A5101805638- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- HER2/EGFR in Cancer Research
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Salivary Gland Tumors Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Cancer Immunotherapy and Biomarkers
- Brain Metastases and Treatment
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis B Virus Studies
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Viral-associated cancers and disorders
- Hepatitis C virus research
- Ferroptosis and cancer prognosis
- Healthcare and Venom Research
- Pancreatitis Pathology and Treatment
- Educational Robotics and Engineering
- Lymphoma Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
The First People's Hospital of Shunde
2021
Southern Medical University
2021
Chinese University of Hong Kong
2016-2020
Southern Medical University Shenzhen Hospital
2020
Guangdong Academy of Medical Sciences
2019
Guangdong Provincial People's Hospital
2019
University of Hong Kong
2017
Sun Yat-sen University
2011-2014
Sun Yat-sen Memorial Hospital
2011-2014
The First People's Hospital of Zhaoqing
2014
Background & AimsGemcitabine resistance is rapidly acquired by pancreatic ductal adenocarcinoma (PDAC) patients. Novel approaches that predict the gemcitabine response of patients and enhance chemosensitivity are important to improve patient survival. We aimed identify genes as novel biomarkers therapeutic targets attenuate chemoresistance in PDAC cells.MethodsGenome-wide RNA interference screening was conducted regulated chemoresistance. A cell proliferation assay a tumor formation were...
The effect of breast cancer subtype on margin status after lumpectomy remains unclear. This study aims to determine whether approximated is associated with positive margins lumpectomy, which could be used if there an increased risk developing local recurrence (LR) following breast-conserving surgery. We studied 1,032 consecutive patients invasive who received lumpectomies and cavity (CM) assessments from January 2003 November 2012. data were collected: patient age, cT stage, pT grade, CM,...
The purpose of this study was to investigate the recurrence pattern and characteristics patients based on 2013 St. Gallen surrogate molecular subtypes after breast-conserving surgery (BCS) in Chinese women.This retrospective analysis included 709 consecutive breast cancer undergoing BCS from 1999-2010 at our institution. Five different were created using combined expression estrogen receptor, progesterone human epidermal growth factor receptor-2. Locoregional relapse-free survival (LRRFS),...
Non-small cell lung cancer (NSCLC) is the predominant subtype of cancers. KRAS mutation second most prevalent in NSCLC. mutant cells suppress anti-tumor T response. However, underlying mechanism still unknown. Here, we analyzed differential expression acetyl-CoA acyltransferase 1 (ACAA1) various types cancers using TIMER database and validated results NSCLC line H1944. We silenced oncogenic by siRNA targeting KRASG13D, employed an MAPK signaling pathway inhibitor to clarify possible...
Objective To investigate the feasibility of 3M liquid dressing as radiotherapy surface marker.Methods 15 tumor patients undergoing radiation therapy were randomly divided into observation group (n =10) and control =5).Observation sprayed marker with dressing,made a mark in original position after was completely dry,then again.The operation repeated 2 times.Observed area clear degree daily,sprayed again if fuzzy until end treatment.Recorded spraying frequency interval time,observed patients'...
Abstract Pancreatic cancer is an extremely lethal with a 5-year survival rate of 7%. One major reason why pancreatic hard to treat its metastasis nature. Genes that related the tumorigenesis and progression were identified after decades efforts. Several researches had revealed originated from successive accumulation gene mutations, especially KRAS2, CNKD2A, TP53 SMAD4. However, little known about genes regulate metastasis. Here we used genome wide CRISPR Cas9 screening identify gene(s)...
Abstract This study aimed to investigate the key role and mechanism of GADD45B in radiation resistance nasopharyngeal carcinoma (NPC) cell lines. Radiotherapy-resistant HONE1 (HONE1-R) cells with stable genetic radioresistance were cultured under continuous stimulation. CCK-8 clone formation assays used verify line. Transcriptome sequencing was identify most important differential signaling pathway Quantitative reverse transcription polymerase chain reaction (qRT-PCR) Western blot analysis...