A5078550857- Developmental Biology and Gene Regulation
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Mitochondrial Function and Pathology
- Click Chemistry and Applications
- Joseph Conrad and Literature
- Marine Ecology and Invasive Species
- Bacterial Genetics and Biotechnology
- Historical Philosophy and Science
- Seventeenth-Century Political and Philosophical Thought
- Porphyrin and Phthalocyanine Chemistry
- Reformation and Early Modern Christianity
- Hemoglobin structure and function
- Bacteriophages and microbial interactions
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Photochromic and Fluorescence Chemistry
- Exercise and Physiological Responses
- Cancer-related gene regulation
- Metabolism and Genetic Disorders
- Adipose Tissue and Metabolism
- Invertebrate Immune Response Mechanisms
- Neurobiology and Insect Physiology Research
- Genetic Neurodegenerative Diseases
- CRISPR and Genetic Engineering
Brock University
2017-2024
Abstract The Notch receptor is a pleiotropic signaling protein that translates intercellular ligand interactions into changes in gene expression via the nuclear localization of intracellular Domain (NICD). Using combination immunohistochemistry, RNA situ , Optogenetics and super-resolution live imaging transcription human cells, we show N1ICD can form condensates positively facilitate target expression. We determined undergoes Phase Separation Coupled Percolation (PSCP) transcriptional...
Interleukin-6 (IL-6) is a pleiotropic cytokine that can be released from the brain during prolonged exercise. In peripheral tissues, exercise induced IL-6 result in GLUT4 translocation and increased glucose uptake through AMPK activation. expressed recruited to axonal plasma membranes with neuronal activity The aim of this study examine if treatment: (1) results activation cells, (2) increases proteins involved translocation, (3) uptake. Retinoic acid was used differentiate SH-SY5Y cells....
The discovery of fluorescence two centuries ago ushered in, what is today, an illuminating field science rooted in the rational design photochromic molecules for task-specific bio-, material-, and medical-driven applications. Today, this includes applications bioimaging diagnosis, photodynamic therapy regimes, addition to photovoltaic devices solar cells, among a vast multitude other usages. In furthering indispensable area daily life modern-day scientific research, we report herein...
Drosophila melanogaster has been used as a model system to identify and characterize genetic contributions development, homeostasis, investigate the molecular determinants of numerous human diseases. While there exist many differences at genetic, structural, level, signalling components cellular machineries are conserved between humans. For this reason, can extensively model, study pathologies. The extensive resources available make powerful one. Over years, sophisticated rapidly expanding...
With advancements in multicomponent molecular biological tools, the need for versatile, rapid and cost-effective cloning that enables successful combinatorial assembly of DNA plasmids interest is becoming increasingly important. Unfortunately, current platforms fall short regarding affordability, ease and, above all, ability to iteratively remove individual cassettes at will. Herein we construct, implement make available a broad set vectors, called PlayBack allow expression several different...
Retinoic acid, the active metabolite of Vitamin A, is important for appropriate development nervous system (e.g., neurite outgrowth) as well cognition memory formation) in adult brain. We have shown that many effects retinoids are conserved CNS mollusc, Lymnaea stagnalis. RXRs predominantly nuclear receptors, but RXR (LymRXR) exhibits a non-nuclear distribution CNS, where it also implicated non-genomic retinoid functions. As such, we developed Drosophila organ culture-based to examine...
Abstract Notch signaling is a critical regulator of multiple developmental processes through its ability to control gene expression, and thereby influence cell fate specification proliferation, direct cell-cell communication. Although signalling has been implicated in myogenesis during late embryogenesis, the role early mesoderm development largely unexplored. Endocytosis ligand Delta receptor extracellular domain, step pathway activation, extensively observed ventral Drosophila embryo,...
The Notch receptor is a pleiotropic signaling protein that translates intercellular ligand interactions into changes in gene expression
Abstract Notch signaling is a critical regulator of multiple developmental processes through its ability to control gene expression, and thereby influence cell fate specification proliferation direct cell-cell communication. Although signalling has been implicated in myogenesis during late embryogenesis, the role early mesoderm development largely unexplored. Endocytosis ligand receptor extracellular domain observed mesectoderm therefore indicative activity. Here we present evidence that...
Research Article| January 01 2010 “Macbeth” and the Political Uncanny in “The Tenure of Kings Magistrates” Gregory Foran Search for other works by this author on: This Site Google Milton Studies (2010) 51: 1–20. https://doi.org/10.2307/26396000 Cite Icon Share Twitter Permissions Citation Foran; Magistrates”. 1 2010; 51 doi: Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Dropdown Menu input auto suggest filter your All...