A5007983961- Energetic Materials and Combustion
- Advanced Nanomaterials in Catalysis
- Alzheimer's disease research and treatments
- Retinal Diseases and Treatments
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Rocket and propulsion systems research
- Heme Oxygenase-1 and Carbon Monoxide
- Thermal and Kinetic Analysis
- Extracellular vesicles in disease
- Anaerobic Digestion and Biogas Production
- Ocular Oncology and Treatments
- Platelet Disorders and Treatments
- Cancer-related Molecular Pathways
- Graphene and Nanomaterials Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ubiquitin and proteasome pathways
- Bioinformatics and Genomic Networks
- Microbial Metabolic Engineering and Bioproduction
- Probabilistic and Robust Engineering Design
- Neuroinflammation and Neurodegeneration Mechanisms
- Biofuel production and bioconversion
- RNA Interference and Gene Delivery
Changhai Hospital
2021-2025
Second Military Medical University
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Northwestern Polytechnical University
2022-2024
Tianjin University of Traditional Chinese Medicine
2023-2024
Xinxiang Medical University
2024
National Clinical Research
2024
Shanghai Jiao Tong University
2024
Bridge University
2024
University of Shanghai for Science and Technology
2024
Wire arc additive manufacturing (WAAM) technology has attracted considerable interest in large-scale metallic components, but porosity and low deposition rate are the two dominating technical challenges WAAM of aluminum alloy. In order to effectively solve these problems, a novel method hot-wire is used fabricate Systematic studies carried out investigate formation mechanism pores, macro/microstructures, as well mechanical properties parts. It found that pores were mainly clustered at...
Engineering exosomes with nanomaterials usually leads to the damage of exosomal membrane and bioactive molecules. Here, pathological angiogenesis targeting magnetic imaging, ferroptosis inducing, immunotherapeutic properties is fabricated using a simple coincubation method macrophages being bioreactor. Extremely small iron oxide nanoparticle (ESIONPs) incorporated (ESIONPs@EXO) are acquired by sorting secreted from M1-polarized induced ESIONPs. ESIONPs@EXO suppress in vitro vivo without...
Pathological retinal angiogenesis resulting from a variety of ocular diseases including oxygen induced retinopathy, diabetic retinopathy and vein occlusion, is one the major reasons for vision loss, yet therapeutic option limited. Multiple nanoparticles have been reported to alleviate angiogenic retinopathy. However, adverse effect cannot be ignored due relatively large scale. Graphene quantum dots (GQDs) shown potential in drug delivery proved biocompatible. In this study, are extensively...
Black phosphorus quantum dots (BPQDs) have shown potential in tumor therapy, however, their anti-angiogenic functions not been studied. Although BPQDs are easily degraded to non-toxic phosphrous, the reported toxicity, poor stability, and non-selectivity largely limit further application medicine. In this study, a vascular targeting, biocompatible, cell metabolism-disrupting nanoplatform is engineered by incorporating into exosomes modified with Arg-Gly-Asp (RGD) peptide (BPQDs@RGD-EXO...
Pathological retinal neovascularization (RNV) is one of the leading causes blindness worldwide; however, its underlying mechanism remains unclear. Here, we found that expression endothelial protein C receptor (Epcr) was increased during RNV, and ligand elevated in serum or vitreous body patients with proliferative diabetic retinopathy. Deleting Epcr using an EPCR-neutralizing antibody ameliorated pathological angiogenesis. EPCR promoted heme catabolism carbon monoxide release through...
The characteristic of easy sintering aluminum nanoparticle (ANP) limits its application in solid propellants. Coating ANP with fluoropolymer could effectively improve combustion performance. To find out how the coating layer inhibits and promotes complete particles from an atomic view, a comparative study has been done for bare PTFE coated by using reactive molecular dynamics simulations. process is quantified shrinkage ratio gyration radius. Our results show that, at same heating rate...
While most research and treatments for multiple sclerosis (MS) focus on autoimmune reactions causing demyelination, it is possible that neurodegeneration precedes the response. Hence, glutamate receptor antagonists preventing excitotoxicity showed promise in MS animal models, though blocking signaling prevents critical neuronal functions. This study reports discovery of a small molecule AMPA-mediated by targeting an allosteric binding site. A machine learning approach was used to screen...
Abstract Accumulating evidence indicates that the actin regulator cofilin is overactivated in Alzheimer’s Disease (AD), but whether this abnormality contributes to synaptic and cognitive impairments AD unclear. In addition, brain region cell types involved remain unknown. study, we specifically manipulate LIMK1, key protein kinase phosphorylates inactivates cofilin, hippocampus of APP/PS1 transgenic mice. Using local injections AAV virus containing LIMK1 under control CaMKIIα promoter, show...
Polyvinylidene difluoride (PVDF) as a coating material for aluminum hydride (AlH 3 ) can improve its stability.