A5063927658- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Macrophage Migration Inhibitory Factor
- RNA modifications and cancer
- Circadian rhythm and melatonin
- Immune cells in cancer
- IL-33, ST2, and ILC Pathways
- Vitamin C and Antioxidants Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Respiratory Support and Mechanisms
- Brain Metastases and Treatment
- Nutrition, Health and Food Behavior
- Inhalation and Respiratory Drug Delivery
- Bone health and treatments
- Parkinson's Disease Mechanisms and Treatments
- Sodium Intake and Health
- Endoplasmic Reticulum Stress and Disease
- Organic Electronics and Photovoltaics
- PI3K/AKT/mTOR signaling in cancer
- Chronic Myeloid Leukemia Treatments
- Cancer, Hypoxia, and Metabolism
- Nuclear Receptors and Signaling
- Coastal wetland ecosystem dynamics
- Neonatal Respiratory Health Research
- Silymarin and Mushroom Poisoning
The First People's Hospital of Shunde
2020-2025
Southern Medical University
2020-2025
South China University of Technology
2024-2025
Zhejiang University
2022
Hangzhou First People's Hospital
2022
Chongqing University of Arts and Sciences
2019
First Affiliated Hospital of Jinan University
2018
Jinan University
2016
Shenzhen University
2014
SHARPIN is a tumor-associated gene involved in the growth and proliferation of many tumor types. A function cholangiocarcinoma (CCA) so far unclear. Here, we studied role CCA revealed its relevant molecular mechanism. The expression was analyzed tissues from patients using immunohistochemistry, quantitative PCR, western blot analysis. Expression suppressed/overexpressed by siRNA silencing or lentiviral overexpression vector, effect on cell determined CCK-8 assay flow cytometry. Accumulation...
Abstract Activation of metabolic signalling by IL-15 is required for natural killer (NK) cell development. Here we show that Tsc1, a repressor mTOR, dispensable the terminal maturation, survival and function NK cells but critical to restrict exhaustive proliferation immature activation downstream during Tsc1 expressed in upregulated IL-15. Haematopoietic-specific deletion causes marked decrease number compromises rejection ‘missing-self’ haematopoietic tumours allogeneic bone marrow. The...
The lipopolysaccharide-induced acute lung injury (ALI) mouse model is used to simulate human respiratory distress syndrome (ARDS), which has a high mortality rate. An imbalance between M1 and M2 macrophages, characterised by an increase in was observed sepsis-induced ALI. We report that laminarin, active ingredient found algae, exhibits exceptional performance of It ameliorates edema, enhances the survival rate mice reduces levels inflammatory factors TNF-α IL-6. Furthermore, laminarin...
In this work, we studied influence of post thermal annealing on the performance and charge photogeneration processes PffBT4T-2OD/PC71BM solar cells. As-prepared device exhibits a high-power conversion efficiency 9.5%, much higher than that after annealing. To understand phenomenon, in these cells by means time resolved spectroscopy. We associate degradation cell with reduction exciton dissociation increased bimolecular recombination photogenerated charges as result correlate generation...
Long-term subjection to shift work increases the risk of cancer. The purpose present study was explore mechanism by which chronic circadian disruption impairs natural killer (NK) cell immunosurveillance. Mice were subjected light-dark reverse every 4 days for 12 weeks disrupt normal rhythm. NK development and function evaluated flow cytometry. mRNA protein levels period 1 (per1) per2 suppressed, while locomotor output cycle kaput (CLOCK) increased in shifted mice, indicating successful...
Metabolic reprogramming is a sign of malignant tumors, and targeting the metabolism tumor cells has become promising therapeutic approach. Here, we report that Silybin (a nontoxic flavonoid commonly used for liver protection) exhibits prominent anti-tumor effects on human ovarian cancer cells. Treatment an cell line with interfered glutamine tricarboxylic acid cycle. We applied drug affinity responsive target stability approach to show binds isocitrate dehydrogenase 1 (IDH1). This...
A high-salt diet (HSD) is common worldwide and can lead to cardiovascular disease, chronic inflammation, autoimmune diseases. Moreover, increasing evidence shows that HSD closely related a variety of immune Natural killer (NK) cells are important innate directly kill their targets via degranulation secretion interferon gamma (IFN-γ). NK play vital role in resisting viruses preventing the malignant transformation cells; however, whether affects development function has not yet been...
Abstract Rheumatoid arthritis (RA) is a common autoimmune disease that can lead to irreversible joint damage when it occurs, but its pathogenesis has not yet been elucidated. In this study, we explored the roles of macrophage migration inhibitory factor (MIF), endoplasmic reticulum stress (ER stress), and Th17 cells in RA. We have preliminarily confirmed MIF expression CD4 + T proportion are increased active RA patients. also found ER activated, initiating ATF6 pathway UPR. Additionally,...
Astrocytes are a major constituent of the central nervous system (CNS). Astrocytic oxidative stress contributes to development Parkinson’s disease (PD). Maintaining production antioxidant and detoxification reactive oxygen nitrogen species (ROS/RNS) in astrocytes is critical prevent PD. Study has illuminated that ascorbic acid (AA) stimulates dopamine synthesis expression tyrosine hydroxylase human neuroblastoma cells. However, role regulatory mechanisms AA on still unclear. The purpose our...
Excitatory neurotoxicity caused by the accumulation of glutamate in synaptic cleft is an important cause Parkinson's disease (PD). Astrocyte transporter 1 (GLT-1) main responsible for transporting glutamate, and investigations toward regulation GLT-1 astrocytes can reveal insights. Vitamin C (VC) has protective effects on brain, but its effect expression unclear. The purpose this study was to explore any regulatory VC clarify possible mechanism such regulation. We found that impaired...
Intrahepatic mucinous cholangiocarcinoma (IMCC) is a rare subtype of intrahepatic (IHCC). Limited data describe the genetic characteristics IMCC and insights on its pathogenesis are lacking. Here, we employed multi-omics approach to analyze somatic mutations, transcriptome, proteome metabolome tumor tissue obtained from case in order clarify IMCC. A total 54 mutations were detected, including G12D mutation KRAS that likely be involved onset The genes consistently up-regulated at...
Ventilator-associated pneumonia (VAP) is one of the most common infectious diseases in patients undergoing mechanical ventilation intensive care unit (ICU). Although use closed sputum suction tube for nursing measure with tracheal intubation ICU, and it also an important to reduce occurrence VAP, existing clinical technology still needs external flushing solution humidification flushing. In process use, operation has risk that amount fluid cannot be controlled, resulting a large entering...
Abstract This study aimed to investigate the key role and mechanism of GADD45B in radiation resistance nasopharyngeal carcinoma (NPC) cell lines. Radiotherapy-resistant HONE1 (HONE1-R) cells with stable genetic radioresistance were cultured under continuous stimulation. CCK-8 clone formation assays used verify line. Transcriptome sequencing was identify most important differential signaling pathway Quantitative reverse transcription polymerase chain reaction (qRT-PCR) Western blot analysis...