A5026755847- Cerebrovascular and Carotid Artery Diseases
- Extracellular vesicles in disease
- Neurogenesis and neuroplasticity mechanisms
- Acute Ischemic Stroke Management
- Neurological Disease Mechanisms and Treatments
- Glioma Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Barrier Structure and Function Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Cardiovascular Health and Disease Prevention
- Brain Metastases and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Pharmacological Receptor Mechanisms and Effects
- Antiplatelet Therapy and Cardiovascular Diseases
- Retinal and Optic Conditions
- Folate and B Vitamins Research
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Epilepsy research and treatment
- interferon and immune responses
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular and Diving-Related Complications
- Sirtuins and Resveratrol in Medicine
- Signaling Pathways in Disease
Tongji University
2014-2025
Shanghai Tenth People's Hospital
2014-2024
Abstract The relationship between marital status and glioblastoma multiforme ( GBM ) has not been addressed in depth. Here, we aimed to investigate the association survival . We searched Surveillance, Epidemiology, End Results SEER database extracted data of eligible patients diagnosed with after 2004. Marital was classified as married, divorced/separated, widowed, single. A Kaplan‐Meier test conducted compare curves different groups. Multivariate Cox regression performed evaluate overall OS...
Abstract The ratio of excitatory to inhibitory neurotransmitters is essential for maintaining the firing patterns neural networks, and strictly regulated within individual neurons brain regions. Excitatory (E/I) imbalance has been shown participate in progression neurodegenerative diseases, including Alzheimer's disease (AD). Glutamate excitotoxicity GABAergic neuron dysfunction appear be key components neuronal cell death that takes place AD. Since extracellular vesicles (EVs) are now...
Background Abdominal obesity and adipocytokines are closely related to atherosclerosis, adiponectin level is considered one of the important clinical indicators. This study aimed analyze associations abdominal visceral fat content with intracranial atherosclerotic stenosis (ICAS). Methods A total 186 patients were enrolled in this study. Patients distributed into ICAS non-ICAS by degree artery stenosis. Plasma levels ratio adipose tissue (VAT) subcutaneous (SAT) measured. The factors...
Objectives Moderate-to-severe sleep-disordered breathing (SDB) is prevalent in patients with acute ischaemic stroke (AIS) and associated an increased risk of unfavourable prognosis. We aimed to develop validate a reliable scoring system for the early screening moderate-to-severe SDB AIS, objective improving management those at risk. Study design developed validated nomogram model based on univariate multivariate logistic analyses identify AIS patients. was defined as apnoea-hypopnoea index...
Abstract INTRODUCTION Vascular cognitive impairment (VCI) is highly heterogeneous, with unclear pathogenesis. Individuals vascular risk factors (VRF), cerebral small vessel disease (CSVD), and stroke are all at of developing VCI. To address the growing challenges posed by VCI, “Vascular, Imaging Cognition Association China” (VICA) was established. METHODS VICA aims to recruit 10,000 participants, including 2000 VRF, 3000 CSVD, 5000 patients, form a nationwide multicenter cohort. The study...
In the present study, 126 patients, 90 cases in WML group and 36 control group, were analyzed to explore relationship between adiponectin WMLs. All patients underwent an MRI scan assess whether white matter lesions happened. And serum levels of detected by ELISA.In this according Fazekas criteria, WMLs divided into different severity groups. With increase score, level decreased, linear correlation analysis shows that is negatively correlated with (p < 0.001). was significantly positively...
Acute ischemic stroke is caused by stenosis of artery supplying to brain. We aimed detect some metabolites in the serum that would be related degree and analyze potential mechanisms.Patients diagnosed with acute were divided into two groups according their (which was determined computed tomographic angiography): a mild group (stenosis ≤ 30%) severe > 30%). Serum from these patients collected, we focused on differences concentrations calcium, uric acid, low density lipoprotein homocysteine....
Abstract Background: Diabetes is a metabolic disease that has been widely demonstrated to be correlated with many microvascular and macrovascular diseases seriously damage the patient’s life quality. This study intended investigate underlying molecular mechanisms of endothelial dysfunction under hyperglycemia. Methods: The gene expression profile GSE49524 was downloaded differentially expressed genes (DEGs) in hyperglycemia human umbilical cord cells (HUVECs) samples compared normoglycemia...