A5063000955- Neuroscience and Neuropharmacology Research
- Genetics, Aging, and Longevity in Model Organisms
- Gene expression and cancer classification
- MicroRNA in disease regulation
- Bioinformatics and Genomic Networks
- Parkinson's Disease Mechanisms and Treatments
- Ion channel regulation and function
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Receptor Mechanisms and Signaling
- RNA regulation and disease
- Neurotransmitter Receptor Influence on Behavior
- Nerve injury and regeneration
- Memory and Neural Mechanisms
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- Synthesis and pharmacology of benzodiazepine derivatives
- Neurogenesis and neuroplasticity mechanisms
- Nanoparticles: synthesis and applications
- Genomics and Phylogenetic Studies
- Cannabis and Cannabinoid Research
- RNA Research and Splicing
- Birth, Development, and Health
- Advanced biosensing and bioanalysis techniques
- Selenium in Biological Systems
University of Macau
2016-2025
University of Eastern Finland
2007-2016
Finland University
2011-2013
Biocenter Finland
2011
San Francisco VA Medical Center
2011
Institut thématique Génétique, génomique et bioinformatique
2011
Kuopio University Hospital
2010
Institute for Molecular Science
2005-2008
Washington University in St. Louis
1999
National Institutes of Health
1987-1998
DNA microarray technologies together with rapidly increasing genomic sequence information is leading to an explosion in available gene expression data. Currently there a great need for efficient methods analyze and visualize these massive data sets. A self-organizing map (SOM) unsupervised neural network learning algorithm which has been successfully used the analysis organization of large files. We have here applied SOM published yeast show that excellent tool visualization profiles.
Overexpression of human alpha-synuclein in model systems, including cultured neurons, drosophila and mice, leads to biochemical pathological changes that mimic synucleopathies Parkinson's disease. We have overexpressed both wild-type (WT) mutant alanine53-->threonine (A53T) by transgenic injection into Caenorhabditis elegans. Motor deficits were observed when either WT or A53T was with a pan-neuronal motor neuron promoter. Neuronal dendritic loss accelerated all three sets C. elegans...
We detected the transgenerational toxicity of nanopolystyrene particles in range μg L<sup>−1</sup>in nematodes.
Aneurysmal subarachnoid hemorrhage, almost always from saccular intracranial aneurysm (sIA), is a devastating form of stroke that affects the working-age population. Cellular and molecular mechanisms predisposing to rupture sIA wall are largely unknown. This knowledge would facilitate design novel diagnostic tools therapies for disease.To investigate gene expression patterns distinguishing ruptured unruptured sIA.We compared whole-genome profile 11 samples with 8 ones using oligonucleotide...
Brain-derived neurotrophic factor (BDNF) signaling through its receptor TRKB modulates survival, differentiation, and activity of neurons. BDNF activates on the cell surface, which leads to initiation intracellular cascades different biological responses in Neuronal has been shown regulate levels plasma membrane neurons, but little is known about other factors affecting surface expression levels. We report here that regulates transfected or endogenously expressed full-length TRKB, depending...
Methylmercury (MeHg) exposure from occupational, environmental, and food sources is a significant threat to public health. MeHg poisonings in adults may result severe psychological neurological deficits, utero exposures can confer embryonic defects developmental delays. Recent epidemiological vertebrate studies suggest that also contribute dopamine (DA) neuron vulnerability the propensity develop Parkinson's disease (PD). In this study, we describe Caenorhabditis elegans model of toxicity...
Blood-based gene expression or epigenetic biomarkers of Parkinson's disease (PD) are highly desirable. However, accuracy and specificity need to be improved, methods for the integration with data developed in order make this feasible. Whole blood DNA methylation were downloaded from Gene Expression Omnibus (GEO) database. A linear model was used identify significantly differentially expressed genes (DEGs) methylated (DMGs) according specific regions 5′—C—phosphate—G—3′ (CpGs) all CpGs PD....
Weighted gene co-expression network analysis (WGCNA) is used to detect clusters with highly correlated genes. Measurements of correlation most typically rely on linear relationships. However, a relationship does not always model pairwise functional-related dependence between In this paper, we first compared 6 different methods in their ability capture complex genes three tissues. Next, gene-pairwise coefficient results and corresponding WGCNA results. Finally, applied recently proposed...
Abstract Nematodes compose an abundant and diverse invertebrate phylum with members inhabiting nearly every ecological niche. Panagrellus redivivus (the “microworm”) is a free-living nematode frequently used to understand the evolution of developmental behavioral processes given its phylogenetic distance Caenorhabditis elegans. Here we report de novo sequencing genome, transcriptome, small RNAs P. redivivus. Using combination automated gene finders RNA-seq data, predict 24,249 genes 32,676...
Abstract PIWI-interacting RNAs (piRNAs) are small noncoding that regulate gene expression, yet their molecular functions in neurobiology unclear. While investigating neurodegeneration mechanisms using human α-syn(A53T) Tg and Aβ ;α-syn(A53T) pan-neuronal overexpressing strains, we unexpectedly observed dysregulation of piRNAs. RNAi screening revealed knock down piRNA biogenesis genes improved thrashing behavior; further, a tofu-1 deletion ameliorated phenotypic deficits transgenic strains....
Piwi-interacting RNAs (piRNAs) are well established for monitoring and protecting the genome from transposons in germline cells. Recently, numerous studies provided evidence that piRNAs also play important roles regulating mRNA transcript levels. Despite their significant role cellular RNA levels, piRNA targeting rules not defined, especially mammals, which poses obstacles to elucidation of function. Given complexity current limitation understanding mammalian rules, we designed a deep...