A5101806298- Acute Ischemic Stroke Management
- Glaucoma and retinal disorders
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- SARS-CoV-2 and COVID-19 Research
- Parkinson's Disease Mechanisms and Treatments
- Animal Virus Infections Studies
- Ocular Surface and Contact Lens
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- Aquaculture Nutrition and Growth
- Hepatocellular Carcinoma Treatment and Prognosis
- Corneal surgery and disorders
- CAR-T cell therapy research
- 2D Materials and Applications
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Animal Disease Management and Epidemiology
- Intracerebral and Subarachnoid Hemorrhage Research
- Aquaculture disease management and microbiota
- Liver Disease Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Retinal Diseases and Treatments
- Epigenetics and DNA Methylation
Tongji University
2012-2025
Central South University
2019-2025
First Affiliated Hospital Zhejiang University
2023-2025
Shanghai Tenth People's Hospital
2017-2025
He Eye Hospital
2022-2025
University of Shanghai for Science and Technology
2025
Hunan Children's Hospital
2025
University of South China
2025
Beijing Forestry University
2025
Capital Medical University
2024
BACKGROUND: Whether it is effective and safe to extend the time window of intravenous thrombolysis up 24 hours after last known well unknown. We aimed determine efficacy safety tenecteplase in Chinese patients with acute ischemic stroke due large/medium vessel occlusion within an extended window. METHODS: Patients presenting 4.5 from well, a favorable penumbral profile associated occlusion, were randomized 1:1 either 0.25 mg/kg or best medical treatment. A was defined as hypoperfusion lesion...
Abstract The extensive industrial applications of fuel oil, a critical strategic resource, are accompanied by significant environmental and health concerns due to the presence sulfur‐containing compounds in its composition, which result hazardous combustion waste. Extensive research has been conducted develop technologies for low‐vulcanization production address this issue. Consequently, investigation catalysts environmentally friendly safe photocatalytic desulfurization becomes imperative....
Androgen deprivation therapy in prostate cancer (PCa) causes neuroendocrine differentiation (NED) of prostatic adenocarcinomas (PAC) cells, leading to recurrence PCa. Androgen-responsive genes involved PCa progression including NED remain largely unknown. Here we demonstrated the importance androgen receptor (AR)-microRNA-204 (miR-204)-XRN1 axis cell lines and rat ventral prostate. Androgens downregulate miR-204, resulting induction XRN1 (5'-3' exoribonuclease 1), which identified as a...
Background The performance of intravenous tenecteplase in patients who had an acute ischaemic stroke with large/medium vessel occlusion or severe stenosis extended time window remains unknown. We investigated the promise efficacy and safety different doses manufactured China, beyond 4.5-hour window. Methods CHinese Acute tissue-Based imaging selection for Lysis In Stroke-Tenecteplase was investigator-initiated, umbrella phase IIa, open-label, blinded-endpoint, Simon’s two-stage randomised...
Plant disease detection remains a significant challenge, necessitating innovative approaches to enhance efficiency and accuracy. This study proposes an improved YOLOv8 model, SerpensGate-YOLOv8, specifically designed for plant tasks. Key enhancements include the incorporation of Dynamic Snake Convolution (DySnakeConv) into C2F module, which improves intricate features in complex structures, integration SPPELAN combining Spatial Pyramid Pooling (SPP) Efficient Local Aggregation Network (ELAN)...
<title>Abstract</title> <bold>Background</bold> Recent studies have found that ferroptosis may be involved in the process of trabecular meshwork injury glaucoma. This study aims to reveal ferroptosis-related gene signature primary open-angle glaucoma (POAG) and identify small molecule drugs as new direction therapy. <bold>Methods</bold> Ferroptosis-related indicators POAG patients chronic ocular hypertension (COH) rats were detected by ELISA kits. The dataset (GSE27276) from GEO database...
The aim of this study was to investigate the early effectiveness guided growth techniques for managing congenital anterolateral bowing tibia (ALBT) in children. A retrospective analysis performed involving 18 patients with ALBT treated ‘U’-shaped staple-guided technique between January 2020 and October 2022 at two centres. Anteroposterior lateral radiographs both lower limbs as well fibula were collected before surgery, time implant removal, or last follow-up. Changes coronal tibial...
Objective: Eosinophilic esophagitis (EoE), an allergen/immune-mediated chronic disorder of the esophagus, is witnessing incremental rise in its global incidence. However, data China are very limited. This study aimed to clarify characteristics EoE Chinese adults at our medical center. Methods: We collected information, including clinical and endoscopic findings, relative all cases adult patients who met pathological diagnostic criteria for institution from January 2019 May 2024. Patients...
Aims This research aims to establish a chromatin regulator (CR) signature provide new epigenetic insights into the pathogenesis of primary open-angle glaucoma (POAG).
The purpose of this study was to interrogate the potential role N6-methyladenosine (m6A) regulators in process trabecular meshwork (TM) tissue damage patients with primary open-angle glaucoma (POAG). Firstly, expression profile m6A TM tissues POAG comprehensively analyzed by bioinformatics analysis; Plasmid transfection and siRNA gene interference were used enhance or weaken levels YTHDC2 human cells (HTMCs); Cell migration ability detected transwell chamber assay; Immunofluorescence...
Dipeptidyl peptidase 9 (DPP9) is encoded by DPP9, which belongs to the DPP4 gene family. Proteins these genes have unique and extra-enzymatic functions that been linked various diseases including cancers. Here, we describe expression pattern biological function of DPP9 in non-small-cell lung cancer (NSCLC). The repression small interfering RNA inhibited cell proliferation, migration, invasion. Moreover, explored role regulating epithelial-mesenchymal transition (EMT). epithelial markers...
Bisphenol A (BPA), an exogenous endocrine-disrupting chemical, has been shown to alter DNA methylation. However, little information is available about the effect of BPA exposure on hydroxymethylation in humans. The objective present study was examine whether associated with human semen samples. We measured urine levels and LINE-1 158 male factory workers selected from occupational cohort conducted China between 2004 2008. Among them, there were 72 (BPA-exposed group) 86 without (unexposed...
In this study, we aimed to evaluate the safety and efficiency of low dose intra- arterial tirofiban in mechanical thrombectomy acute ischemic stroke patients facilitate reperfusion distal vessel.We retrospectively analyzed 54 consecutive who underwent for large-vessel occlusion. Patients were divided into two groups based on whether intra-arterial was used during vessel. Non-tirofiban group (n=28) have received thrombectomy, while Tirofiban (n=26) with a tirofiban. We comparatively bleeding...
Mechanical thrombectomy (MT) is effective in managing patients with acute ischemic stroke (AIS) caused by large-vessel occlusions and allows for valuable histological analysis of thrombi. However, whether bridging therapy (pretreatment intravenous thrombolysis before MT) provides additional benefits middle cerebral artery (MCA) occlusion remains unclear. Therefore, this study aimed to compare the effects direct MT therapy, elucidate correlation between thrombus composition subtypes....
Personalized prediction of the risk symptomatic intracerebral hemorrhage (sICH) after stroke thrombolysis is clinically useful. Machine-learning-based modeling may provide personalized sICH thrombolysis.We identified 2578 thrombolysis-treated ischemic patients between January 2013 and December 2016 from a multicenter database, where 70% were used to train models remaining 30% as nominal test sets. Another 136 consecutive tissue plasminogen-activated-treated 2017 our institute enrolled...
Although COVID-19 vaccines have been developed, multiple pathogenic coronavirus species exist, urging on development of multispecies vaccines. Here we develop prototype lipid nanoparticle (LNP)-mRNA vaccine candidates against SARS-CoV-2 Delta, SARS-CoV, and MERS-CoV, test how multiplexing LNP-mRNAs can induce effective immune responses in animal models. Triplex duplex LNP-mRNA vaccinations antigen-specific antibody SARS-CoV-2, MERS-CoV. Single-cell RNA sequencing profiles the global systemic...
H10 subtype avian influenza viruses (AIVs) have been isolated from wild and domestic species worldwide occasionally crossed the barrier to mammalian hosts. Fatal human cases of H10N8 infections recent detection H10N3 drawn widespread public attention. In this study, 25 H10Nx were waterfowl in China during a long-term surveillance AIVs. We conducted phylogenetic phylogeographic studies hemagglutinin (HA) genes global determine spatiotemporal patterns spread roles different hosts viral...