A5100765251- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Natural product bioactivities and synthesis
- Kruppel-like factors research
- Ion channel regulation and function
- Dermatologic Treatments and Research
- Genomics, phytochemicals, and oxidative stress
- Cardiovascular Function and Risk Factors
- Heavy Metal Exposure and Toxicity
- Metabolomics and Mass Spectrometry Studies
- Molecular Biology Techniques and Applications
- Genetic Syndromes and Imprinting
- Immune Response and Inflammation
- Peroxisome Proliferator-Activated Receptors
- Gut microbiota and health
- Nicotinic Acetylcholine Receptors Study
- Ginseng Biological Effects and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiac Ischemia and Reperfusion
- Phytoestrogen effects and research
- Fungal and yeast genetics research
- Neurotransmitter Receptor Influence on Behavior
- Trace Elements in Health
- Cancer-related molecular mechanisms research
- Pain Mechanisms and Treatments
Zhejiang Chinese Medical University
2025
First Affiliated Hospital of Bengbu Medical College
2025
Bengbu Medical College
2025
Xijing Hospital
2013-2024
Massachusetts General Hospital
2019-2024
Harvard University
2019-2024
Lanzhou University
2024
Anhui Medical University
2018-2023
Air Force Medical University
2001-2023
Peking Union Medical College Hospital
2021
The Inflammatory Load Index (IBI) and Body Roundness (BRI) were employed to evaluate the systemic inflammatory status body fat. This study aims elucidate association between IBI prevalence of gallstones, as well analyze mediating role BRI in this association. Data from National Health Nutrition Examination Survey (NHANES) (2017–2020) utilized our cross-sectional study. A total 2598 participants aged ≥ 20 years enrolled. Boruta algorithm, a supervised classification feature selection method,...
Abstract: Deficits of cortical nicotinic acetylcholine receptors (nAChRs) have been observed in Alzheimer’s disease (AD) by receptor binding assays. Little is known about the subunit specificity influenced AD, and it might be importance for therapeutic strategies. In present study, protein levels nAChR α3, α4, α7, β2 subunits were investigated using western blot analysis on postmortem brains patients with AD age‐matched controls. The results showed that human brain samples, bands molecular...
Abstract Irradiation (IR) induces immunogenic cell death (ICD) in tumors, but it rarely leads to the abscopal effect (AE); even combining IR with immune checkpoint inhibitors has shown only anecdotal success inducing AEs. In this study, we aimed enhance IR-induced response and generate reproducible AEs using anti-alcoholism drug, disulfiram (DSF), complexed copper (DSF/Cu) induce tumor ICD. We measured ICD vitro vivo. mouse models, DSF/Cu was injected intratumorally followed by localized IR,...
Objectives Primary Sjögren's syndrome (pSS) is an important cause of pulmonary arterial hypertension (PAH), which remains insufficiently studied and needs attention. This study aimed to investigate the clinical characteristics, risk factors, prognosis assessment pSS-PAH. Methods We established a multicentre cohort pSS-PAH diagnosed by right heart catheterisation. The case–control was conducted with pSS-non-PAH patients as control group identify factors for PAH. In study, survival calculated,...
In the context of acute ST-segment elevation myocardial infarction (STEMI), epicardial fat volume (EFV) has a significant impact on formation microvascular obstruction (MVO). This study aimed to quantitatively measure EFV and strain parameters by cardiac magnetic resonance (CMR) explore their relationship with presence or absence mcrocirculation dysfunction after infarction. was retrospective study. From June 2022 December 2023, 56 consecutive patients diagnosed STEMI who underwent...
Emerging studies have revealed that O-GlcNAcylation plays pivotal roles in the tumorigenesis of colorectal cancers (CRCs). However, underlying mechanism still remains largely unknown. Here, we demonstrated Yin Yang 1 (YY1) was O-GlcNAcylated by O-GlcNAc transferase (OGT) and YY1 could increase protein expression enhancing its stability. facilitated transformative phenotypes CRC cell a YY1-dependent manner. Also, stimulates transcriptional activity. Besides, also identified oncoproteins,...
Protein dimerization systems controlled by red light with increased tissue penetration depth are a highly needed tool for clinical applications such as cell and gene therapies. However, mammalian of existing light-induced hampered limitations their two components: photosensory protein (or photoreceptor) which often requires exogenous chromophore naturally occurring photoreceptor binding typically having complex structure nonideal properties. Here, we introduce an efficient, generalizable...
Notch signaling has been demonstrated to be involved in ductular reactions and fibrosis. Previous studies have shown that Huang Qi Decoction (HQD) can prevent the progression of cholestatic liver fibrosis (CLF). However, whether HQD affects pathway is unclear. In this study, CLF was established by common bile duct ligation (BDL) rats. At end first week, rats were randomly divided into a model group (i.e., BDL), an group, sorafenib positive control (SORA) treated for 3 weeks. Bile...
Abstract The intra-uterine and external environmental factors not only affect the early development of fetuses, their interaction with genesis will also substantially program physiological functions offspring throughout life. Synthetic glucocorticoid (GC) is widely used for management women at risk preterm birth or undergone autoimmune diseases. However, excess GC might cause a number chronic diseases in later In present study, we set up programming rat model by daily injection dexamethasone...
Functional dyspepsia (FD), a common gastrointestinal disorder around the world, is driven by multiple factors, making prevention and treatment major challenge.