A5112512710- RNA Research and Splicing
- Children's Physical and Motor Development
- Gastric Cancer Management and Outcomes
- Birth, Development, and Health
- RNA modifications and cancer
- Physical Education and Training Studies
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Obesity, Physical Activity, Diet
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Treatments and Studies
- Chemokine receptors and signaling
- Lung Cancer Research Studies
- RNA and protein synthesis mechanisms
- Cancer and Skin Lesions
- Helicobacter pylori-related gastroenterology studies
- Genetic factors in colorectal cancer
- Cytokine Signaling Pathways and Interactions
- Thyroid Disorders and Treatments
- Autophagy in Disease and Therapy
- Diverse Approaches in Healthcare and Education Studies
- Ovarian cancer diagnosis and treatment
- Wnt/β-catenin signaling in development and cancer
- Nutrition, Genetics, and Disease
- Apelin-related biomedical research
Army Medical University
2024
Daping Hospital
2024
Columbia University
2007-2023
Chinese People's Liberation Army
2022
Fudan University Shanghai Cancer Center
2015-2020
Shanghai Medical College of Fudan University
2015-2020
Fudan University
2020
Peking University
2013-2016
Childhood obesity has been a serious public health problem. An effective school-based physical activity (PA) intervention is still lacking in China. This study aimed to assess the effectiveness of during 12 weeks on and related outcomes school children. It was non-randomized controlled trial. Altogether 921 children aged 7 15 years were recruited at baseline survey. Children group (n = 388) participated multi-component that included improvement education, extracurricular activities for...
Abstract Whole-genome sequencing of longitudinal tumor pairs representing transformation follicular lymphoma to high-grade B cell with MYC and BCL2 rearrangements (double-hit lymphoma) identified coding noncoding genomic alterations acquired during progression. Many these transformation-associated recurrently focally occur at topologically associating domain resident regulatory DNA elements, including H3K4me3 promoter marks located within H3K27ac super-enhancer clusters in non-Hodgkin...
The contribution of CXCL12/CXCR4/CXCR7 axis to cancer progression has been increasingly recognized. However, its role in thyroid development remains unclear. present study aimed examine the expression and function CXCL12 receptors cancer. human tissue specimens papillary, follicular, medullary, anaplastic carcinoma, follicular adenoma, Hashimoto's thyroiditis nodular goiter were examined by immunohistochemistry using a microarray. CXCR4 CXCR7 over-expressed cells K1 transduction recombinant...
B cell development is linked to successful V(D)J recombination, allowing receptor expression and ultimately antibody secretion for adaptive immunity. Germline noncoding RNAs (ncRNAs) are produced at immunoglobulin (Ig) loci during but their function posttranscriptional regulation incompletely understood. Patients with trichohepatoenteric syndrome, characterized by RNA exosome pathway component mutations, exhibit lymphopenia, thus demonstrating the importance of ncRNA surveillance in humans....
To analyse the clinicopathological, immunohistochemical and β-catenin (CTNNB1) mutation characteristics of six cases microcystic stromal tumour ovary (MCST).Six Chinese patients with MCST who ranged in age from 29 to 69 years (mean 50 years) were included study. Five detected a pelvic mass during routine health examinations one patient presented initially opsomenorrhoea. All tumours involved left ovary, solid-cystic cut surface five cystic case. Microscopically, microcysts, solid nests...
Periodontitis is a highly prevalent dental disease which associated with diabetes and challenging to cure in diabetic patients. However, the mechanism of comorbid periodontitis still unclear. This study aimed uncover role endoplasmic reticulum (ER) stress high glucose-associated periodontitis.Periodontal tissues were obtained from patients periodontitis, without systemic disease, healthy teeth. The expressions ER stress-related factors GRP78, ATF6, PERK XBP1 detected by quantitative...
ROS1 rearrangement has become an important biomarker for targeted therapy in advanced lung adenocarcinoma (LUAD). The study aimed to evaluate the prevalence of Chinese LUAD with EGFR wild-type and ALK fusion-negative status, analyze relationship their clinicopathological characteristics. A large cohort 589 patients EGFR/ALK wild-type, diagnosed between April 2014 June 2018, was retrospectively analyzed. all these cases detected by FISH, 8 selected different positive negative signals were...
The protein expression of programmed death-ligand 1 (PD-L1) has been recognised as being a biomarker for poor prognosis in diffuse large B-cell lymphoma (DLBCL). aims this study were to determine PD-L1 DNA status and mRNA status, explore whether they contribute their clinicopathological correlation DLBCL.In study, we used fluorescence in-situ hybridisation, RNA hybridisation immunohistochemistry at three different levels 287 DLBCL samples with follow-up. Their clinical pathological relevance...
Neoadjuvant immunochemotherapy (NAIC) markedly induces pathologic regression in locally advanced gastric adenocarcinoma. However, specific biomarkers are still lacking to effectively identify the beneficiary patients for NAIC.
Objective: To examine the association between rs10938397 polymorphism in glucosamine-6-phosphate deaminase 2 (GNPDA2) and risk of obesity children at different stages development analyze differences association. Methods: A total 3 503 school-aged were selected from Beijing Child Adolescent Metabolic Syndrome (BCAMS) study their complete anthropometry weight, height, fat mass percentage (FMP), index (FMI) free (FFMI) sexual maturation (SM) data used. The developmental evaluated using male...
Objective: The present study aimed to prospectively validate whether the single nucleotide polymorphisms (SNPs) in obesity-related genes were associated with change body mass index (BMI) and obesity status during childhood. Methods: Based on Beijing Child Adolescent Metabolic Syndrome (BCAMS), which was initiated between April October 2004, we conducted a follow-up among 1 624 children aged 6 11 years old genetic data December 2010. A total of 777 (246 obese 531 non-obese) reassessed for...