A5100758344- Cervical and Thoracic Myelopathy
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Medical Imaging and Analysis
- Spinal Hematomas and Complications
- Pelvic and Acetabular Injuries
- Musculoskeletal pain and rehabilitation
- Management of metastatic bone disease
- Nerve Injury and Rehabilitation
- Bone Metabolism and Diseases
- Bone Tumor Diagnosis and Treatments
- Osteoarthritis Treatment and Mechanisms
- Shoulder Injury and Treatment
- Trauma Management and Diagnosis
- Hip and Femur Fractures
- Spinal Cord Injury Research
- Pain Mechanisms and Treatments
- Anesthesia and Pain Management
- Infectious Diseases and Tuberculosis
- Bone fractures and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Bone and Joint Diseases
- TGF-β signaling in diseases
- Foot and Ankle Surgery
- Dysphagia Assessment and Management
Shanghai Changzheng Hospital
2006-2024
Naval University of Engineering
2023
Second Military Medical University
2012-2021
National Natural Science Foundation of China
2020
The Affiliated Yongchuan Hospital of Chongqing Medical University
2018
Chongqing Medical University
2018
Military University
2012
Abstract Following peripheral nerve injury (PNI) microglia proliferates and adopts inflammation that contributes to development maintenance of neuropathic pain. miRNAs autophagy are two important factors in the regulation inflammation. However, little is known about whether regulate neuroinflammation pain by controlling autophagy. In study, we demonstrated miR‐195 levels were markedly increased rats subjected L5 spinal ligation (SNL). Upregulated was also found with SNL. The overexpression...
A retrospective clinical study was conducted.To compare surgical outcome of anterior approach (corpectomy and fusion) with that posterior (laminoplasty or laminectomy instrumented for the treatment multilevel severe ossification longitudinal ligament (OPLL) in cervical spine, simultaneously to investigate potential benefits fusion after by comparing it laminoplasty.Surgical strategy OPLL spine still remains controversial. Although advantages decompression have been reported earlier, becomes...
Long non-coding RNAs (lncRNAs) are known players in the regulatory circuitry of self-renewal human embryonic stem cells (hESCs). However, most hESC-specific lncRNAs remain uncharacterized. Here we demonstrate that growth-arrest-specific transcript 5 (GAS5), a tumour suppressor and growth arrest-related lncRNA, is highly expressed directly regulated by pluripotency factors OCT4 SOX2 hESCs. Phenotypic analysis shows GAS5 knockdown significantly impairs hESC self-renewal, but its overexpression...
The precise role of apoptosis in the pathogenesis intervertebral disc degeneration (IDD) remains to be elucidated. We analyzed degenerative nucleus pulposus (NP) cells and found that expression miR-27a was increased. overexpression further verified using real-time RT-PCR. Bioinformatics target prediction identified phosphoinositide-3 kinases (PI3K) as putative targets miR-27a. Furthermore, inhibited PI3K by directly targeting their 3'-UTRs, this inhibition abolished mutation binding sites....
The purpose of this study was to compare modified plate-only laminoplasty and laminectomy fusion confirm which the 2 surgical modalities could achieve a better decompression outcome whether significant difference found in postoperative complications. Clinical data were retrospectively reviewed for 141 patients with cervical stenotic myelopathy who underwent between November 2007 June 2010. extent assessed by measuring cross-sectional area dural sac distance spinal cord drift at 3 most...
Abstract Objectives Apoptosis of nucleus pulposus ( NP ) cells is a major cause intervertebral disc degeneration. To elucidate relationships between caveolin‐1 and cytokine‐induced apoptosis, we investigated the role in apoptosis rat related signalling pathway. Materials methods Rat were treated with interleukin IL )‐1β or tumour necrosis factor alpha TNF ‐α), knockdown β‐catenin was achieved using specific si RNA s. Then, apoptotic level expression activation caveolin‐1/β‐catenin assessed...
Although anterior and posterior decompression surgery are both reported to treat patients with myelopathy caused by ossification of the longitudinal ligament (OPLL). The surgical strategy disease is still controversial when OPLL multilevel severe. This present study reports preliminary clinical results a novel technique named controllable antidisplacement fusion (ACAF) for treatment multilevel-severe myelopathy. A series 15 cervical compression severe were enrolled. All underwent ACAF after...
The conventional treatment for displaced intraarticular fractures of the calcaneus (DIACF), with open reduction and internal plate fixation (ORIF), carries risk wound infection delayed recovery. Alternatively percutaneous techniques offer possibility equivalent outcomes in a soft tissue complications. goal present study was to evaluate outcome (PR), screw fixation, calcium sulphate cement (CSC) grafting DIACF.Ninety patients were randomly assigned PR CSC or ORIF between January 2006 August...
In a retrospective cohort study we compared the clinical outcome and complications, including dysphagia, following anterior cervical fusion for treatment of spondylosis using either zero-profile (Zero-P; Synthes) implant or an plate cage. A total 83 patients underwent Zero-P 107 The mean follow-up was 18.6 months (SD 4.2) in group 19.3 4.1) cage group. All both groups had significant symptomatic neurological improvement. There were no differences between Neck Disability Index (NDI) visual...
Prolyl-4-hydroxylase (PHD) proteins are key in sensing tissue hypoxia. In nucleus pulposus (NP) cells, our previous work demonstrated that PHD isoforms have a differential contribution controlling hypoxia-inducible factor (HIF)-α degradation and activity. Recently we shown regulatory relationship exists between PHD3 inflammatory cytokines NP cells. With respect to PHD2, the most abundant isoform very little is known concerning its function regulation under conditions characterize...
Objectives Cervical disc arthroplasty (CDA) with Discover prosthesis or anterior cervical discectomy and fusion (ACDF) Zero-P cage has been widely used in the treatment of spondylotic myelopathy (CSM). However, little is known about comparison 2 zero-profile implants single-level CSM. The aim was to compare clinical outcomes radiographic parameters CDA ACDF for Methods A total 128 consecutive patients who underwent 1-level CSM between September 2009 December 2012 were included this study....
Objectives: Ossification of the posterior longitudinal ligament (OPLL) presents as development heterotopic ossification in spine. The etiology OPLL is genetically linked, shown by its high prevalence Asian populations. However, molecular mechanism disease remains obscure. In this study, we explored function and OPLL-specific microRNAs. Methods: expression levels ossification-related miR-181 family were measured normal or tissues. effect miR-181a on pathogenic cells was tested using real-time...
Ossification of the posterior longitudinal ligament is a common cause cervical myelopathy, and controversy remains regarding surgical options. Between January 2004 December 2007, total 164 patients with ossification in spine who underwent treatment at authors’ institution were included this study. The choice option was based on pathological extent alignment. Short-segment pathology treated via anterior approach long-segment approach. When selected, laminoplasty performed for lordosis...
Discogenic low back pain (DLBP) is extremely common and costly. Effective treatments are lacking due to DLBP's unknown pathogenesis. Currently, there no in vivo mouse models of DLBP, which restricts research this field. The aim study was establish a reliable DLBP model that captures the pathological changes disc allows longitudinal testing. generated by puncturing lumbar discs (L4/5, L5/6, L6/S1) removing nucleus pulposus using microscalpel under microscope. Histology, molecular pathways,...
Abstract Intervertebral disc degeneration (IDD) is characterized by disordered extracellular matrix (ECM) metabolism, implicating subdued anabolism and enhanced catabolic activities in the nucleus pulposus (NP) of discs. Pro-inflammatory cytokines such as interleukin-1β (IL-1β) are considered to be potent mediators ECM breakdown. Hemeoxygenase-1 (HO-1) has been reported participate cellular anti-inflammatory processes. The purpose this study was investigate HO-1 modulation metabolism human...
Study Design. A retrospective study. Objective. To assess the long-term results of zero-profile spacer for 3-level anterior cervical discectomy and fusion (ACDF). Summary Background Data. Although widely used, there are still controversies about spacer, especially in multilevel cases. Methods. Cases received ACDF spondylotic myelopathy (CSM) using either (n = 27) (ZP Group), or plate cages 34) (PC with 5-year follow-up were reviewed. Neurological function life quality assessed by modified...
ABSTRACT The enzyme chondroitin polymerizing factor (ChPF) is primarily involved in extension of the sulfate backbone required for synthesis sulfated glycosaminoglycan (sGAG). Transforming growth beta (TGF‐β) upregulates sGAG nucleus pulposus cells; however, mechanisms mediating this induction are incompletely understood. Our study demonstrated that ChPF expression was negatively correlated with grade degenerative intervertebral disc disease. Treatment cells TGF‐β induced and enhanced...
// Bo Hu 1, * , Chen Xu Ye Tian Changgui Shi 1 Ying Zhang Lianfu Deng 2 Hongyu Zhou Peng Cao Huajiang and Wen Yuan Department of Spine Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China Shanghai Key Laboratory for Bone Joint Diseases, Institute Orthopaedics Traumatology, Ruijin Jiao Tong University School Medicine, These authors contributed equally to this work Correspondence to: Chen, email: spine.chen@163.com Yuan, yuanwenspine@126.com Cao,...