A5014381800- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Neurological Disease Mechanisms and Treatments
- Crystallography and molecular interactions
- Intracerebral and Subarachnoid Hemorrhage Research
- Atrial Fibrillation Management and Outcomes
- Retirement, Disability, and Employment
- Regional Development and Environment
- Obsessive-Compulsive Spectrum Disorders
- Medical Research and Treatments
- S100 Proteins and Annexins
- Advancements in Battery Materials
- Advanced Battery Technologies Research
- Brain Tumor Detection and Classification
- Phonocardiography and Auscultation Techniques
- Health disparities and outcomes
- Evaluation Methods in Various Fields
- Ear Surgery and Otitis Media
- Vestibular and auditory disorders
- Music and Audio Processing
Ningbo First Hospital
2018-2024
Ningbo University Affiliated Hospital
2024
Ningbo University
2023-2024
University of Science and Technology Beijing
2023
Shaanxi Provincial People's Hospital
2021
Shanxi Medical University
2021
The University of Melbourne
2020
The Royal Melbourne Hospital
2020
First Affiliated Hospital of Chengdu Medical College
2019
Beijing Anding Hospital
2017
In acute ischemic stroke, there is uncertainty regarding the benefit and risk of administering intravenous alteplase before endovascular thrombectomy.We conducted a trial at 41 academic tertiary care centers in China to evaluate thrombectomy with or without patients stroke. Patients stroke from large-vessel occlusion anterior circulation were randomly assigned 1:1 ratio undergo alone (thrombectomy-alone group) preceded by alteplase, dose 0.9 mg per kilogram body weight, administered within...
<h3>Objective</h3> To test the hypothesis that patients with acute ischemic stroke poorer collaterals would have faster core growth, we included 2 cohorts in study: cohort 1 of 342 for derivation and 414 validation. <h3>Methods</h3> Patients large vessel occlusion were included. Core growth rate was calculated by following equation: = volume on CT perfusion (CTP)/time from onset to CTP. Collateral status assessed ratio severe hypoperfusion within region The CTP collateral index categorized...
Background and Purpose: This study aimed to evaluate the treatment effect of intraarterial versus intravenous tirofiban during endovascular thrombectomy in acute ischemic stroke. Methods: retrospectively examined 503 patients with stroke large vessel occlusion who received within 24 hours onset. Patients were divided into 3 groups: no (n=354), (n=79), (n=70). The groups compared terms recanalization rate, symptomatic intracerebral hemorrhage, in-hospital death 3-month death, outcomes...
Background and Purpose— This study aimed to explore safety of tirofiban in endovascular treatment acute ischemic stroke. Methods— Two hundred eighteen stroke patients receiving thrombectomy were prospectively recruited, with 94 treated intra-arterial 124 not. The 2 groups compared terms symptomatic intracranial hemorrhage (ICH) fatal ICH rate by the χ test logistic regression. Results— Patients those without had significantly higher (14.6% versus 5.7%; P =0.027) (8.8% 1.6%; =0.014)....
Background and purpose Tirofiban is used off‐label in clinical practice for acute ischaemic stroke ( AIS ). However, it unknown whether tirofiban increases the bleeding risk or improves outcome of endovascular treatment EVT ) . This study evaluated efficacy safety combination with Methods Consecutive patients receiving were included prospective registry from 2015 to 2018. The outcomes modified Rankin Scale mRS score at 3 months National Institutes Health Stroke NIHSS 24 h. symptomatic...
<h3>Background and Objectives</h3> It is still uncertain that going direct to endovascular thrombectomy (EVT) leads equivalent outcomes as bridging IV thrombolysis (IVT) in acute ischemic patients. This study aimed explore whether the rate of core growth influenced patient after IVT vs EVT. <h3>Methods</h3> was a retrospective cohort based on International Stroke Perfusion Imaging Registry (INSPIRE). selected stroke patients receiving perfusion CT within 4.5 hours onset. Patients who went...
Background The performance of intravenous tenecteplase in patients who had an acute ischaemic stroke with large/medium vessel occlusion or severe stenosis extended time window remains unknown. We investigated the promise efficacy and safety different doses manufactured China, beyond 4.5-hour window. Methods CHinese Acute tissue-Based imaging selection for Lysis In Stroke-Tenecteplase was investigator-initiated, umbrella phase IIa, open-label, blinded-endpoint, Simon’s two-stage randomised...
Introduction: Our collaborative team has previously developed a prognostic model for acute ischemic stroke (AIS). This model, known as the clinical decision support system (CDSS), aims to provide personalized assistance clinicians in making treatment decisions and improving patient prognosis. The objective of this study was externally validate using Chinese AIS patients. Methods: All enrolled patients arrived at hospital within 24 hours after onset. primary outcome likelihood favorable...
Abstract JOURNAL/nrgr/04.03/01300535-202406000-00039/inline-graphic1/v/2023-10-30T152229Z/r/image-tiff Post-acute ischemic stroke hyperglycemia increases the risk of hemorrhagic transformation, which is associated with blood-brain barrier disruption. Brain microvascular endothelial cells are a major component barrier. Intercellular mitochondrial transfer has emerged as novel paradigm for repairing dysfunction. In this study, we first investigated whether exists between brain cells, and then...
Atrial fibrillation (AF) is associated with poorer functional outcomes in acute stroke patients. It has been hypothesized that this due to poor collateral recruitment.This study aimed investigate the relationship between AF and collaterals outcome thrombectomy patients.This retrospective cohort identified 1036 ischemic patients from INternational Stroke Perfusion Imaging REgistry. The was divided into two groups: 432 604 without AF. Patients were stratified by grades as good, moderate, poor....
Objective We hypothesized that quantitative net water uptake (NWU), a novel neuroimaging marker of early brain edema, can predict symptomatic intracranial hemorrhage (sICH) after acute ischemic stroke (AIS). Methods enrolled patients with AIS who completed admission multimodal computed tomography (CT) within 24 h onset. NWU the core and penumbra was calculated based on CT, namely NWU-core NWU-penumbra. sICH defined as presence ICH in infarct area 7 days onset, accompanied by clinical...
Background This retrospective observational cohort study aimed to evaluate whether tenecteplase’s use for acute ischemic stroke (AIS) has time management advantages and clinical benefits. Methods 144 AIS patients treated with alteplase 120 tenecteplase were included. We compared baseline characteristics, key reperfusion therapy indices [onset-to-treatment (OTT), door-to-needle (DNT), door-to-puncture (DPT)] outcomes (24-h post-thrombolysis NIHSS improvement, intracranial hemorrhage...
Background and Purpose: This study aimed to explore whether the therapeutic benefit of endovascular thrombectomy (EVT) was mediated by core growth rate. Methods: retrospective cohort identified acute ischemic stroke patients with large vessel occlusion receiving reperfusion treatment, either EVT or intravenous thrombolysis (IVT), within 4.5 hours onset. Patients were divided into 2 groups: versus IVT only (who had no access EVT). Core rate estimated volume on perfusion computed tomography...
Background: There is limited experience in the community with intravenous tissue plasminogen activator (rt-PA) administered 3 to 4.5 hours after acute ischemic stroke (AIS) onset. Many patients do not meet entry criteria of pivotal clinical trials because severe stroke, age >80, hypertension (sHTN), or history previous and diabetes. Whether rt-PA benefits these unclear. Thus, we investigated outcomes treated without adverse characteristics. Methods: Chart review AIS at a single...
To investigate the difference in early edema, quantified by net water uptake (NWU) based on computed tomography (CT) between ischemic core and penumbra to explore predictors of NWU test its predictive power for clinical outcome.Retrospective analysis was conducted patients admitted Ningbo First Hospital with anterior circulation stroke multi-modal CT. In 154 included patients, were calculated compared Mann-Whitney U test. Correlations variables including age, infarct time (time from symptom...
We aimed to compare Perfusion Imaging Mismatch (PIM) and Clinical Core (CCM) criteria in ischemic stroke patients identify the effect of these on selected patient population characteristics clinical outcomes. Patients from INternational Stroke REgistry (INSPIRE) who received reperfusion therapy, had pre-treatment multimodal CT, 24-h imaging, 3 month outcomes were analyzed. divided into cohorts: endovascular thrombectomy (EVT), intravenous thrombolysis alone with large vessel occlusion...
Abstract Aims The aim of the study was to develop a simple and objective score using clinical variables quantified perfusion measures identify embolic stroke with large vessel occlusions. Methods Eligible patients from five centers participating in International Stroke Perfusion Imaging Registry were included this study. Patients split into derivation cohort ( n = 213) validation 116). A developed according coefficients independent predictors stepwise logistic regression model cohort....
Abstract BACKGROUND AND PURPOSE Tenecteplase was demonstrated pharmacological superiority over alteplase, potentially translating into clinical benefits. Numerous studies have confirmed that the effectiveness and safety of tenecteplase in acute ischemic stroke (AIS) treatment may not be inferior to it has potential workflow advantages. This study aimed evaluate whether tenecteplase’s use routine practice time management advantages corresponding METHODS The included AIS patients treated with...
<sec><title>Objective</title> To compare the effect of anesthesia mode on neurological functional outcomes in patients undergoing endovascular treatment for acute posterior circulation ischemic stroke. </sec><sec><title>Methods</title> Conscious sedation and general clinical data 656 intravascular therapy stroke registered online Acute Stroke Patients Management Quality Evaluation Database from January 2017 to December 2022 were retrospectively analyzed, including 163 cases received...
Background Falls frequently occur among the older adult population. In this study, we examined variations in fall incidence across different regions over time, focusing on disparities between urban and rural areas Chinese individuals, Healthy aging is comprised of five dimensions: (1) absence chronic diseases, (2) good physical functioning, (3) normal cognitive function, (4) active social participation, (5) depression. Additionally, explored relationship healthy occurrence falls middle-aged...