A5034921533- Acute Ischemic Stroke Management
- Neuroscience and Neuropharmacology Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Attention Deficit Hyperactivity Disorder
- Retinoids in leukemia and cellular processes
- Neurological Disease Mechanisms and Treatments
- Gut microbiota and health
- High Altitude and Hypoxia
- Stroke Rehabilitation and Recovery
- Neurological Disorders and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Cervical Cancer and HPV Research
- Heme Oxygenase-1 and Carbon Monoxide
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Antioxidant Activity and Oxidative Stress
- Adenosine and Purinergic Signaling
- Cerebrospinal fluid and hydrocephalus
- Inflammatory Biomarkers in Disease Prognosis
- Myasthenia Gravis and Thymoma
- Intracranial Aneurysms: Treatment and Complications
- Cancer, Hypoxia, and Metabolism
- Venous Thromboembolism Diagnosis and Management
Chengdu University of Technology
2025
Ministry of Ecology and Environment
2025
Tongren Hospital
2024
Shanghai Jiao Tong University
2024
Shanghai Tenth People's Hospital
2015-2024
Tongji University
2015-2024
Xiangya Hospital Central South University
2023
Central South University
2023
South China Agricultural University
2022
Tang Du Hospital
2021
Background: Post-stroke cognitive impairment (PSCI) is an important factor causing disabilities after acute ischemic stroke (AIS). Emerging evidence suggested that gut microbiota play role in impairment. Objective: This study aimed to explore the association between PSCI and microbiota. Method: 65 patients with newly diagnostic AIS finished fecal collection on admission assessment 3 months later clinic. Fecal samples were subjected 16SrRNA gene sequencing gas chromatography-mass spectrometry...
Higher plasma urate level is reported to be associated with a reduced risk and slower progression of Parkinson's disease (PD). In this study, we explored the effects on dopaminergic neurons in nigrostriatal pathway 6-hydroxydopamine (6-OHDA) unilaterally lesioned rats. Uric acid (UA), when given twice daily at 200 mg/kg intraperitoneally for 10 consecutive days, elevated (the anionic form UA) striatum by 55% 36.8%, respectively, as compared vehicle group. This regimen UA was found ameliorate...
Chronic urticaria (CU) is defined as the continuous or intermittent presence of for a period exceeding 6 weeks and sometimes occurring with angioedema. Between 66% 93% patients CU have chronic spontaneous (CSU), precise pathogenesis which largely unknown. The aim this study was to determine relationship between gut microbiota serum metabolites possible underlying CSU. We collected feces blood samples from CSU healthy controls assessed using 16S rRNA gene sequencing untargeted metabolomic...
Dopamine produces a time- and dose-dependent increase in cell death clonal catecholaminergic line (CATH.a) derived from the central nervous system. Cell also occurred after treatment with catecholamines L-dihydroxyphenylalanine, norepinephrine, epinephrine, isoproterenol, as well neurotoxic compound 6-hydroxydopamine. is not receptor mediated because selective noradrenergic dopaminergic agonists had no effect on CATH.a viability. induces apoptotic indicated by DNA fragmentation measured gel...
This study investigated the effect of berberine (BBR) on growth performance and composition function cecal microbiota in yellow-feathered broilers. A total 360 1-day-old female broilers were assigned to 3 dietary treatments, each with 6 replicates 20 birds. The treatments consisted a basal diet as negative control (NC), plus 200 mg/kg oxytetracycline calcium 250 nasiheptide an antibiotic positive (PC), BBR. On day 21, 42, 63, one chicken from replicate was randomly selected for blood...
To study possible interactions between dopamine (DA) and serotonin (5-HT) neurochemical systems in the D-1 supersensitized induction of oral activity neonatal 6-hydroxydopamine (6-OHDA) lesioned rats, effects a series 5-HT agonists antagonists were determined. At 3 days after birth rats treated with desipramine HCl (20 mg/kg i.p., base form, 1 hr) 6-OHDA HBr (100 micrograms, salt each lateral ventricle). Rats observed individually as adults, once minute every 10 min over 1-hr period...
The aim of this study is to investigate the dysbiosis characteristics gut microbiota in patients with cerebral infarction (CI) and its clinical implications.Stool samples were collected from 79 CI 98 healthy controls subjected 16S rRNA sequencing identify stool microbes. Altered compositions functions correlation features investigated. Random forest receiver operating characteristic analysis used develop a diagnostic model.Microbiota diversity structure between overall similar. However,...
Background: Poststroke cognitive impairment (PSCI) has been increasingly recognized in patients, but some stroke survivors appear to show improvement beyond the acute stage. The risk factors associated with recovery after spontaneous intracerebral hemorrhage (ICH) onset have not yet sufficiently investigated prospective studies. Objective: We aimed identify trajectory of post-ICH and association potential prognostic follow-up early PSCI. Methods: In this center-based cohort study, 141...
Introduction: This multicenter, retrospective study assessed the prevalence of post-stroke cognitive impairment (PSCI) 6 months after acute ischemic stroke (AIS) and its risk factors to build a bedside early predictive model for PSCI using Montreal Cognitive Assessment (MoCA). Methods: Records consecutive patients with AIS treated at 4 centers in Shanghai had MoCA assessments within 2 weeks onset later were reviewed. Prevalence (MoCA<22) was calculated identified by multivariate logistic...
Mechanical thrombectomy (MT) is effective in managing patients with acute ischemic stroke (AIS) caused by large-vessel occlusions and allows for valuable histological analysis of thrombi. However, whether bridging therapy (pretreatment intravenous thrombolysis before MT) provides additional benefits middle cerebral artery (MCA) occlusion remains unclear. Therefore, this study aimed to compare the effects direct MT therapy, elucidate correlation between thrombus composition subtypes....
Abstract: To study potential biochemical correlates of dopamine (DA) and serotonin receptor supersensitivity, rats were lesioned at 3 days after birth with 6‐hydroxydopamine (6‐OHDA; 67 µg in each lateral ventricle; desipramine pretreatment, 20 mg/kg i.p., 1 h) then sensitized the DA D agonist, SKF 38393 HCl (3.0 i.p. per day) either ontogenetically (daily, for 28 consecutive from birth) and/or adulthood (four weekly injections, 6–9 weeks birth). Controls received vehicle place 6‐OHDA or...
An easily scoring system to predict the risk of cognitive impairment after minor ischemic stroke has not been available. We aimed develop and externally validate a nomogram for predicting probability post-stroke (PSCI) among hospitalized population with stroke. Moreover, association Trimethylamine N-oxide (TMAO) PSCI is also investigated. prospectively conducted developed cohort on collected data in center from June 2017 February 2018, as well an external validation between 2018 2019. The...
Background The subarachnoid space is continuous with the perivascular compartment in central nervous system. However, whether topography and severity of enlarged spaces (EPVS) correlates spontaneous hemorrhage (SAH) remains unknown. Based on underlying arteriopathy distributions, we hypothesized that EPVS basal ganglia (BG-EPVS) are more closely associated aneurysmal (aSAH) than other SAH without aneurysm. Methods Magnetic resonance imaging (MRI) scans 271 consecutive survivors aneurysm were...
As a putative marker of cerebral small vessel disease, microbleeds (CMBs) have been associated with vascular cognitive impairment. Both iron accumulation and amyloid protein precursor (APP) dysregulation are recognized as pathological hallmarks underlying the progression CMBs, but their cross-talk is not yet understood. In this study, we found profound increase formation increasing FeCl 3 treatment, distinct change in APP metabolism expression homeostasis proteins (ferritin, Fpn1, regulatory...
Intracranial Atherosclerotic Stenosis (ICAS) is an important risk factor for cognitive impairment. However, it unclear whether patients with ICAS are more likely to develop impairment after acute, non-disabling ischemic stroke (minor stroke).We aimed investigate the association between and post-stroke impairment.In this cross-sectional study, underwent two tests imaging evaluation ICAS, within weeks stroke. To determine impairment, we performed a multivariate logistic regression analysis...
A part of the axonal cytoskeleton protein complex, neurofilament light chain (NF-L) has been suggested as a pathological hallmark in various neurological disorders, including hemorrhagic stroke, vascular dementia, and cerebral small vessel disease. Neuroaxonal debris are mainly engulfed phagocytosed by microglia, while effects NF-L on microglia have not elucidated. Ferritin heavy (FTH) only reflects age-related status but may also be secreted into extracellular space. After treatment with...