A5102809881- Molecular Biology Techniques and Applications
- Forensic and Genetic Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Multiple Sclerosis Research Studies
- Rheumatoid Arthritis Research and Therapies
- RNA Research and Splicing
- Peripheral Neuropathies and Disorders
- Identification and Quantification in Food
- Barrier Structure and Function Studies
- Medical Imaging Techniques and Applications
- Environmental DNA in Biodiversity Studies
- Alcoholism and Thiamine Deficiency
- Geochemistry and Geochronology of Asian Mineral Deposits
- Forensic Anthropology and Bioarchaeology Studies
- Ion channel regulation and function
- Chemokine receptors and signaling
- Epigenetics and DNA Methylation
- Cardiovascular Effects of Exercise
- Animal health and immunology
- Advanced Glycation End Products research
- Advanced Nanomaterials in Catalysis
- Archaeology and ancient environmental studies
- Probiotics and Fermented Foods
Shanghai Sixth People's Hospital
2015-2025
Shanghai Jiao Tong University
2009-2025
Fujian Medical University
2020-2024
Union Hospital
2021-2023
Second Affiliated Hospital of Fujian Medical University
2023
Shanxi Medical University
2000-2022
Nankai University
2014
Hunan University of Science and Technology
2010
Abstract Age prediction is of great importance for criminal investigation and judicial expertise. DNA methylation status considered a promising method to infer tissue age by virtue age‐dependent changes on sites. In recent years, forensic scientists have established various models predict the chronological blood, saliva, semen based status. However, hair‐inferred has not been studied in field science. this study, we measured statuses potential age‐related CpG sites using multiplex SNaPshot...
Severe hypoglycemia induces brain edema by upregulating aquaporin-4 (AQP4) expression and degrading tight junctions. Acute severe a proinflammatory environment that may contribute to disruption in the epithelial barrier decreasing junction protein expression. Interestingly, altered AQP4 has been considered play critical role neuroinflammation during acute injury. It shown deletion reduces inflammation AQP4-null mice after intracerebral LPS injection. However, effect of regarding protection...
<title>Abstract</title> Background and purpose: Alzheimer's disease (AD) is a neurodegenerative characterized by progressive cognitive dysfunction, which common in the elderly. In recent years, it has been reported that glucagon-like peptide 1 (GLP-1) analogues have neuroprotective function. However, mechanism of GLP-1 improving neurological function not fully clarified. This study attempts to clarify alleviating AD phenotype. Methods: this study, modified once-weekly analogue, Semaglutide,...
Abstract Objective This study investigated the spinal changes in ligature‐induced periodontitis and role of cognitive impairment. Methods Twenty mice were randomized into control chronic (CP) groups, with latter receiving periodontitis. Cognitive performance was assessed by fear conditioning test. Periodontal inflammation alveolar bone resorption evaluated micro‐computed tomography histopathology. The hippocampal microglial activation immunohistochemistry (IHC). expressions cytokines (TNF‐α,...
Abstract In the past decades, messenger RNA (mRNA) biomarkers have been employed to identify origin of body fluids in forensic medicine. We hypothesized that polymorphism mRNA could be applied individuals mixture samples composed two fluids. this study, we selected five blood‐specific venous blood (SPTB, CD3G, AMICA1, ANK1, and GYPA) encompass 16 SNPs contributor(s). Five specific gene markers for menstrual blood, semen, skin, saliva, vaginal secretions were amplified typed as body‐fluid...
Recent studies suggest that high-salt diet is associated with cognitive decline in human and mouse. The fact genetic factors account for less than 50% cases of sporadic Alzheimer's disease (AD) highlights the important contribution environmental factors, such as diet, AD pathogenesis. However, whether how fits "amyloid cascade" hypothesis remains unexplored. Here, we show sodium chloride (NaCl) could increase Aβ levels medium HEK293 cells overexpressing amyloid precursor protein (APP) or C99...
Abstract Background Hepatic encephalopathy (HE) is closely associated with inflammatory responses. However, as a crucial regulator of the immune and responses, role leucine-rich repeat kinase 2 (LRRK2) in pathogenesis HE remains unraveled. Herein, we investigated this issue thioacetamide (TAA)-induced following acute liver failure (ALF). Methods TAA-induced mouse models LRRK2 wild type (WT), G2019S mutation ( Lrrk2 ) knockout (Lrrk2 −/− were established. A battery neurobehavioral experiments...
Mutations of the leucine-rich repeat kinase 2 (LRRK2) gene are associated with pronounced sleep disorders or cognitive dysfunction in neurodegenerative diseases. However, effects LRRK2 deficiency on rhythms and deprivation-related changes, relevant underlying mechanism, remain unrevealed. In this study, Lrrk2-/- Lrrk2+/+ mice were subjected to normal (S) deprivation (SD). Sleep recording, behavioral testing, Golgi-cox staining, immunofluorescence, real-time PCR employed evaluate impacts...
Recent studies have shown that mTOR signaling plays an important role in synaptic plasticity. However, the function of S6K1, mechanistic target rapamycin kinase complex 1 (mTORC1) substrate, epilepsy remains unknown. Our present study aimed to explore mechanism by which S6K1 is involved chronic epilepsy. First, immunostaining was used measure neurite length and complexity kainic acid (KA)-treated primary cultured neurons treated with PF-4708671, a highly selective inhibitor. We obtained...
Retracted.
Associations between gene variations and sudden cardiac arrest or coronary artery disease have been reported by genome‑wide association studies. However, the implication of genetic status in cases death (SCD) from Chinese Han population has remained to be investigated. The present study established a mini‑sequencing system examine putative death‑causing single nucleotide polymorphisms (SNPs) using multiplex PCR, base extension reaction capillary electrophoresis techniques. A total 198...