A5101702530- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Scoliosis diagnosis and treatment
- Musculoskeletal pain and rehabilitation
- Regulation of Appetite and Obesity
- Pelvic and Acetabular Injuries
- Spinal Cord Injury Research
- Estrogen and related hormone effects
- Natural Compounds in Disease Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Pregnancy-related medical research
- Tuberculosis Research and Epidemiology
- Spinal Dysraphism and Malformations
- Osteoarthritis Treatment and Mechanisms
- Spinal Hematomas and Complications
- Growth Hormone and Insulin-like Growth Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Bone Metabolism and Diseases
- Fungal Biology and Applications
- Mycobacterium research and diagnosis
- Cell death mechanisms and regulation
- NF-κB Signaling Pathways
- Abdominal Surgery and Complications
Xian Yang Central Hospital
2024
Dalian University
2024
Dalian University of Technology
2024
Beijing Friendship Hospital
2024
Renji Hospital
2014-2023
Ruijin Hospital
2022-2023
Shanghai Jiao Tong University
2012-2023
Huazhong Agricultural University
2015-2022
Jiangmen Central Hospital
2019-2021
Indiana University School of Medicine
2019
The nonpathogenic bacterium Mycobacterium smegmatis mc2155 has been widely used as a model organism in mycobacterial research, yet detailed study about its transcription landscape remains to be established. Here we report the transcriptome, expression profiles and transcriptional structures through growth-phase-dependent RNA sequencing (RNA-seq) well other related experiments. We found: 1) 2139 start sites (TSSs) genome-wide scale, of which eight samples were randomly selected further...
Cyclic di-AMP (c-di-AMP) is a second signaling molecule involved in the regulation of bacterial physiological processes and interaction between pathogen host.However, regulatory network mediated by c-di-AMP Mycobacterium remains obscure.In M. smegmatis, diadenylate cyclase (DAC) was reported recently, but there still no investigation on phosphodiesterase (PDE).Here, we provide systematic study mechanism PDE smegmatis.Based our enzymatic analysis, MsPDE (MSMEG_2630), which contained DHH-DHHA1...
Objective . To investigate the effects of menopause on redox balance in intervertebral disc and to examine whether oxidative stress autophagy were associated with degeneration rats. Methods Thirty female Sprague‐Dawley rats randomly divided into three groups (sham, ovariectomized vehicle, estrogen). At end 3‐month treatment, examined by 3.0 T MRI. Serum estradiol (E2) level was measured. Redox nucleus pulposus determined measuring total antioxidant capacity (T‐AOC), superoxide dismutase...
Abstract Background The development of adjacent segment degeneration (ASD) following ACDF is well established. There no analytical study related to effects plate profile on the biomechanics adjacent-level after ACDF. This aimed test single-level anterior cervical discectomy and fusion (ACDF). Methods A three-dimensional finite element model (FEM) an intact C2–T1 was built validated. From this model, two instrumentation models were constructed with anchored zero-profile spacer or standard...
In Brief Study Design. A three-dimensional finite element investigation. Objectives. To create a model of the cervical spinal cord enlargement and to simulate hyperextension injury cord. Summary Background Data. Experimental studies are difficult complex mechanism injuries. The introduction modeling technique into neurotrauma is essential further understand mechanical behavior nerve tissue during traumatic Methods. Geometrical reconstruction was developed based on morphologic features each...
Objectives Cervical disc arthroplasty (CDA) with Discover prosthesis or anterior cervical discectomy and fusion (ACDF) Zero-P cage has been widely used in the treatment of spondylotic myelopathy (CSM). However, little is known about comparison 2 zero-profile implants single-level CSM. The aim was to compare clinical outcomes radiographic parameters CDA ACDF for Methods A total 128 consecutive patients who underwent 1-level CSM between September 2009 December 2012 were included this study....
Facet joint osteoarthritis is considered a consequence of the aging process; however, there evidence that it may be associated with degenerative changes other structures. The goal this study was to investigate correlation between lumbar multifidus muscle features and facet osteoarthritis. This retrospective included 160 patients who had acute or chronic low back pain were diagnosed on computed tomography scan. Morphometric parameters, including cross-sectional area, muscle-fat index,...
Abstract Purpose: The lack of effective treatment for pancreatic cancer results in a very low survival rate. This study explores the enhancement therapeutic effect on human via combination triptolide and ionizing radiation (IR). Experimental Design: In vitro AsPC-1 cells were treated with alone, IR or plus IR. Cell proliferation was analyzed sulforhodamine B (SRB) method clonogenic survival; comparison apoptosis induced by above annexin V–propidium iodide (PI) staining. Furthermore,...
The aim of this study was to compare the therapeutic effects anterior 'skip' corpectomy with posterior decompression for treating four-level cervical spondylotic myelopathy.Operation time and blood loss during operation approach groups were recorded. Patients examined lateral radiography before after measure Cobb's angle postoperatively monitor bony fusion. Surgery-, instrumentation-, graft-related complications assessed recorded.The surgical aspects both went smoothly, mean durations 2.5...
In Brief Study Design. Numerical techniques were used to study the mechanisms of acute central cord syndrome. Objective. To analyze features stress distribution in cervical under different injury conditions using finite element model and improve understanding possible pathogenesis Summary Background Data. Acute spinal was initially attributed hemorrhagic damage portion cord, but recent histopathologic studies showed that it predominantly a white matter injury. The precise anatomic location...
Purpose: Although degenerative lumbar spinal stenosis (LSS) is increasingly being diagnosed in older people, there much uncertainty about the appropriate operative treatment options. The objective of this study was to compare outcome percutaneous endoscopic decompression (PELD) versus fenestration for lateral recess (LRS) geriatric patients over 75 years old. Materials and methods: This prospective controlled performed on 46 consecutive aged with who underwent either PELD or fenestration....