A5050108568- Synthesis and Biological Evaluation
- Advanced Nanomaterials in Catalysis
- Pesticide and Herbicide Environmental Studies
- Retinal Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Electrochemical sensors and biosensors
- Acute Myocardial Infarction Research
- Weed Control and Herbicide Applications
- Metal-Catalyzed Oxygenation Mechanisms
- Nematode management and characterization studies
- Click Chemistry and Applications
- Geochemistry and Elemental Analysis
- Esophageal Cancer Research and Treatment
- Oxidative Organic Chemistry Reactions
- Nanoplatforms for cancer theranostics
- Venous Thromboembolism Diagnosis and Management
- Radioactive element chemistry and processing
- Microplastics and Plastic Pollution
- Pharmacogenetics and Drug Metabolism
- Composting and Vermicomposting Techniques
- Computational Drug Discovery Methods
- Heme Oxygenase-1 and Carbon Monoxide
- Metal complexes synthesis and properties
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Traditional Chinese Medicine Analysis
Changhai Hospital
2023-2025
Second Military Medical University
2023-2025
Huazhong Agricultural University
2021-2025
Qilu University of Technology
2025
Shandong Academy of Sciences
2025
Chinese Academy of Surveying and Mapping
2024
First Affiliated Hospital of Henan University of Science and Technology
2016-2021
Northeast Agricultural University
2019-2021
Binzhou People's Hospital
2019
4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) is an important target site for discovering new bleaching herbicides. To explore novel HPPD inhibitors with excellent herbicidal activity, a series of N-aroyl diketone/triketone derivatives were rationally designed by splicing active groups and bioisosterism. Bioassays revealed that most these displayed preferable activity against Echinochloa crus-galli (EC) at 0.045 mmol/m2 Abutilon juncea (AJ) 0.090 mmol/m2. In particular, compound...
Tribenuron-methyl (TM), as one of the sulfonylurea (SU) herbicides, has been widely and effectively applied for many kinds plants. SUs inhibit plant growth by restraining biosynthetic pathway branched-chain amino acids (BCAAs) catalyzed acetolactate synthase (ALS). Safeners are agrochemicals that protect crops from herbicide injuries. To improve crop tolerance under TM toxicity stress, this paper evaluated protective effect N-tosyloxazolidine-3-carboxamide. It turned out most tested...
Herbicide safeners selectively protect crops from herbicide damage without reducing the herbicidal efficiency on target weed species. The title compounds were designed by intermediate derivatization approach and fragment splicing to exploit novel potential safeners. A total of 31 diazabicyclo derivatives synthesized microwave-assistant method using isoxazole-4-carbonyl chloride derivatives. All synthetic confirmed infrared, 1H 13C nuclear magnetic resonance, high-resolution mass...
Root-knot nematodes (RKNs) are harmful plant-parasitic that cause serious damage to plant hosts. In the long-term practice of RKN management, bacterial nematicides have attracted increasing attention as an effective biocontrol means. Here we determined active substances against Meloidogyne incognita from a nematicidal bacterium, developed agent (BCA) based on optimized culture processes. The effects BCA control and growth-promotion were evaluated in tomato pot trials.Pseudomonas simiae...
Pathological retinal neovascularization (RNV) is one of the leading causes blindness worldwide; however, its underlying mechanism remains unclear. Here, we found that expression endothelial protein C receptor (Epcr) was increased during RNV, and ligand elevated in serum or vitreous body patients with proliferative diabetic retinopathy. Deleting Epcr using an EPCR-neutralizing antibody ameliorated pathological angiogenesis. EPCR promoted heme catabolism carbon monoxide release through...
Fucoidan is a fucose-rich sulfated polysaccharide that has gained attention owing to its various biological activities. In this study, fucoidan was isolated from Saccharina japonica using an enzyme-assisted method, and antioxidant anti-hepatocarcinoma effects were evaluated. The 112.8 kDa comprising seven monosaccharides: fucose, xylose, glucuronic acid, rhamnose, glucose, mannose, galactose. main chain residues (1 → 3)-α-L-Fucp 4)-α-L-Fucp units with sulfate groups at the C-2/C-4 positions...
Laminaria japonica is a kind of brown algal with good nutritional and medicinal value. Our previous studies demonstrated that the phytochemical components bioactivities were markedly enhanced by fermentation. However, specific activity underlying mechanism fermented (FLJ) against NAFLD remain poorly understood. For this study, was using S. cerevisiae Lactiplantibacillus . In vitro assays employed to evaluate efficacy FLJ in regulating cholesterol reduction fat binding. addition,...
This study aims to explore the mechanism by which selenium nanoparticles (SeNPs) inhibit retinal neovascularization (RNV) and identify a more effective treatment for pathological RNV. The characterization identification of synthesized were conducted investigate their effects on function human umbilical vein endothelial cells (HUVECs), blood vessel development in mice, impact oxygen-induced retinopathy. Tritium-labeled thymine was utilized label newly DNA both vivo vitro, allowing observation...
Abstract: The overexpression of programmed cell death-ligand 1(PD-L1) has been observed in gastric cancer (GC). However, whether the expression PD-L1 tumor cells or blood serum is associated with prognosis patients GC remains unclear. Therefore, we performed a meta-analysis to evaluate prognostic significance GC. Electronic databases were searched systematically. Studies that met inclusion criteria included meta-analysis. Data concerning hazard ratio (HR) for overall survival and...
Myocardial ischemia (MI) is a leading cause of morbidity and mortality which makes the prevention control MI tremendously important. We aimed to explore functional roles ginsenoside (Gin) Rg1 in cardiomyocytes under hypoxia clarify underlying mechanisms.Hypoxia-induced H9c2 cell injury was evaluated by alterations viability, apoptosis autophagy. Then, effects Gin on hypoxia-induced were measured. The activation phosphatidylinositol-3-kinase (PI3K)/AKT/mechanistic target rapamycin (mTOR)...
Ciprofloxacin (CIP), as a representative broad-spectrum antibiotic, poses major threat to human health and the ecological environment result of its abuse emissions. In this study, highly active Mn2+-oxidizing bacterium, Pseudomonas sp. CCTCC M2014168, was induced form micro-/nanostructured biogenic Mn oxide (BMO) aggregates through continuous culturing with 1 mmoL−1 Mn2+. Following characterization Mn4+ oxides micro-/nanostructures by scanning electron microscopy, high-resolution...
4-Hydroxyphenylpyruvate dioxygenase (HPPD) is a significant enzyme in the biosynthesis of plastoquinone and tocopherol, moreover, it also potential target to develop new herbicide. The computer-aided drug design (CADD) was employed efficient discovery HPPD inhibitors this study. Forty-three compounds with known activities were used generate CoMFA CoMSIA models based on common framework molecular docking. structural contribution activity determined which provided further information for novel...
Type VI secretion system (T6SS) is a potent weapon employed by various
4-Hydroxyphenylpyruvate dioxygenase (HPPD) is an iron-dependent non-heme oxygenase involved in the catabolic pathway of tyrosine, which important enzyme transformation 4-hydroxyphenylpyruvic acid to homogentisic acid, and thus being considered as herbicide target. Within this study, a set multiple structure-based pharmacophore models for HPPD inhibitors were developed. The ZINC natural product database virtually screened, 29 compounds obtained. binding mode its obtained through molecular...
Aim: 4-Hydroxyphenylpyruvate dioxygenase (HPPD) has attracted increasing attention as an important target against tyrosinemia type I. This paper aimed to explore the structure-activity relationship of HPPD inhibitors with pyrazole scaffolds and design novel inhibitors. Methodology & results: The best 3D-quantitative relationships model was established by two different strategies based on 40 scaffold-based analogs. Screening molecular fragments topomer technology, combined docking, 14...
To establish the prevalence and distribution profile of esophageal squamous cell carcinomas (ESCCs) over a 22-yr period in North China.Using endoscopy for primary diagnosis histological analysis further confirmation, total 74,854 ESCC patients aged 20-89 between January 1985 December 2006 were investigated to analyze epidemiological including rates, age-of-onset, gender geographical area Luoyang, highest incidence China.A 4092 cases finally diagnosed among who had their first endoscopies....
Purpose This study aims to report the CO 2 corrosion performance of 3Cr steel and 3Cr2Al reveal role aluminum in mitigating low-Cr steel. Design/methodology/approach Aluminum was added prepare a new type steel, effect on resistance pipeline studied using morphology observation composition analysis, weight loss tests electrochemical test. Findings In /O coexistence environment, average rate obviously lower than that The addition expanded range prepassivation, dynamic potential polarization...
Drug combinations could trigger pharmacological therapeutic effects (TEs) and adverse (AEs). Many computational methods have been developed to predict TEs, e.g. the synergy scores of anti-cancer drug combinations, or AEs from drug-drug interactions. However, most treated TEs predictions as two separate tasks, ignoring potential mechanistic commonalities shared between them. Based on previous clinical observations, we hypothesized that by learning learn underlying MoAs (mechanisms actions)...
To investigate the clinical effect of aspirin combined with clopidogrel on acute myocardial infarction after percutaneous coronary intervention (PCI).One hundred thirty two patients who were admitted to hospital between December 2016 and 2017 divided into a control group an observation according random number table, 66 each group. Both groups given emergency PCI symptomatic treatment. The was basis conventional treatment before operation, while same as lasted for 4 months. efficacy analyzed,...