A5100671132- Clinical Laboratory Practices and Quality Control
- Metabolomics and Mass Spectrometry Studies
- Metabolism and Genetic Disorders
- Hormonal and reproductive studies
- Hormonal Regulation and Hypertension
- Pesticide Residue Analysis and Safety
- Diabetes Management and Research
- Meta-analysis and systematic reviews
- Analytical Chemistry and Chromatography
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Traditional Chinese Medicine Studies
- Chronic Kidney Disease and Diabetes
- Adrenal Hormones and Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes and associated disorders
- Renal function and acid-base balance
- Statistical Methods in Clinical Trials
- Pharmacogenetics and Drug Metabolism
- Vitamin D Research Studies
- Biosimilars and Bioanalytical Methods
- Folate and B Vitamins Research
- Hemodynamic Monitoring and Therapy
- Bacterial Identification and Susceptibility Testing
- Health Systems, Economic Evaluations, Quality of Life
- Adrenal and Paraganglionic Tumors
Nanjing Medical University
2022-2025
Jiangsu Province Hospital
2022-2025
Zhengzhou University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
National Center for Clinical Laboratories
2015-2024
Beijing Hospital
2009-2024
University of Macau
2021-2024
Peking Union Medical College Hospital
2015-2023
Berkeley College
2023
University of California, Berkeley
2023
Riboflavin-5-phosphate (RF) is the most commonly used photosensitizer in corneal cross-linking (CXL), but its hydrophilicity and negative charge limit penetration through epithelium into stroma. To enhance permeability of RF promote efficacy treatment keratoconus, novel hibiscus-like RF@ZIF-8 microsphere composites [6RF@ZIF-8 NF (nanoflake)] are prepared using ZIF-8 nanomaterials as carriers, which characterized by their hydrophobicity, positive potential, biocompatibility, high loading...
Abstract Background In previous publications, the Task Force on Reference Measurement System Implementation proposed a procedural approach combining critical review of entries available in Joint Committee Traceability Laboratory Medicine (JCTLM) database with comparison this information against analytical performance specifications for measurement uncertainty (MU) and applied it to group 13 measurands. Content Here we 17 additional measurands, which measurements are frequently requested. The...
Restoration of independent walking ability is the primary objective stroke rehabilitation; however, not all patients achieve this goal due to diverse impairments in paretic lower limb and compensatory mechanisms that lead an asymmetrical mechanically inefficient gait. This investigation aimed examine alterations cortical activation post-stroke while with a wearable two-channel functional electrical stimulation (FES) comparison without FES. observational study was conducted discern distinct...
The JCTLM created a Task Force on Reference Measurement System Implementation (TF-RMSI) to provide guidance metrological traceability implementation for the in vitro diagnostics (IVD) community.TF-RMSI investigated reference measurement systems (RMS) 13 common measurands by applying following procedural steps: (a) extracting data from database of available certified materials (CRMs) and procedures (RMPs); (b) describing RMS which each recruited CRM or RMP belongs; (c) identifying intended...
Abstract Objectives The standardization of cystatin C (CysC) measurement has received increasing attention in recent years due to its importance estimating glomerular filtration rate (GFR). Mass spectrometry-based assays have the potential provide an accuracy base for CysC measurement. However, a precise, accurate and sustainable LC–MS/MS method is still lacking. Methods developed quantified by detecting signature peptide (T3) obtained from tryptic digestion. Stable isotope labeled T3...
Abstract Introduction Two approaches were compared for the calculation of coefficient variation (CV) and bias, their effect on sigma calculation, when different allowable total error (TEa) values used to determine optimal method Six Sigma quality management in clinical laboratory. Materials methods metrics routine chemistry tests using three systems (Beckman AU5800, Roche C8000, Siemens Dimension) determined June 2017 laboratory Peking Union Medical College Hospital. Imprecision (CV%) bias...
The vasoprotective drug calcium dobesilate is known to interfere with creatinine (Cr) quantifications in sarcosine oxidase enzymatic (SOE) assays. aim of this study was investigate interference 8 different commercially available assays and determine its clinical significance. In vitro experiments, evaluated at 3 Cr levels. For this, quantified by SOE pooled serum supplemented final concentrations 0, 2, 4, 8, 16, 32, 64 μg/mL. Percent bias calculated relative the drug-free specimen. vivo...
Functional near-infrared spectroscopy (fNIRS) is a non-invasive and promising tool to map the brain functional networks in stroke recovery. Our study mainly aimed use fNIRS detect different patterns of resting-state connectivity (RSFC) subacute patients with degrees upper extremity motor impairment defined by Fugl-Meyer assessment (FMA-UE). The second aim was investigate association between FMA-UE scores fNIRS-RSFC among regions interest (ROIs) patients.Forty-nine (2 weeks-6 months)...
The total flavonoids of Desmodium styracifolium are the flavonoid extracts purified from Desmodii Styracifolii Herba, which has conventionally been used for treating urolithiasis in China. In this study, a sensitive and simple liquid chromatography-tandem mass spectrometry method was developed to simultaneously determine five active components rat plasma. Chromatographic separation analytes (schaftoside, vicenin-1, vicenin-2, vicenin-3, isovitexin) performed on an ACQUITY UPLC HSS T3 Column...
Background We aimed to evaluate the commutability of external quality assessment (EQA) materials, aqueous solutions, and commercial reference materials (calibrators controls), accuracy routine systems for serum triglyceride measurements. Methods According clinical laboratory standards institute (CLSI) EP14-A3 protocol, we analyzed 43 fresh patient specimens 32 processed including lyophilized samples, human pools, liquid reagents, swine sera solutions by 14 methods (evaluated methods) an...
Abstract In this study, we analyzed frozen sera with known commutabilities for standardization of serum electrolyte measurements in China. Fresh were sent to 187 clinical laboratories China measurement four electrolytes (sodium, potassium, calcium, and magnesium). Target values assigned by two reference laboratories. Precision (CV), trueness (bias), accuracy [total error (TE About half the used a homogeneous system (same manufacturer instrument, reagent calibrator) calcium magnesium...
Yuhang Deng, M.D., Chao Zhang, Jing Wang, M.M., Jie Zeng, Jiangtao Tianjiao Haijian Zhao, Weiyan Zhou, and Chuanbao M.D.. Ann Lab Med 2023;43:345-54. https://doi.org/10.3343/alm.2023.43.4.345
Lewy body diseases (LBD) comprise a group of complex neurodegenerative conditions originating from accumulation misfolded alpha-synuclein (α-syn) in the form bodies. LBD pathologies are characterized by α-syn deposition association with other proteins such as Amyloid β (Aβ), Tau, and TAR-DNA-binding protein. To investigate interactions these proteins, we constructed 2 novel transgenic overexpressing (OE) C. elegans strains (α-syn
Serum sodium and magnesium are important clinical laboratory tests accurate testing results needed for the correct interpretation of tests. Standardization serum measurements requires simple reliable reference methods.Inductively coupled plasma mass spectrometry (ICP-MS) methods measurement were developed. Aluminum was used as an internal standard. samples spiked with standard, digested 69% nitric acid at 150 degrees C measured 23Na/27Al 24Mg/27Al ratios by ICP-MS. The calibrated bracketing...
PURPOSE: To assess the precision of a new spectral-domain optical coherence tomographer (SD-OCT)/Placido topographer (MS-39; CSO) and its comparison with swept-source OCT (SS-OCT) biometer (Argos; Movu, Inc) in patients cataract. METHODS: Fifty-three right eyes from 53 were examined by two experienced operators three times using both devices randomly. Employing within-subject standard deviation (S w ), test–retest variability, coefficient variation, intraclass correlation to evaluate...