A5051131236- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Cardiovascular Disease and Adiposity
- Long-Term Effects of COVID-19
- Immune cells in cancer
- Cardiovascular Health and Disease Prevention
- Folate and B Vitamins Research
- Venous Thromboembolism Diagnosis and Management
- COVID-19 Clinical Research Studies
- Acute Ischemic Stroke Management
- Amyotrophic Lateral Sclerosis Research
- Calpain Protease Function and Regulation
- RNA regulation and disease
- Sirtuins and Resveratrol in Medicine
- Blood Coagulation and Thrombosis Mechanisms
- Infectious Encephalopathies and Encephalitis
- Cerebrovascular and Carotid Artery Diseases
- Adipokines, Inflammation, and Metabolic Diseases
Shanghai Tenth People's Hospital
2018-2022
Tongji University
2018-2022
Shanghai Second People's Hospital
2021
In this study, we aimed to evaluate the safety and efficiency of low dose intra- arterial tirofiban in mechanical thrombectomy acute ischemic stroke patients facilitate reperfusion distal vessel.We retrospectively analyzed 54 consecutive who underwent for large-vessel occlusion. Patients were divided into two groups based on whether intra-arterial was used during vessel. Non-tirofiban group (n=28) have received thrombectomy, while Tirofiban (n=26) with a tirofiban. We comparatively bleeding...
Microglia activation contributes to Alzheimer’s disease (AD) etiology, and microglia migration is a fundamental function during activation. The repressor element-1 silencing transcription factor (REST), powerful transcriptional factor, was found play neuroprotective role in AD. Despite its possible progression, little known about whether REST participates migration. In this study, we aimed explore the of molecular basis under Aβ1-42-treated pathological conditions. When treated by Aβ1-42...
Background: The novel coronavirus disease 2019 (COVID-19) was broken out in December and soon became a global health emergency. Effective treatment for COVID-19 is urgently needed. In the present study, we aimed to evaluate antiviral effect of Arbidol vs. Chloroquine treating COVID-19.Methods: We retrospectively analyzed 62 patients with diagnosed according guidelines diagnosis China. They were divided into two groups depending on drugs that they received. Participants group (n=42) received...
Background Abdominal obesity and adipocytokines are closely related to atherosclerosis, adiponectin level is considered one of the important clinical indicators. This study aimed analyze associations abdominal visceral fat content with intracranial atherosclerotic stenosis (ICAS). Methods A total 186 patients were enrolled in this study. Patients distributed into ICAS non-ICAS by degree artery stenosis. Plasma levels ratio adipose tissue (VAT) subcutaneous (SAT) measured. The factors...
Abstract Cognitive dysfunction is one of the complications diabetes. Unfortunately, there no effective methods to block its progression currently. One pathophysiological mechanisms synaptic protein damage and neuronal signal disruption because glucose metabolism disorder. Dystroglycan protein, located in post‐synaptic membrane neurons, links intracellular cytoskeleton with extracellular matrix. Abnormal expression dystroglycan affects biological functions leads cognitive impairment. However,...
In the present study, 126 patients, 90 cases in WML group and 36 control group, were analyzed to explore relationship between adiponectin WMLs. All patients underwent an MRI scan assess whether white matter lesions happened. And serum levels of detected by ELISA.In this according Fazekas criteria, WMLs divided into different severity groups. With increase score, level decreased, linear correlation analysis shows that is negatively correlated with (p < 0.001). was significantly positively...
Compelling evidence from basic molecular biology has demonstrated the crucial role of microglia in pathogenesis Alzheimer's disease (AD). Microglia were believed to play a dual both promoting and inhibiting progression. It is great significance regulate function make them develop favorable way. In present study, we investigated repressor element 1-silencing transcription factor (REST) Aβ 1-42-induced BV-2 cell dysfunction. We concluded that 1-42 could promote type I activation cells induce...