A5064188865- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- X-ray Diffraction in Crystallography
- Cancer Treatment and Pharmacology
- Crystallization and Solubility Studies
- Advanced Breast Cancer Therapies
- MRI in cancer diagnosis
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Breast Cancer Treatment Studies
- Medical Imaging Techniques and Applications
- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- RNA modifications and cancer
- Metal-Organic Frameworks: Synthesis and Applications
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Mycobacterium research and diagnosis
- Metal complexes synthesis and properties
Sun Yat-sen Memorial Hospital
2017-2025
Sun Yat-sen University
2017-2025
Macau University of Science and Technology
2022-2025
Zen-Noh (Japan)
2024
Beijing Normal University - Hong Kong Baptist University United International College
2021-2023
Beijing Normal University
2021-2023
Hong Kong Baptist University
2021-2023
Southern Medical University
2016-2023
Second Hospital of Yichang
2023
Bridge University
2023
Axillary lymph node metastasis (ALNM) status, typically estimated using an invasive procedure with a high false-negative rate, strongly affects the prognosis of recurrence in breast cancer. However, preoperative noninvasive tools to accurately predict ALNM status and disease-free survival (DFS) are lacking.To develop validate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) radiomic signatures for identification assess individual DFS patients early-stage cancer.This...
in current clinical practice, the standard evaluation for axillary lymph node (ALN) status breast cancer has a low efficiency and is based on an invasive procedure that causes operative-associated complications many patients. Therefore, we aimed to use machine learning techniques develop efficient preoperative magnetic resonance imaging (MRI) radiomics approach of ALN explore association between tumor microenvironment patients with early-stage cancer.in this retrospective multicenter study,...
Background Durable efficacy of immune checkpoint blockade (ICB) occurred in a small number patients with metastatic gastric cancer (mGC) and the determinant biomarker response to ICB remains unclear. Methods We developed an open-source TMEscore R package, quantify tumor microenvironment (TME) aid addressing this dilemma. Two advanced cohorts (RNAseq, N=45 NanoString, N=48) other (N=534) treated were leveraged investigate predictive value TMEscore. Simultaneously, multi-omics data from The...
<h3>Importance</h3> Long noncoding RNAs (lncRNAs) are involved in innate and adaptive immunity cancer by mediating the functional state of immunologic cells, pathways, genes. However, whether lncRNAs associated with immune molecular classification clinical outcomes immunotherapy is largely unknown. <h3>Objectives</h3> To explore lncRNA-based subtypes survival response to present a novel lncRNA score for prediction using computational algorithms. <h3>Design, Setting, Participants</h3> In this...
This review systematically describes and summarizes the application of nanotechnology-enabled sonodynamic therapy in malignant tumors.
Cervical cancer is a significant global health issue, its prevalence and prognosis highlighting the importance of early screening for effective prevention. This research aimed to create validate an artificial intelligence cervical (AICCS) system grading cytology. The AICCS was trained validated using various datasets, including retrospective, prospective, randomized observational trial data, involving total 16,056 participants. It utilized two (AI) models: one detecting cells at patch-level...
Abstract The exact function of M1 macrophages and CXCL9 in forecasting the effectiveness immune checkpoint inhibitors (ICIs) is still not thoroughly investigated. We investigated potential macrophage C‐X‐C Motif Chemokine Ligand 9 (CXCL9) as predictive markers for ICI efficacy, employing a comprehensive approach integrating multicohort analysis single‐cell RNA sequencing. A significant correlation between high improved overall survival (OS) objective response rate (ORR) was found. expression...
A novel five-coordinated Mn(II) polymer 1H-benzimidazole-5,6-dicarboxylato manganese (II) ([Mn(Hbidc)]n, 1) possessing abundant hydrogen bonds and π−π stacking interactions, synthesized by the hydrothermal reaction between MnSO4 a multifunctional organic aromatic ligand H3bidc, displays antiferromagnetic character, strong long-lived red luminescence (λmax = 726 nm τ 0.3 ms) as well high thermal stability (up to ca. 500 °C).
Background: Lung adenocarcinoma (LUAD), the most common subtype of non-small cell lung cancer (NSCLC), is associated with poor prognosis. However, current stage-based clinical methods are insufficient for survival prediction and decision-making. This study aimed to establish a novel model evaluating risk LUAD based on hypoxia, immunity, epithelial-mesenchymal transition (EMT) gene signatures. Methods: In this study, we used data from TCGA-LUAD training cohort GSE68465 GSE72094 validation...
Background Immune checkpoint inhibitors (ICIs)-based therapy, is regarded as one of the major breakthroughs in cancer treatment. However, it challenging to accurately identify patients who may benefit from ICIs. Current biomarkers for predicting efficacy ICIs require pathological slides, and their accuracy limited. Here we aim develop a radiomics model that could predict response with advanced breast (ABC). Methods Pretreatment contrast-enhanced CT (CECT) image clinicopathological features...
Conditional averages of the velocity field, subgrid-scale (SGS) stresses and SGS dissipation are calculated using fields obtained from DNS plane channel flow. The detection criteria isolate coherent turbulent structures that contribute most strongly to energy transfer between large, resolved scales subgrid, unresolved, ones. Separate computed for forward backward scatter. interscale is found be correlated with presence typical wall-bounded flows: quasi-streamwise hairpin vortices, sweeps...
Journal Article Accumulation of p53 Protein as a Possible Predictor Response to Adjuvant Combination Chemotherapy With Cyclophosphamide, Methotrexate, Fluorouracil, and Prednisone for Breast Cancer Get access Richard M. Elledge, Elledge Division Medical Oncology, The University Texas Health Science Center at San Antonio Search other works by this author on: Oxford Academic PubMed Google Scholar Robert Gray, Gray Biostatisties, Dana-Farber InstituteBosten, MA Edward Mansour, Mansour...
A novel 7-fold interpenetration diamondoid network neutral coordination polymer [Mn(NCP)2]n (HNCP = 2-(4-carboxyphenyl)imidazo(4,5-f)(1,10)phenanthroline), synthesized by the hydrothermal reaction between MnSO4 and a new designed multifunctional ligand HNCP, displays second harmonic generation efficiency that is approximately three times as much of potassium dihydrogen phosphate (KDP), weak antiferromagnetic character, strong fluorescence emission with λmax at 588 nm well high thermal...
Abstract Objectives To develop and validate a preoperative CT-based nomogram combined with radiomic clinical–radiological signatures to distinguish preinvasive lesions from pulmonary invasive lesions. Methods This was retrospective, diagnostic study conducted August 1, 2018, May 2020, at three centers. Patients solitary nodule were enrolled in the GDPH center divided into two groups (7:3) randomly: development ( n = 149) internal validation 54). The SYSMH ZSLC Center formed an external...
Abstract Oraxol, a novel oral paclitaxel chemotherapy agent, has emerged as potential alternative for treating metastatic breast cancer (MBC). However, its safety and efficacy remain uncertain due to insufficient evidence supporting it. This open‐label, single‐arm, phase I trial was designed assess the pharmacokinetics, safety, preliminary antitumor activity of Oraxol in previously treated MBC. The primary objective investigate pharmacokinetics while secondary endpoints included assessing...
Abstract Bladder cancer's high mortality underscores the need for precise staging, especially to differentiate between nonmuscle invasive bladder cancer (NMIBC) and muscle (MIBC) types. This prospective study evaluated efficacy of contrast‐enhanced ultrasound (CEUS) preoperative focusing on its ability distinguish NMIBC from MIBC. Conducted April 2020 September 2021, involved 163 patients (median age: 64.0 years; 137 males, 26 females), with 133 (81.6%) 30 MIBC (18.4%). Each patient...
CD36 plays a critical role in lipid metabolism, which is closely associated with human immunity.However, the of cancer remains unclear.We performed pan-cancer analysis to elucidate potential by investigating its prognostic value and current predictors for efficacy immune checkpoint inhibitors (ICIs) multiple types.CD36 expression cell lines, tumor tissue, their adjacent normal tissues displayed heterogeneity among different cancers.Immunohistochemistry was used detect confirmed results.CD36...
Aberrant activation of NFκB orchestrates a critical role in tumor carcinogenesis; however, the regulatory mechanisms underlying this are not fully understood. Here we report that novel long noncoding RNA (lncRNA) Uc003xsl.1 is highly expressed triple-negative breast cancer (TNBC) and correlates with poor outcomes patients TNBC. directly bound nuclear transcriptional factor NFκB-repressing (NKRF), subsequently preventing NKRF from binding to specific negative element promoter NFκB-responsive...
Objectives: We aimed to assess the performance of a deep learning (DL) model, based on combination ultrasound (US) and mammography (MG) images, for predicting malignancy in breast lesions categorized as Breast Imaging Reporting Data System (BI-RADS) US 4A diagnostic patients with dense breasts. Methods: A total 992 were randomly allocated into training cohort test at proportion 4:1. Another, 218 enrolled form prospective validation cohort. The DL model was developed by incorporating both MG...
Two novel cobalt(II) coordination polymers [Co2(H2O)4(Hbidc)2]n (1) and [Co(Hbidc)]n (2), (Hbidc = 1H-benzimidazole-5,6-dicarboxylate) were synthesized hydrothermally by treating CoSO4 H3bidc at 160 or 220 °C, respectively. X-Ray diffraction analyses showed that compound 1 is a 1-D chain polymer with dimer units [Co2(H2O)4(Hbidc)2] the infinite chains of array uniformly towards crystallographic a-axis in 3-D supramolecular framework which possesses abundant hydrogen-bonding interactions...