A5031108204- Blood Pressure and Hypertension Studies
- Cancer, Lipids, and Metabolism
- Cardiovascular Health and Disease Prevention
- Gastric Cancer Management and Outcomes
- Hormonal Regulation and Hypertension
- Metabolism, Diabetes, and Cancer
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Retinoids in leukemia and cellular processes
- Renin-Angiotensin System Studies
- Cardiac Fibrosis and Remodeling
- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Eicosanoids and Hypertension Pharmacology
- Signaling Pathways in Disease
- Nuclear Receptors and Signaling
- Heart Rate Variability and Autonomic Control
- Atherosclerosis and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Peptidase Inhibition and Analysis
- Antioxidant Activity and Oxidative Stress
- Cerebrovascular and Carotid Artery Diseases
- Cancer-related molecular mechanisms research
- Receptor Mechanisms and Signaling
- Esophageal Cancer Research and Treatment
First Affiliated Hospital of Fujian Medical University
2016-2025
Fujian Medical University
2016-2025
Dongguan People’s Hospital
2024
Guangzhou University of Chinese Medicine
2023-2024
Guilin University of Technology
2023
Hypertension Institute
2014
Fujian Provincial Hospital
2009
American Red Cross
2005
Abstract Background Cardiac remodeling is one of the major risk factors for heart failure. In patients with type 2 diabetes, sodium–glucose cotransporter (SGLT2) inhibitors reduce first hospitalization failure, possibly through glucose-independent mechanisms in part, but underlying remain largely unknown. This study aimed to shed light on efficacy dapagliflozin reducing cardiac and potential mechanisms. Methods Sprague–Dawley (SD) rats, induced by chronic infusion Angiotensin II (Ang II) at...
Metabolic syndrome (MetS) has been shown to be associated with an increased risk of gastric cancer. However, the impact MetS on cancer mortality remains largely unknown. Here, we prospectively examined prediction preoperative for by analyzing a subset data from ongoing Fujian prospective investigation (FIESTA) study. This study was conducted among 3012 patients who received radical gastrectomy between 2000 and 2010. The latest follow-up completed in 2015. Blood/tissue specimens, demographic...
Sensitization to common foods is typically considered clinically irrelevant in individuals without symptomatic food allergies. However, recent studies found an association between IgE specific the mammalian oligosaccharide galactose-α-1,3-galactose and cardiovascular disease (CVD). The aims of this study are determine whether sensitization associated with early vascular aging (EVA) examine healthier lifestyle behaviors modifies CVD. This was a cross-sectional, population-based 2788 American...
Abstract Aims Effective therapeutic drugs for calcific aortic valve disease (CAVD) are lacking, although its incidence has been increasing over the past decade, and is predicted to continue rising in future. This study aimed explore role potential mechanisms of liver X receptor α (LXRα) CAVD, which offers a promising approach treating CAVD. Methods results Osteogenic stimulation was performed following substantial downregulation LXRα observed human valves valvular interstitial cells. Further...
This prospective study sought to investigate the prediction of preoperative metabolic syndrome and its components for risk colorectal cancer (CRC) mortality by analyzing a subset data from ongoing Fujian investigation (FIESTA) study. In total, 1,318 CRC patients who received radical resection were consecutively enrolled between January 2000 December 2008. The median follow‐up time was 58.6 months, with 412 deaths CRC. had significantly shorter survival (MST) than those without (50.9 vs ....
Abstract Nocturnal hypertension is highly prevalent among Chinese and Asian populations, which mainly attributed to high salt intake sensitivity. increases the risk of cardiovascular all‐cause mortality, independent daytime blood pressure (BP). However, it can usually be detected by 24‐h ambulatory BP monitoring, rather than routine office or home measurement, thus often underdiagnosed in clinical practice. Currently, no specific guidance available for management nocturnal China worldwide....
To assess the association between ultra-short heart rate variability (US-HRV) and short-term mortality in patients with COVID-19 develop prognostic prediction models to identify high-risk as early possible. A retrospective cohort study was performed on 488 diagnosed hospitalized First Affiliated Hospital of Fujian Medical University from December 2022 January 2023. 10-s electrocardiogram (ECG) data were available for these patients. The US-HRV parameters including standard deviation all...
Some metabolic factors have been shown to be associated with an increased risk of esophageal cancer; however the association its prognosis is rarely reported. Here, we assessed prediction preoperative syndrome and single components for cancer mortality by analyzing a subset data from ongoing Fujian prospective investigation (FIESTA) study. Between 2000 2010, patients who underwent three-field lymphadenectomy were eligible inclusion. Blood/tissue specimens, demographic clinicopathologic...
Background and aim . Upregulation of prolyl isomerase‐1 (Pin1) protein expression activity was associated with the pathogenesis diabetic vasculopathy through induction endothelial oxidative stress inflammation. Moreover, VDR agonist protects against high glucose‐induced apoptosis inhibition stress. We aimed to explore effects on diabetes‐associated dysfunction role Pin1 in this process. Methods Streptozocin‐induced mice were randomly treated vehicle, (10 μ g/kg/d, i.g., twice a week), or...
// Dan Hu 1, * , Feng Peng 2, Xiandong Lin Gang Chen 1 Binying Liang 3 Chao Li Hejun Zhang Xuehong Liao Jinxiu 2 Xiongwei Zheng Wenquan Niu 4 Department of Pathology, Fujian Provincial Cancer Hospital, The Affiliated Hospital Medical University, Fuzhou, Fujian, China Cardiology, First Medical-Record Department, State Key Laboratory Genomics, Rui Jin Shanghai Jiao Tong University School Medicine, Shanghai, Shared first authors Correspondence to: Peng, email: pengfeng@medmail.com.cn Zheng,...
Diabetes is a potential risk factor for gastric cancer (GC). Pin1, peptidyl-prolyl cis/trans isomerase, promotes GC cell proliferation and migration. The role underlying mechanism of the Pin1/BRD4 axis in hyperglycemia-induced migration cells were analyzed vivo vitro. Proliferation measured; Pin1 BRD4 expression cycle determined. downregulated by transfecting shRNA lentivirus into JQ1-intervention cells. Tumor formation lung metastasis assessed vivo. Inhibition significantly suppressed...
Retinoid X receptor (RXR) has been demonstrated to play an important role in cardiac development and implicated cardiovascular diseases. This study aimed examine the effects of RXRα agonist bexarotene on pathological left ventricular hypertrophy (LVH) a spontaneously hypertensive rat (SHR) model underlying mechanism. WKY rats served as controls. SHRs were randomized into 3 groups at age 4 weeks treated (once daily for 12 weeks) with either (30 or 100mg/kg body weight) vehicle alone....
This prospective study sought to evaluate the prediction of fasting blood glucose and long non-coding RNA (lncRNA) SNHG8 for risk gastric carcinoma mortality. A total 217 patients underwent radical gastrectomy were included during 2012-16. The final follow-up was finished in January 2017. aggregate hazard ratio(HR) demonstrated that poor prognosis associated with (HR= 1.29, P=0.037), expression(HR = 1.10, P= 0.009), positive distant metastasis(HR 2.99, 0.020), EBV (HR 3.40, P=0.002), tumor...
A phase 3 trial was conducted to evaluate the efficacy and safety of ongericimab, a monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9, as an add-on treatment optimized lipid-lowering therapy in Chinese patients with primary hypercholesterolemia mixed dyslipidemia.