A5034927282- Liver Disease Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Hepatitis B Virus Studies
- Alcohol Consumption and Health Effects
- Colorectal Cancer Screening and Detection
- Global Cancer Incidence and Screening
- Liver Disease and Transplantation
- Hepatitis C virus research
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Esophageal and GI Pathology
- COVID-19 and Mental Health
- Diabetes Treatment and Management
- Misinformation and Its Impacts
- COVID-19 epidemiological studies
- Cervical Cancer and HPV Research
- MicroRNA in disease regulation
- Medical Research and Treatments
- Immune cells in cancer
- Head and Neck Cancer Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Diabetes Management and Research
- Case Reports on Hematomas
Kunming Medical University
2023-2024
Henan Cancer Hospital
2019-2024
Zhengzhou University
2019-2024
Hainan Medical University
2024
Sun Yat-sen University
2024
Xiangtan University
2022
Peking University
2019
Shanghai Sixth People's Hospital
2017
Shanghai Jiao Tong University
2017
Central South University
2017
Background The COVID-19 pandemic has threatened the health systems of many countries worldwide. Several studies have suggested that affects not only physical but also all aspects society. A lot information been reported about disease since beginning outbreak. For reason, it is essential to investigate attitudes and level knowledge awareness different populations had regarding during critical period Objective This study aimed assess toward among in Central China Methods cross-sectional...
Upper gastrointestinal cancer (UGC) screening has been widely implemented in many Asian countries. However, there is little evidence of participation and diagnostic yields population-based UGC China. The rate detection upper lesions this program were reported related factors explored. analysis was conducted the context Cancer Screening Program Urban China, which recruited 179 002 eligible participants aged 40-74 years from three cities Henan province 2013 to 2017. A total 43 423 evaluated be...
Colorectal cancer (CRC) screening has been widely implemented in Europe and the USA. However, there is little evidence of participation diagnostic yields population-based CRC China. The rate detection colorectal lesions this program were reported related factors explored. analysis was conducted context Cancer Screening Program Urban China, which recruited 282,377 eligible participants aged 40-74 years from eight cities Henan province 2013 to 2019. A total 39,834 evaluated be high risk for by...
<h3>Importance</h3> Lung cancer screening has been widely implemented in Europe and the US. However, there is little evidence on participation diagnostic yields population-based lung China. <h3>Objective</h3> To assess rate detection of a program factors associated with participation. <h3>Design, Setting, Participants</h3> This cross-sectional study used data from Cancer Screening Program Urban China October 2013 to 2019, follow-up until March 10, 2020. The conducted at centers 8 cities...
About 15% of lung cancers in men and 53% women are not attributable to smoking worldwide. The aim was develop validate a simple non-invasive model which could assess stratify cancer risk non-smokers China.A large-sample size, population-based study conducted under the framework Cancer Screening Program Urban China (CanSPUC). Data on screening Henan province, China, from October 2013 2019 were used randomly divided into training validation sets. Related factors identified through...
Abstract Background Annual screening through low-dose computed tomography (LDCT) is recommended for heavy smokers. However, it questionable whether all individuals require annual given the potential harms of LDCT screening. This study examines benefit–harm and cost-effectiveness risk-based in smokers determines optimal risk threshold risk-stratified intervals. Methods We conducted a comparative analysis China, using cohort-based Markov model which simulated lung cancer cohort 19,146 aged 50...
Abstract Previous studies have shown that scutellarin inhibits the excessive activation of microglia, reduces neuronal apoptosis, and exerts neuroprotective effects. However, whether regulates activated microglia-mediated apoptosis its mechanisms remains unclear. This study aimed to investigate can attenuate PC12 cell induced by microglia via JAK2/STAT3 signalling pathway. Microglia were cultured in oxygen–glucose deprivation (OGD) medium, which acted as a conditioning medium (CM) activate...
Hyperuricemia contributes to kidney tubular injury and fibrosis. However, the underlying mechanism remains unclear. Here we examined role of RTN1A, a novel endoplasmic reticulum (ER)-associated protein ER stress in hyperuricemic nephropathy. We first found expression RTN1A markers was significantly increased biopsies hyperuricemia patients with injury. In rat model nephropathy (HN) established by oral administration mixture adenine potassium oxonate, shown interstitial compartment kidneys....
Two large randomized controlled trials (RCTs) have demonstrated that low dose computed tomography (LDCT) screening reduces lung cancer mortality. Risk-prediction models been proved to select individuals for effectively. With the focus on established risk factors routinely available in general settings, we aimed develop and internally validated a prediction model cancer.Using data from Cancer Screening Program Urban China (CanSPUC) Henan province, between 2013 2019, conducted prospective...
MicroRNAs (miRNAs) act as biomarkers for the diagnosis of a variety cancers. Since currently used methods miRNA detection have limitations, simple, sensitive, and cost-effective are required. This work demonstrates facile, quencher-free, fluorescence-based analytical method sensitive using super 2-aminopurine (2-AP)-labeled hairpin probe (HP) exonuclease I activity. Specifically, fluorescence 2-AP is strongly quenched when it incorporated within DNA. In presence target miRNA, HP attains an...
Objectives: The human papillomavirus (HPV) vaccination rate is generally low in China. This study aimed to assess the effect of web-based education on improving information-motivation-behavior skills related HPV among Chinese female college students. Methods: From February May 2020, students were recruited from a university and divided into intervention control groups. group received 7 days HPV-related education. Related information collected using questionnaires baseline, days, 1 month, 3...
Objective: To evaluate the compliance of low-dose computed tomography (LDCT) screening for high-risk groups lung cancer and influencing factors in urban area Henan province during 2013-2017. Methods: Cluster sampling method was used to select residents 40-74 years old risk factor investigation assessment. Subjects with high received LDCT screening. The differences receiving rates between were compared χ(2) tests, time trend tested Cochran- Armitage test. potential correlating identified...
Background: It is great of significance to figure the time-trend esophageal cancer (EC) and its current status for effective prevention control, especially in EC high risk areas. As one world-renowned high-risk areas, epidemiology Henan has not been recently updated. Therefore, we aimed depict quo analyze Henan.
Objective: To investigate the inhibitory effect of AKR1B10 inhibitor combined with sorafenib on hepatocellular carcinoma (HCC) xenograft growth. Methods: HepG2 model was established in nude mice. The mice were then randomly divided into four groups: control group, epalrestat monotherapy group and combination treatment group. Tumor volume, tumor weight, T/C ratio change body weight each compared to evaluate curative effect. Immunohistochemistry staining used detect expression Ki-67 tissues...
China bears heavy disease burden of cervical cancer, but the willingness to receive human papillomavirus (HPV) vaccine is low. This study aimed assess factors affecting Chinese female college students HPV based on information-motivation-behavior skills (IMB) model. A cross‑sectional was carried out in Henan University Engineering February 2020. Demographic characteristics and IMB model variables were collected using an anonymous questionnaire. structural equation constructed influencing...
Background The World Health Organization has proposed a worldwide target of eliminating hepatitis C virus (HCV) by 2030. A better understanding HCV, testing behaviors, and associated factors in the general population is essential. Objective This study aimed to assess HCV knowledge, self-reported behavior, willingness undergo screening Chinese population. Methods cross-sectional online survey aged ≥15 years was conducted from November 2021 May 2023. Participant characteristics were assessed...
Objective: To evaluate the efficacy of lung cancer screening in urban areas Henan province by low-dose computed tomography (LDCT) from 2013 to 2017. Methods: A cluster sampling method was used select residents 40-74 years old investigate risk factors and conduct assessment. Subjects with high received LDCT for screening. Results: total 179 002 completed assessment, 35 672 subjects were identified as cancer, a rate 19.93%. 13 383 LDCT, 37.52%. There 786 cases diagnosed positive nodules,...
Objective: To study the compliance of endoscopic screening for high-risk population upper gastrointestinal cancer and relevant factors in urban areas Henan Province, 2013-2017. Methods: The participants were from Cancer Screening Program Urban China. From October 2013 to 2017, 43 423 residents, who evaluated as cancer, recruited Zhengzhou, Zhumadian Anyang. risk assessment questionnaire was used collect basic demographic characteristics, dietary habits, living environment psychology...