A5101672355- Acute Ischemic Stroke Management
- earthquake and tectonic studies
- Congenital gastrointestinal and neural anomalies
- Inflammatory Bowel Disease
- GNSS positioning and interference
- High-pressure geophysics and materials
- S100 Proteins and Annexins
- Geology and Paleoclimatology Research
- Landslides and related hazards
- Earthquake Detection and Analysis
- Groundwater flow and contamination studies
- Groundwater and Isotope Geochemistry
- Gastrointestinal disorders and treatments
- Medical Research and Treatments
- Antimicrobial Resistance in Staphylococcus
- Bone Tissue Engineering Materials
- Copper-based nanomaterials and applications
- Hydrology and Watershed Management Studies
- Geological Modeling and Analysis
- Geophysics and Gravity Measurements
- Bacterial Identification and Susceptibility Testing
- Ferroptosis and cancer prognosis
- Advanced Photocatalysis Techniques
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
Children's Hospital of Fudan University
2019-2025
Lanzhou University
2024
Qingdao University
2015-2024
Shanghai Jiao Tong University
2015-2022
National Clinical Research Center for Digestive Diseases
2022
Shanghai Ninth People's Hospital
2005-2022
Guilin Medical University
2022
Nanjing University
2016-2021
Shanghai Sixth People's Hospital
2015-2021
Huashan Hospital
2021
Kaempferol has been shown to protect cells against cerebral ischemia/reperfusion injury through inhibition of apoptosis. In the present study, we sought investigate whether ferroptosis is involved in oxygen-glucose deprivation/reperfusion (OGD/R)-induced neuronal and effects kaempferol on OGD/R-treated neurons. Western blot, immunofluorescence, transmission electron microscopy were used analyze ferroptosis, whereas cell death was detected using lactate dehydrogenase (LDH) release. We found...
Abstract To better understand the effects of scaffold materials for bone morphogenetic protein 2 (BMP‐2) genetic tissue engineering in vivo , several gels, including alginate, collagen, agarose, hyaluronate, fibrin, or Pluronic, were mixed with adenovirus‐mediated human BMP‐2 gene (Adv‐hBMP‐2) transduced marrow stromal cells (BMSCs) and injected into muscles athymic mice to evaluate resulting osteogenesis chondrogenesis. These gel gene‐transduced BMSC mixtures also loaded onto β‐TCP/HAP...
Severe hypoglycemia induces brain edema by upregulating aquaporin-4 (AQP4) expression and degrading tight junctions. Acute severe a proinflammatory environment that may contribute to disruption in the epithelial barrier decreasing junction protein expression. Interestingly, altered AQP4 has been considered play critical role neuroinflammation during acute injury. It shown deletion reduces inflammation AQP4-null mice after intracerebral LPS injection. However, effect of regarding protection...
Introduction: This multicenter, retrospective study assessed the prevalence of post-stroke cognitive impairment (PSCI) 6 months after acute ischemic stroke (AIS) and its risk factors to build a bedside early predictive model for PSCI using Montreal Cognitive Assessment (MoCA). Methods: Records consecutive patients with AIS treated at 4 centers in Shanghai had MoCA assessments within 2 weeks onset later were reviewed. Prevalence (MoCA<22) was calculated identified by multivariate logistic...
The aim of this study was to investigate the effects simvastatin on insulin secretion in mouse MIN6 cells and possible mechanism. were, respectively, treated with 0 μ M, 2 5 10 M for 48 h. Radio immunoassay performed measure effect cells. Luciferase method used examine content ATP Real-time PCR western blotting were mRNA protein levels inward rectifier potassium channel 6.2 (Kir6.2), voltage-dependent calcium 1.2<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mo...
Hypoxia is a risk factor for Alzheimer's disease (AD). Besides, mitochondrial fission increased in response to hypoxia. In this study, we sought investigate whether hypoxia-induced plays critical role regulating amyloid-β (Aβ) production. significantly activated extracellular signal-regulated kinase (ERK), phosphorylation of dynamin-related protein 1 (Drp1) at serine 616, and decreased Drp1 637. Importantly, hypoxia triggered dysfunction, elevated β-secretase (BACE1) γ-secretase activities,...
Abstract Background ADAMTS13 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13) plays vital role in preventing microvascular thrombosis inflammation. Reduced levels plasma have been detected multiple sclerosis (MS) patients. In the present study, we determined of disease progression MS using mouse model experimental autoimmune encephalomyelitis (EAE). Methods Female C57BL/6 mice were immunized MOG 35–55 peptide then treated or vehicle preventive therapeutic...
Specialized pro-resolving mediators (SPMs) are bioactive lipids derived from n-3 and n-6 polyunsaturated fatty acids. SPMs promote resolution of inflammation reduced in Alzheimer's disease. It is unknown whether associated with post-stroke cognitive impairment (PSCI).In the present report, we aimed to study levels PSCI patients acute phase ischemic stroke.Levels plasma 36 33 non-cognitive (PSNCI) were measured by enzyme immunoassay.We found that SPM lipoxin A4 (LXA4) significantly compared...
Traditional SrTiO3 (STO) materials have high brittleness and poor deformation resistance. In this work, macroscopically flexible iron-doped (SFTO) nanofibrous membranes were prepared by electrospinning calcination, which can be easily isolated maintain integrity to recycle as photocatalysts. Moreover, the SFTO showed enhanced photocatalytic performance under strong acids (pH = 2) alkalis 12). The increased catalytic rate of Congo red (CR) dye about 10 times in visible light. mechanism...