-cells in the bone marrow. A 77-year old man presented multiple times to emergency department complaining muscle weakness. Complete blood count detected peripheral smear showed pseudo Pelger-Huet neutrophils. These findings prompted marrow evaluation ancillary studies including flow...
Glucose is the primary metabolic substrate of neurons and responsible for supporting many vital functions including neuronal signalling. Decreases in glucose uptake utilization are common characteristics dementia, particularly Alzheimer's disease, thus agents that can restore availability may be especially valuable to field. Diets rich antioxidants polyphenols have been associated with reductions risk chronic disease aging. In previous studies, rosemary extract (RE) has reported antioxidant,...
The present report documents a 49‐year‐old HIV‐infected man receiving antiretroviral therapy with suboptimal immune response and CD4 count of 95 cells/mm 3 , despite virological suppression. Investigation bone marrow was conducted yielded diagnosis visceral leishmaniasis. clinical course complicated by gastrointestinal involvment relapse occurred after amphotericin B therapy. With the addition miltefosine, patient no longer presented amastigotes, displayed an increased negative Leishmania...
After menopause, women experience declines in ovarian sex hormones, an event that has recently been associated with increased amyloid-β peptides, a main feature of Alzheimer's disease. Diet-induced insulin resistance also increases peptides; however, whether this process is exacerbated hormone loss remains unknown. Female C57BL6/J mice received either bilateral ovariectomy (OVX; n = 20) or remained intact (n at 24 wk age and were placed on low- high-fat diet (LFD, 10 for OVX intact; HFD,...