A5070404677- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Cancer-related molecular mechanisms research
- Cardiac Arrest and Resuscitation
- Neuroendocrine regulation and behavior
- MicroRNA in disease regulation
- Cardiovascular and Diving-Related Complications
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Immune Cell Function and Interaction
- Cardiac tumors and thrombi
- Coronary Artery Anomalies
- Immune Response and Inflammation
- Neuroscience of respiration and sleep
- Kawasaki Disease and Coronary Complications
- Immune cells in cancer
- Nuclear Receptors and Signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Atrial Fibrillation Management and Outcomes
- Galectins and Cancer Biology
- Phytochemical compounds biological activities
- Intensive Care Unit Cognitive Disorders
- Dietary Effects on Health
- Cardiac Fibrosis and Remodeling
- Phytochemistry and Bioactive Compounds
Sichuan University
2022-2024
West China Hospital of Sichuan University
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Tsinghua University
2018-2022
Qilu Hospital of Shandong University
2022
Kunming Medical University
2013-2021
First Affiliated Hospital of Kunming Medical University
2019-2021
Zigong First People's Hospital
2021
Second People's Hospital of Yunnan Province
2017
China Pharmaceutical University
2015
The interaction of SIRPα with CD47 represents a major mechanism for preventing macrophage phagocytosis. However, CD47-independent mechanisms are poorly defined. Here, we report critical role SLAM family receptors (SFRs), ubiquitously expressed on hematopoietic cells and forming homotypic interactions, in constraining We found that SFR deficiency triggered phagocytosis cells, leading to severe rejection donor graft recipient mice. Specific members, mainly SLAMF3 SLAMF4, were identified as...
Myocardial ischemia/reperfusion (I/R) injury is a common cause of mortality. Cardiac miR-146a emerging as potent regulator myocardial function. Dexmedetomidine preconditioning provides cardioprotective effects, which mechanisms related to miR-146a-3p are unclear. A I/R model in rats and cellular anoxia/reoxygenation (A/R) H9C2 cells were established preconditioned with dexmedetomidine or not. transfected mimics, inhibitor, negative controls miR-146a-3p, siRNAs IRAK1 TRAF6. Relative...
Dexmedetomidine (Dex) has been reported to be cardioprotective. Differential expression of miR-208b-3p is associated with myocardial injury. But it unknown that aberrant implicated in protection Dex. Hypoxia/reoxygenation (HR) model was established H9C2 cells. qRT-PCR performed detect levels undergoing HR, Dex preconditioning, overexpression or inhibition, and assess Med13 following knockdown mRNA. CCK8 and, flow cytometry Western blot were conducted respectively examine viability, apoptosis...
Oxytocin (OT) has shown a cardioprotective effect on myocardial ischemia/reperfusion injury (MIRI). This study aimed to investigate whether the of OT is associated with inhibition mast cell degranulation and inflammation. The left anterior descending coronary artery rats was ligated for 30 min reperfused 120 establish an ischemia reperfusion (I/R) model. A preliminary experiment conducted evaluate optimal dose (0.01, 0.1, 1 μg/kg via intraperitoneal). secretagogue compound 48/80 (C48/80)...
The degranulation of cardiac mast cells is associated with occurrence and development myocardial ischemia/reperfusion (I/R) injury. Dexmedetomidine has a cardioprotective effect from I/R purpose this study was to investigate whether dexmedetomidine preconditioning induced cardioprotection related suppression cell. Both in vivo vitro experimental results revealed that hemodynamic disorder, arrhythmia, infarct size, histopathological score, cell were dramatically increased injury groups...
Cardiac hypertrophy is caused by cardiac volume or pressure overload conditions and ultimately leads to contractile dysfunction heart failure. Oxytocin (OT), an endocrine nonapeptide, has been identified as a cardiovascular homeostatic hormone with anti-hypertrophic effects. However, the underlying mechanism remains elusive. In this study, we aimed investigate role of OT in hypertrophy. The rats induced isoproterenol (ISO) were treated without oxytocin. functional parameters analyzed...
Diabetic cardiovascular diseases (DCVDs) are the most common complications of diabetes mellitus and considered to be one important threats global health an economic burden. Long noncoding RNA (lncRNA), circular (circRNA), miRNA a novel group RNAs that involved in regulation various pathophysiological processes, including DCVDs. Interestingly, both lncRNA circRNA can act as competing endogenous miRNA, thereby regulating expression target mRNA by decoying or sponging miRNA. In this review, we...
Myocardial infarction (MI) resulting from acute coronary ischemia may cause significant morbidity and mortality, microRNAs play a vital role in this pathophysiology. Limonin (LIM) is natural medicine citrus fruit that protects organs against ischemic diseases, but the candidate genes pathways associated with cardioprotection are unknown.MI was induced by ligating left anterior descending male Sprague-Dawley rats. LIM orally administered for 7 days after induction of MI. Subsequently, hearts...
A 49-year-old man presented to the hospital with symptoms of acute cerebral infarction and pulmonary embolism who underwent transcatheter closure atrial septal defect a year before. Transthoracic echocardiography showed 13 × 9 mm hypoechoic mass attached left-atrial side device, which was suspected be neoplasm or thrombus. The patient indicated for surgery after multidisciplinary discussion due ineffective medical therapy typical stroke symptoms. Three-dimensional transesophageal (3D-TEE)...
To investigate the underlying mechanism of bone marrow mesenchymal stem cells (BMSC) modulating inflammatory response during multiple organ dysfunction syndrome (MODS), especially expression cytokines, which will provide new theoretical and experimental basis MODS in clinic.BMSC Sprague-Dawley (SD) rat (female, 4 weeks) was extracted cultivated, 4th passage were used study. According to random number table, 60 female SD rats divided into three groups (n = 20 per group): sham group, BMSC...
To determine the effect of bone mesenchymal stem cells (BMSCs) in transplantation therapy for lipopolysaccharide (LPS)-induced coagulation disorder and underlying mechanism high mobility group protein B1-receptors advanced glycation end products/Toll-like receptors-nuclear factor-κB (HMGB1-RAGE/TLRs-NF-κB) signaling pathway.BMSCs female Sprague-Dawley (SD) rats ageing 4-5 weeks old were extracted cultivated vitro, fourth-passaged BMSCs phenotype was identified by flow cytometry following...
Cardiomyocyte hypertrophy is considered to be a compensatory process of heart suffering from pathological damages. This study aimed evaluate effects Na+/K+ APTaseα2 (NAKα2) on isoprenaline (ISO) induced cardiomyocyte hypertrophy.Mouse atrial cardiomyocytes were cultured and treated with ISO establish model. NAKα2 over-expression small interfere RNA (siRNA) plasmids constructed transfected cardiomyocytes. Influx Ca2+ ([Ca2+]i) was measured using flow cytometry method. Fibrosis formation...
A 50-year-old female presented with a history of fatigue after activities. Transthoracic echocardiography showed 2.8 cm dilatation at the ostium left coronary artery and 7.1×7.4 cyst-like aneurysm upper back atrium, interlinking an anomalous fistula from to right atrial appendage, accompanied by moderate mitral tricuspid regurgitation. Cardiac 3D-computed tomography identified diagnosis ruptured aortic sinus (RASA) giant atrium. Transesophageal echocardiogram surgical vision confirmed these...
A 49-year-old male presented to hospital with symptoms of acute cerebral infarction and pulmonary embolism who underwent transcatheter closure atrial septal defect a year ago. Transthoracic echocardiography showed 13×9 mm hypoechoic mass attached the left-atrial side device, which was suspected be neoplasm or thrombus. The patient indicated for surgery after multidisciplinary discussion due ineffective medical therapy typical stroke symptoms. Three-dimensional transesophageal (3D-TEE)...
A 50-year-old women presented with a history of fatigue after activities. Transthoracic echocardiography showed 2.8 cm dilatation at the ostium left coronary artery and 7.1 × 7.4 cyst-like aneurysm upper back atrium, interlinking an anomalous fistula from to right atrial appendage, accompanied by moderate mitral tricuspid regurgitation. Cardiac 3D-computed tomography confirmed diagnosis ruptured aortic sinus (RASA) giant atrium. transesophageal echocardiogram surgical vision these findings....