A5101693983- Antimicrobial Peptides and Activities
- Advancements in Transdermal Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Dermatology and Skin Diseases
- RNA Interference and Gene Delivery
- Metallic Glasses and Amorphous Alloys
- Nanoparticle-Based Drug Delivery
- Magnetic properties of thin films
- Topic Modeling
- Magnetic Properties and Applications
- Geochemistry and Geochronology of Asian Mineral Deposits
- Biochemical and Structural Characterization
- Dendrimers and Hyperbranched Polymers
- Computational and Text Analysis Methods
- Peptidase Inhibition and Analysis
- Psoriasis: Treatment and Pathogenesis
- Enzyme Catalysis and Immobilization
- Environmental Quality and Pollution
- Catalysis for Biomass Conversion
- Single-cell and spatial transcriptomics
- Plant Surface Properties and Treatments
- Bee Products Chemical Analysis
- Ocular Surface and Contact Lens
- Magnesium Alloys: Properties and Applications
- Advanced Nanomaterials in Catalysis
Shantou University Medical College
2019-2024
Shantou University
2019-2024
Jinan University
2023
Jiangsu Province Hospital
2023
Nanjing Medical University
2023
Yuntianhua Group (China)
2022
Arizona State University
2012
East China Normal University
2009
Since the emergence of Large Language Model (LLM), LLM has been widely used in fields such as writing, translating, and searching. However, there is still great potential for LLM-based methods handling complex tasks decision-making StarCraft II environment. To address problems lack relevant knowledge poor control over subtasks varying importance, we propose a Hierarchical Expert Prompt (HEP) LLM. Our method improves understanding game situations through expert-level tactical knowledge,...
StarCraft II is a complex and dynamic real-time strategy (RTS) game environment, which very suitable for artificial intelligence reinforcement learning research. To address the problem of Large Language Model(LLM) in environments through self-reflection, we propose Reflection Episodes(ROE) framework based on expert experience self-experience. This first obtains key information keyframe selection method, then makes decisions After completed, it reflects previous to obtain new Finally,...
Abstract Molecular architecture is a largely neglected and unexplored factor that could impart significant difference to the antimicrobial activity of peptides. In this article, advantages (i.e., improved charging effect enhanced proteolytic stability) star‐shaped poly( l ‐lysine)s (PLLs) over their linear analogs are extensively explored by methods computational simulation experiments. A series PEI‐ g ‐PLL with hyperbranched polyethylenimine (PEI) core PLL peripheral chains designed as...
Aim: Diabetic kidney disease (DKD) continues to be devastating complication of diabetes mellitus. Immune response and inflammatory reaction play essential roles in the progression DKD. But specific mechanism immune cells, their act on renal innate cells remains unclear. This article focused communication with provide bioinformatic evidence for further understanding Methods: Data were analyzed evaluate differentially expressed genes (DEGs) pathways DKD patients mice. Gene set enrichment...
Dissolving microneedles (MNs) have emerged as a promising transdermal delivery system, they integrate the advantages of both injection and preparations. However, low drug-loading limited efficiency MNs severely hinder their clinical applications. Microparticle-embedded gas-propelled were developed to simultaneously improve efficiency. The effects mold production technologies, micromolding formulation parameters on quality systematically studied. Three-dimensional printing technology was...
Psoriasis and diabetes are both common comorbidities for each other, where inflammation insulin resistance act in a vicious cycle, driving the progression of disease through activation NF-κB signaling pathway. Therefore, disrupting linkage between by inhibiting pathway presents promising therapeutic strategy addressing psoriasis-diabetic comorbidity. Herein, an open-loop therapy was developed integrating microneedle-mediated short- long-range missiles to target psoriasis diabetes,...
Abstract The development of narrow‐spectrum antimicrobial agents is paramount for swiftly eradicating pathogenic bacteria, mitigating the onset drug resistance, and preserving homeostasis bacterial microbiota in tissues. Owing to limited affinity between hydrophobic lipid bilayer interior cells most hydrophilic, polar peptides, construction a distinctive class four‐armed host‐defense peptides/peptidomimetics (HDPs) proposed with enhanced specificity membrane perturbation capability against...
With increasing human awareness of food safety, the replacement highly toxic pesticides with biocompatible antimicrobials has become a trend. This study proposes biocontrol microneedle (BMN) to expand application food-grade preservative epsilon-poly-L-lysine (ε-PL) in fruit preservatives by utilizing dissolving system. The macromolecular polymer ε-PL not only possesses broad-spectrum antimicrobial activity but also exhibits good mechanical properties. addition small amount polyvinyl alcohol,...
Superparamagnetic iron oxide (SPIO) nanocrystals have been extensively studied as theranostic nanoparticles to increase transverse (T
This paper introduces a new environment LLM-PySC2 (the Large Language Model StarCraft II Learning Environment), platform derived from DeepMind's Environment that serves to develop Models (LLMs) based decision-making methodologies. is the first offer complete action space, multi-modal observation interfaces, and structured game knowledge database, which are seamlessly connected with various LLMs facilitate research of LLMs-based decision-making. To further support multi-agent research, we...
Longitudinally driven giant magnetoimpedance (GMI) effect has been measured in Fe73.5Cu1Nb3Si13.5B9 ribbons, and the enhancement of GMI using magnetoelastic resonance was investigated. The results showed that at a certain frequency when occurred, there great impedance element MI effect. For ribbon 1.0 cm length annealed 480°C, maximum ratio 10 906% achieved 214 kHz. sensitivity reached up to 5 155%/Oe, which almost 40 times higher than observed traditional measurements. demonstrated enhanced...
To quantitatively investigate the effects of Ringer's solution with different concentrations alcohol (1%～80%) on biphasic compound action potentials (AP) from frog sciatic nerve trunk, and their recoveries effects.Individual segments trunk a length 6 to 8 cm were prepared. (0%, 1%, 2%, 4%, 8%, 16%, 32%, 48%, 64% 80%) was applied onto segment between stimulus ground electrodes via an agent reservoir which newly armed in shielded chamber for 5 minutes. The respectively electro-stimulated...
In article 1900147, Chuanbin Wu, Daojun Liu, Jianfeng Cai and co-workers design star-shaped poly(l-lysine)s as a class of versatile molecular scaffolds for the development multi-arm antimicrobial agents. The architecture is characterized by unique advantages such enhanced cationic charging density improved proteolytic stability, thus exhibiting high membrane binding, effective membrane-disruption unprecedented activity in vitro vivo.
Objective To quantitatively analyze the effects of direct and indirect stimuli on contraction gastrocnemius in vivo vitro specimen by self-programming. Methods All specimens were divided into four groups: group (n=12), (n=8), (n=8). Indirect (via sciatic nerve) (acupuncture needle piercing gastrocnemius) (stimuli starting from 0 V, cycle 3 s, increment 0.02 150 times) acted nerve muscle respectively. The electric intensity recorded experimental system BL-420F. data processed analyzed help...