A5100359699- Acute Ischemic Stroke Management
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Advanced Biosensing Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Functional Brain Connectivity Studies
- Pharmaceutical Economics and Policy
- Autism Spectrum Disorder Research
- Innovation Policy and R&D
- Health Systems, Economic Evaluations, Quality of Life
- Firm Innovation and Growth
- Cellular transport and secretion
- Adrenal Hormones and Disorders
- Cancer Research and Treatments
- Mental Health Research Topics
- Ion Channels and Receptors
- Intellectual Property and Patents
- Phagocytosis and Immune Regulation
- Treatment of Major Depression
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Retinal and Optic Conditions
- Galectins and Cancer Biology
Huashan Hospital
2021-2025
Fudan University
2019-2025
First Affiliated Hospital of Jinan University
2023-2025
Chengdu University of Traditional Chinese Medicine
2024
Chengdu Fifth People's Hospital
2024
Women and Children’s Health Research Institute
2024
University of Alberta
2024
Peking University
2023
National Bureau of Economic Research
2023
University of California, San Diego
2023
Power analysis is a key component for planning prospective studies such as clinical trials. However, some journals in biomedical and psychosocial sciences ask power data already collected analysed before accepting manuscripts publication. In this report, post hoc retrospective examined the informativeness of understanding detecting significant effects results analysed, using same on which based, scrutinised. Monte Carlo simulation used to investigate performance posthoc analysis.
BACKGROUND: Whether it is effective and safe to extend the time window of intravenous thrombolysis up 24 hours after last known well unknown. We aimed determine efficacy safety tenecteplase in Chinese patients with acute ischemic stroke due large/medium vessel occlusion within an extended window. METHODS: Patients presenting 4.5 from well, a favorable penumbral profile associated occlusion, were randomized 1:1 either 0.25 mg/kg or best medical treatment. A was defined as hypoperfusion lesion...
Venous outflow (VO) is emerging as a marker of microvascular integrity in acute ischemic stroke. Using hemorrhagic transformation (HT) and infarct growth mediators, we tested whether favorable VO profile benefited functional outcome by reducing consequences dysfunction.
Importance Tirofiban is a nonpeptide antagonist of the glycoprotein IIb/IIIa receptor that inhibits platelet aggregation selectively. Despite widespread use in acute ischemic stroke conjunction with endovascular treatment, role tirofiban uncertain. Objective To assess whether intravenous initiated before thrombectomy improves outcomes by achieving first-pass recanalization without intracranial hemorrhagic risk. Design, Setting, and Participants This was multicenter, prospective, open-label,...
Abstract Hematogenous metastasis is the main approach for colorectal cancer liver (CRCLM). However, as gatekeepers in tumor vessels, role of TPCs hematogenous remains largely unknown, which may be attributed to lack specific biomarkers TPC isolation. Here, microdissection combined with a pericyte medium‐based developed obtain from CRC patients. Proteomic analysis reveals that TRP channel‐associated factor 2 (TCAF2), partner protein transient receptor potential cation channel subfamily M...
Metastatic BRAFV600E colorectal cancer (CRC) confers poor prognosis and represents a therapeutic bottleneck. To identify resistance mechanisms of the mitogen-activated protein kinase (MAPK) pathway in CRC, we perform genome-wide CRISPR-Cas9 screening discover that targeting glutathione peroxidase 4 (GPX4) overcomes to BRAF inhibitor (BRAFi) combined with or without epidermal growth factor receptor (EGFRi) CRC. Specifically, BRAFi ± EGFRi upregulates GPX4 expression, which antagonizes...
Background and purpose Tenecteplase (TNK) has demonstrated non-inferiority to alteplase in patients who had an acute ischaemic stroke presenting within 4.5 hours from symptom onset. The trial is aimed explore the efficacy safety of TNK Chinese with large/medium vessel occlusion extended time window. Methods design Acute Tissue-Based Imaging Selection for Lysis In Stroke II (CHABLIS-T II) a multicentre, prospective, block-randomised, open-label, blinded-endpoint, phase IIb study. Eligible are...
To date, few structural models of VHH antibody binding to low molecular weight haptens have been reported. Here, we report the crystal structure cortisol its NbCor at pH 3.5 and 10.5. Cortisol binds mainly by burying itself under tunnel formed complementarity determining region 1 ( CDR 1) NbCor. The affinity similar compounds was also verified a microscale thermophoresis assay. Combining our findings with several previously reported structures hapten‐ complexes, propose that antibodies...
Background: Depression is a major psychiatric disorder and the leading cause of disability worldwide. Previous evidence suggested certain pattern structural alterations were induced by depression (MDD) with heterogeneity due to patients' clinical characteristics proposed that early impairment fronto-limbic-striatal circuit was involved. Yet hypothesis couldn't be replicated fully. Accordingly, this study aimed validate in new set first-episode, drug naïve MDD patients further explore...
Abstract Aims The aim of this study was to explore the interaction between reperfusion and treatment time on outcomes patients undergoing endovascular presenting within 24 h last known well, compare predictive ability different measurements outcomes. Methods Eligible from a single‐center cohort were enrolled in study. Reperfusion assessed using index (decreased volume hypoperfusion lesion compared with baseline) measured by repeated perfusion imaging, modified cerebral ischemia score digital...
Abstract Emotion cognitive remediation is a critical component of social skills training for children with autism spectrum disorder (ASD). Visual perception emotions highly correlated the intensity and sequence presented emotions. However, few studies examined effect presentation on emotion perception. The present study gaze patterns ASD in receiving different sequences using eye‐tracking technologies. Gaze ecologically‐valid video clips silent stimuli by 51 34 typically developing (TD) were...
Some colorectal cancer patients still face high recurrence rates and poor prognoses even after they have undergone the surgical treatment of radical resection. Identifying potential biochemical markers therapeutic targets for prognostic evaluation undergoing resection is crucial improving their clinical outcomes. Recently, it has been reported that T cell immunoglobulin mucin domain protein 3 (Tim-3) its ligand galactose lectin 9 (galectin-9) play roles in immune dysfunction caused by...
Abstract Background Early diagnosis of large vessel occlusion (LVO) in acute stroke often requires CT angiography (CTA). Automated perfusion (CTP) software, which identifies blood flow abnormalities, enhances LVO and patient selection for endovascular thrombectomy (EVT). This study evaluates the sensitivity automated CTP images detecting abnormalities patients with ischemic (AIS) or medium (MeVO), compared to CTA. Methods We screened presenting within 24 h who underwent CT, CTA, as per...
Abnormal alterations in enzymes functioned sialic acid modifications may be associated with ASD. In order to study the differences peripheral blood sialidase (neuraminidase 1; NEU1) mRNA expression between autism spectrum disorder (ASD) children and healthy control, examine correlation NEU1 main behavioral phenotypes ASD, we performed RT-qPCR measure of 42 ASD controls. addition, used Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) evaluate Our results showed that group was...
TPS6102 Background: Novel combination therapies are needed to extend survival in patients (pts) with recurrent or metastatic head and neck squamous cell carcinoma (RM-HNSCC). Magrolimab is a monoclonal antibody that blocks CD47, "don't eat me" signal often overexpressed on HNSCC cells. CD47 blockade by magrolimab induces macrophage-mediated phagocytosis of tumor cells has shown preclinical activity promising clinical efficacy hematologic malignancies. Certain chemotherapies, including...
This study investigates how enhanced regulation can promote innovation, focusing on the impacts of a significant regulatory reform in China's pharmaceutical sector implemented 2015. Inspired by practices U.S., aimed to address application backlogs and reduce administrative waiting time for new drug development. Using data at firm levels during 2012--2021, we make three main findings: (1) categories experiencing improved approval times witnessed surge investigational applications related...
In this paper, a human-like driving framework is designed for autonomous vehicles (AVs), which aims to make AVs better integrate into the transportation ecology of human and eliminate misunderstanding incompatibility drivers driving. Based on analysis real world INTERACTION dataset, aggressiveness estimation model established with fuzzy inference approach. Then, model, integrates brain emotional learning circuit (BELCM) two-point preview designed. lane-change decision-making algorithm, cost...