A5056013078- Cell Adhesion Molecules Research
- Heme Oxygenase-1 and Carbon Monoxide
- Sirtuins and Resveratrol in Medicine
- S100 Proteins and Annexins
- Biochemical Analysis and Sensing Techniques
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Ion Channels and Receptors
- Hearing, Cochlea, Tinnitus, Genetics
- Mitochondrial Function and Pathology
- TGF-β signaling in diseases
- Liver physiology and pathology
Center for Life Sciences
2020-2024
Peking University
2020-2024
Abstract Myeloid lineage cells present the latent form of transforming growth factor-β1 (L-TGF-β1) to membrane using an anchor protein LRRC33. Integrin α V β 8 activates extracellular L-TGF-β1 trigger downstream signaling functions. However, mechanism designating specificity TGF-β1 presentation and activation remains incompletely understood. Here, we report cryo-EM structures human L-TGF-β1/LRRC33 integrin /L-TGF-β1 complexes. Combined with biochemical cell-based analyses, demonstrate that...
Transient Receptor Potential Melastatin 2 (TRPM2) cation channels contribute to immunocyte activation, insulin secretion, and central thermoregulation. TRPM2 opens upon binding cytosolic Ca 2+ ADP ribose (ADPR). We present here the 2.5 Å cryo-electronmicroscopy structure of from Nematostella vectensis (nvTRPM2) in a lipid nanodisc, complexed with ADPR-2′-phosphate. Comparison nvTRPM2 without nucleotide reveals that binding-induced movements protein’s three “core” layers deconvolve into set...