A5101481718- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- HER2/EGFR in Cancer Research
- Cancer Mechanisms and Therapy
- Breast Implant and Reconstruction
- Fibroblast Growth Factor Research
- Global Cancer Incidence and Screening
- Kruppel-like factors research
- Cancer and Skin Lesions
- Cancer Risks and Factors
- Cancer Treatment and Pharmacology
- Metastasis and carcinoma case studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Diagnosis and Treatment
- Circular RNAs in diseases
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Cancer Genomics and Diagnostics
- Advanced Breast Cancer Therapies
- Biomarkers in Disease Mechanisms
- AI in cancer detection
Guangzhou University
2025
Sun Yat-sen University
2013-2024
Sun Yat-sen Memorial Hospital
2013-2024
Key Laboratory of Guangdong Province
2018
National Natural Science Foundation of China
2016
GTx (United States)
2015
The University of Texas Southwestern Medical Center
2014
Bridge University
2014
Breast Center
2011
Abstract Background Tumor-associated macrophages (TAMs) are alternatively activated cells induced by interleukin-4 (IL-4)-releasing CD4 + T cells. TAMs promote breast cancer invasion and metastasis; however, the mechanisms underlying these interactions between tumor that lead to metastasis remain elusive. Previous studies have found microRNAs (miRNAs) circulating in peripheral blood identified microvesicles, or exosomes, as mediators of cell-cell communication. Therefore, one alternative...
Axillary lymph node metastasis (ALNM) status, typically estimated using an invasive procedure with a high false-negative rate, strongly affects the prognosis of recurrence in breast cancer. However, preoperative noninvasive tools to accurately predict ALNM status and disease-free survival (DFS) are lacking.To develop validate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) radiomic signatures for identification assess individual DFS patients early-stage cancer.This...
in current clinical practice, the standard evaluation for axillary lymph node (ALN) status breast cancer has a low efficiency and is based on an invasive procedure that causes operative-associated complications many patients. Therefore, we aimed to use machine learning techniques develop efficient preoperative magnetic resonance imaging (MRI) radiomics approach of ALN explore association between tumor microenvironment patients with early-stage cancer.in this retrospective multicenter study,...
A major obstacle to developing small interfering RNAs (siRNAs) as cancer drugs is their intracellular delivery disseminated cells. Fusion proteins of single-chain fragmented antibodies (ScFvs) and positively charged peptides deliver siRNAs into specific target However, the therapeutic potential ScFv-mediated siRNA has not been evaluated in cancer. Here, we tested whether Polo-like kinase 1 (PLK1) complexed with a Her2-ScFv-protamine peptide fusion protein (F5-P) could suppress Her2(+) breast...
A high neutrophil-to-lymphocyte ratio (NLR) may be related to increased mortality in patients with lung, colorectal, stomach, liver, and pancreatic cancer. To date, the utility of NLR predict response neoadjuvant chemotherapy (NAC) has not been studied. The aim our study was determine whether is a predictor NAC investigate prognostic impact on relapse-free survival (RFS) breast cancer-specific (BCSS) cancer who received NAC.We retrospectively studied subsequent surgical therapy for stage...
Tamoxifen resistance is accountable for relapse in many ER-positive breast cancer patients. Most of these recurrent patients receive chemotherapy, but their chemosensitivity unknown. Here, we report that tamoxifen-resistant cells express significantly more BARD1 and BRCA1, leading to DNA-damaging chemotherapy including cisplatin adriamycin, not paclitaxel. Silencing or BRCA1 expression inhibition phosphorylation by Dinaciclib restores the sensitivity cells. Furthermore, show activated...
Background MicroRNA-27a (miR-27a) is thought to be an onco-microRNA that promotes tumor growth and metastasis by downregulating ZBTB10. The potential predictive value of miR-27a was studied in breast cancer patients. Methods expression ZBTB10 examined 102 cases using situ hybridization (ISH) immunohistochemistry techniques were evaluated semi-quantitatively examining the staining index. Correlation analyed Spearman Rank Correlation. association with clinicopathological characteristics...
Previous trials showed that antiangiogenesis or anti-programmed death protein 1/programmed ligand 1 (PD-1/PD-L1) monotherapy only marginal effect in triple-negative breast cancer (TNBC). Preclinical studies demonstrated antiangiogenic therapy could sensitize to PD-1/PD-L1 blockade via reprogramming tumor microenvironment. Combinational treatment of checkpoint and for TNBC has not been reported.Patients with advanced less than three lines systemic were enrolled an open-label, non-comparative,...
Phyllodes tumors of breast, even histologically diagnosed as benign, can recur locally and have metastatic potential. Histologic markers only limited value in predicting the clinical behavior phyllodes tumors. It remains unknown what drives malignant progression We found that expression myofibroblast markers, α-smooth muscle actin (α-SMA), fibroblast activation protein (FAP), stromal cell-derived factor-1 (SDF-1), is progressively increased Microarray showed miR-21 was one most significantly...
Emerging evidence has indicated nerve fibers as a marker in the progression of various types cancers, such pancreatic cancer and prostate cancer. However, whether are associated with breast remains unclear. In this study, we evaluated presence 352 specimens 83 benign tissue including 43 cases cystic fibrosis 40 fibroadenoma from 2 independent tumor center using immunohistochemical staining for specific peripheral fiber markers. all, were present 130 out specimens, while none detected normal...
Breast cancer patients with high proportion of stem cells (BCSCs) have unfavorable clinical outcomes. MicroRNAs (miRNAs) regulate key features BCSCs. We hypothesized that a biology-driven model based on BCSC-associated miRNAs could predict prognosis for the most common subtype, hormone receptor (HR)-positive, HER2-negative breast patients.After screening candidate literature review and pilot study, we built miRNA-based classifier using LASSO Cox regression method in training group (n=202)...
Desert encroachment significantly threatens the living and activity space of humanity, undertaking human-directed vegetation restoration is one effective ways to prevent desert expansion. In process restoration, counting number tree saplings for rapidly assessing survival rate (such as Haloxylon ammodendron) a critical task within process. However, traditional ground-based statistical methods are resource-intensive time-consuming. This paper proposed novel unsupervised fine segmentation...
Chemotherapy resistance remains an important problem in the breast cancer clinic. The ability to predict patients who would respond a distinct therapy help optimize tailored treatment options. miRNAs can mediate number of genes response drug-induced acute cellular stress. Several studies suggest that let-7 miRNA may be involved chemosensitivity cell lines vitro. However, it is not known whether this phenomenon occurs clinical tumors. present study showed lower let-7a expression was...
Current tumor-node-metastasis (TNM) stage is unable to accurately predict the overall survival (OS) in breast cancer (BC) patients. This study aimed construct a microRNA (miRNA)-based model improve prediction of BC. We confirmed 99 differentially expressed miRNAs (DEMs) 1044 BC samples compared 102 adjacent normal tissues from The Cancer Genome Atlas (TCGA) database. Prognostic DEMs were used establish miRNA-based nomogram via Cox regression model. Gene ontology (GO) and Kyoto Encyclopedia...
Circulating tumor cells (CTCs) are seeds for cancer metastasis and predictive of poor prognosis in breast patients. Whether CTCs primary (PTCs) respond to chemotherapy differently is not known. Here, we show that more resistant than PTCs because potentiated DNA repair. Surprisingly, the chemoresistance was recapitulated when they were detached from extracellular matrix. Detachment increased levels reactive oxygen species partially activated damage checkpoint, converting a CTC-like state....