A5048572583- Berberine and alkaloids research
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Lipid metabolism and disorders
- Pharmacological Effects of Natural Compounds
- Reproductive System and Pregnancy
- Adipose Tissue and Metabolism
- Ginseng Biological Effects and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Chromatography in Natural Products
- Natural Antidiabetic Agents Studies
- Plant-based Medicinal Research
- Medicinal Plant Pharmacodynamics Research
- Cholesterol and Lipid Metabolism
- Cannabis and Cannabinoid Research
- Diet and metabolism studies
- Chronic Kidney Disease and Diabetes
- Growth Hormone and Insulin-like Growth Factors
- Dietary Effects on Health
- Circadian rhythm and melatonin
- Healthcare and Venom Research
- Traditional Chinese Medicine Studies
- Metabolomics and Mass Spectrometry Studies
Huazhong University of Science and Technology
2016-2025
Tongji Hospital
2016-2025
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
Shandong First Medical University
2009-2022
Academy of Medical Sciences
2020
Binzhou Medical University
2014
Collaborative Research Group
2012
Tulane University
2012
University of the Sciences
2010
COVID-19 is highly contagious, and the crude mortality rate could reach 49% in critical patients. Inflammation concerns on disease progression. This study analyzed blood inflammation indicators among mild, severe patients, helping to identify or patients early.In this cross-sectional study, 100 were included divided into groups according condition. Correlation of peripheral inflammation-related with criticality was analyzed. Cut-off values for critically ill speculated through ROC...
Abstract Aim The new coronavirus (COVID-19) pneumonia outbreaking at the end of 2019 is highly contagious. Crude mortality rate reached 49% in critical patients. Inflammation matters on disease progression. This study analyzed blood inflammation indicators among mild, severe and patients, helping to identify or patients early. Methods In this cross-sectional study, 100 were included divided groups. Correlation peripheral inflammation-related with criticality was analyzed. Cut-off values for...
Elevated levels of plasma free fatty acid (FFA) and disturbed mitochondrial dynamics play crucial roles in the pathogenesis diabetic kidney disease (DKD).However, mechanisms by which FFA leads to damage glomerular podocytes DKD effects Berberine (BBR) on are not fully understood.Methods: Using db/db mice model cultured mouse podocytes, we investigated molecular mechanism FFA-induced disturbance testified BBR regulating dysfunction, podocyte apoptosis glomerulopathy progression DKD.Results:...
Oxidative stress and inflammation play essential roles in the development progression of diabetic nephropathy (DN). Baicalin (BAI), a natural flavonoid, has been showed to have renoprotective effect various renal diseases. However, its underlying mechanisms DN remain unclear. In this study, we explored potential effects BAI on using spontaneous model.The protective evaluated by detecting DN-related biochemical indicators, kidney histopathology cell apoptosis. After that, examined level...
Glycolysis, a simple pathway of glucose metabolism, critically regulates insulin secretion and metabolic functions various cells. Depending on cell types, rates glycolysis are determined at steps that subjected to the control key regulatory enzyme(s), which include glucokinase, 6-phosphofructo-1-kinase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. These enzymes regulated by both nutritional hormonal signals levels transcription, translation, post-translational modifications. In...
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic and characterized by excessive hepatic lipid accumulation. Many studies have suggested that overload key initial factor contributes to steatosis. Our previous study indicated diosgenin (DSG) has a beneficial effect on energy metabolism, but underlying mechanism remains unclear.Human normal hepatocytes (LO2 cells) were incubated with palmitic acid establish cell model of nonalcoholic liver. The effects DSG glucose uptake...
The interaction between fat deposition and inflammation during obesity contributes to the development of non-alcoholic fatty liver disease (NAFLD). present study examined effects palmitoleate, a monounsaturated acid (16∶1n7), on metabolic inflammatory responses, investigated mechanisms by which palmitoleate increases hepatocyte synthase (FAS) expression. Male wild-type C57BL/6J mice were supplemented with subjected assays analyze hepatic steatosis response. Additionally, mouse primary...
Background and Purpose Disordered lipid metabolism disturbed mitochondrial bioenergetics play pivotal roles in the initiation development of diabetic kidney disease (DKD). Berberine is a plant alkaloid, used Chinese herbal medicine. It has multiple therapeutic actions on diabetes mellitus its complications, including regulation glucose metabolism, improvement insulin sensitivity, alleviation oxidative damage. Here, we investigated reno‐protective effects berberine. Experimental Approach We...
Background: Intestinal mucosal barrier dysfunction plays an important role in the development of diabetes mellitus (DM). Berberine (BBR), a kind isoquinoline alkaloid, is widely known to be effective for both DM and diarrhea. Here, we explored whether anti-diabetic effect BBR was related intestine barrier. Methods Results: The rat model T2DM established by high glucose fat diet feeding intravenous injection streptozocin. Then, those diabetic rats were treated with at different concentrations...
More than 70% of patients with type 2 diabetes (T2DM) concomitantly suffer from Non-alcoholic fatty liver disease (NAFLD), and the coexistence interaction them increases intractability NAFLD. With protective effect against hepatic steatosis fibrosis, SIRT6 is becoming a notable target Diosgenin, an active monomer Chinese herbs, has been reported to protect NAFLD.This study aims figure out mechanism how diosgenin alleviate NAFLD in T2DM relationship SIRT6.In vivo studies used spontaneous...
Depression is a major global health issue that urgently requires innovative and precise treatment options. In this context, saikosaponin has emerged as promising candidate, offering variety of therapeutic benefits may be effective in combating depression. This review delves into the multifaceted potential saikosaponins alleviating depressive symptoms. We summarized effects on structural functional neuroplasticity, elaborated regulatory mechanism modulating key factors affect such...
Liver sinusoidal endothelial cells (LSECs) are highly specialized that represent the interface between blood on one side and hepatocytes other side. LSECs not only form a barrier within hepatic sinus, but also play important physiological functions such as regulating vascular pressure, anti-inflammatory anti-fibrotic. Pathologically, pathogenic factors can induce capillarization, is, loss of fenestra dysfunction, which conducive to early steatosis, lay foundation for progression metabolic...
Increasing evidence demonstrates the dissociation of fat deposition, inflammatory response, and insulin resistance in development obesity-related metabolic diseases. As a regulatory enzyme glycolysis, inducible 6-phosphofructo-2-kinase (iPFK2, encoded by PFKFB3) protects against diet-induced adipose tissue response systemic independently adiposity. Using aP2-PFKFB3 transgenic (Tg) mice, we explored ability targeted adipocyte PFKFB3/iPFK2 overexpression to modulate responses arising from...
Abstract Backgrounds Inflammation is recognized as the key pathological mechanism of type 2 diabetes. The hypoglyceamic effects berberine (BBR) are related to inhibition inflammatory response, but not completely clear. Methods polarization Raw264.7 cells and primary peritoneal macrophages were induced by LPS, then underlying mechanisms BBR explored. An model was established LPS treatment at different concentrations for time. ELISA assay used detect secretions TNF-α. RT-PCR applied M1...