A5101824857- Central Venous Catheters and Hemodialysis
- Venous Thromboembolism Diagnosis and Management
- Vascular Procedures and Complications
- Gut microbiota and health
- Lipoproteins and Cardiovascular Health
- Virus-based gene therapy research
- Extracellular vesicles in disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Diet, Metabolism, and Disease
- Cardiac Imaging and Diagnostics
- Viral gastroenteritis research and epidemiology
- Functional Brain Connectivity Studies
- Chronic Kidney Disease and Diabetes
- Nerve injury and regeneration
- Immune Cell Function and Interaction
- Natural product bioactivities and synthesis
- Metabolomics and Mass Spectrometry Studies
- Liver Disease Diagnosis and Treatment
- Neurological disorders and treatments
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Atrial Fibrillation Management and Outcomes
- Nutrition, Genetics, and Disease
Ministry of Agriculture and Rural Affairs
2024
Huazhong Agricultural University
2024
Beijing University of Chinese Medicine
2020-2024
Sichuan University
2022-2024
West China Hospital of Sichuan University
2022-2024
Shanghai Children's Hospital
2024
Shanghai Jiao Tong University
2024
Zhejiang University of Technology
2023
Sichuan Agricultural University
2023
Central South University
2022
Abstract Background Postoperative cognitive dysfunction (POCD) is a common neurological complication following anesthesia and surgery. Increasing evidence has demonstrated that neuroinflammation caused by systemic inflammatory responses during the perioperative period key factor in occurrence of POCD. In addition, SMAD family member 7 (Smad7) been confirmed to play vital roles pathogenesis treatment diseases, such as bowel disease. However, whether Smad7 participates regulatory process...
Chronic pain is often associated with cognitive decline, which could influence the quality of patient's life. Recent studies have suggested that Toll-like receptor 3 (TLR3) crucial for memory and learning. Nonetheless, contribution TLR3 to pathogenesis decline after chronic remains unclear. The level in hippocampal neurons increased constriction injury (CCI) group than sham this study. Importantly, compared wild-type (WT) mice, knockout (KO) mice TLR3-specific neuronal knockdown both...
Oridonin is an active constituent isolated from the traditional Chinese herb Rabdosia rubescens, which exerts antitumor effects in experimental and clinical settings. However, its underlying mechanisms on prostate cancer cells have not yet been clearly identified. In present study, androgen-independent PC3 DU145 cell lines were used as models to investigate possible of oridonin cellular proliferation apoptosis. Results demonstrated that inhibited proliferation, was able significantly induce...
Type 3 resistant starch from Canna edulis (Ce-RS3) is an insoluble dietary fiber which could improve blood lipids in animals, but clinically robust evidence still lacking. We performed a double-blind randomized controlled trial to assess the effects of Ce-RS3 on mild hyperlipidemia. One hundred and fifteen patients were included followed recruitment criteria, randomly allocated receive or placebo (native edulis) for 12 weeks (20 g/day). In addition serum lipids, complete counts, inflammatory...
Background and objective: Vascular dementia (VaD) Alzheimer's disease (AD) could be characterized by the same syndrome of dementia. This study aims to assess whether multi-parameter features derived from structural MRI can serve as informative biomarker for differential diagnosis VaD AD using machine learning. Methods: A total 93 patients imaged with brain including 58 35 confirmed two chief physicians were recruited in this June 2013 July 2019. Automated tissue segmentation was performed...
As a severe metabolic disease, type 2 diabetes mellitus (T2DM) has aroused increasing public attentions. Resistant starch 3 (RS3), as resistant to enzymatic hydrolysis owing its special structure, good effect on improving insulin resistance and reducing blood sugar in T2DM patients. However, the possible mechanisms were barely interpreted yet. In our research, we aimed evaluate effects of RS3 treatment T2DM. ICR mice treated with high-fat diet (HFD) for eight weeks, then injected...
Background: Chronic neuropathic pain is commonly associated with memory loss, which increases the risk of dementia, lowers life quality and spending. On other hand, molecular processes are unknown, effective therapies have yet to be discovered. Long non-coding RNAs (lncRNAs) emerging potential therapeutic targets for chronic pain, but their role in pain-induced impairment unknown. Methods: We established a CCI-induced rat model. To investigate validate gene expression alterations hippocampus...
Drought stress is an important factor that reduces plant biomass production and quality. As one of the most economic forage grasses, orchardgrass (Dactylis glomerata) has high drought tolerance. Auxin/indole-3-acetic acid (Aux/IAA) early responsive gene families auxin plays a key role in response to stress. However, characteristics Aux/IAA family their potential function responding remain unclear. Here, 30 members were identified orchardgrass. Segmental duplication may be driving force...
Obesity is a most prevalent human health problem. Several studies showed that appropriate modulation of gut microbiota could help reshape the metabolic profile obese individuals, thereby altering development obesity. A nutritional strategy for treating obesity includes prebiotics. Type 3 Resistant Starch from Canna edulis (Ce-RS3) dietary fiber exerts potential effects on intestinal microbial community; however, landscape and anti-obesity mechanism remain unclear. In present study, mice were...
Aims To evaluate the correlation of nesfatin-1, GSH and SOD levels with β-cell insulin secretion their influence on in development type 2 diabetes mellitus (T2DM). Materials methods 75 patients T2DM, 67 prediabetes 37 heathy participants were recruited this study. Serum quantified statistically analyzed. Results The T2DM significantly decreased ( P < 0.001) compared to either or healthy control, significant reduction these biomarkers was also observed when control 0.001). Circulating...
Abstract Background The pathogenesis of memory impairment, a common complication chronic neuropathic pain (CNP), has not been fully elucidated. Schwann cell (SC)-derived extracellular vesicles (EVs) contribute to remote organ injury. Here, we showed that SC-EVs may mediate pathological communication between SCs and hippocampal neurons in the context CNP. Methods We used an adeno-associated virus harboring SC-specific promoter Mpz expressing CD63-GFP gene track transport. microRNA (miRNA)...
Background: The aim of the present study was to compare effects drug-eluting stents (DES) and coronary artery bypass grafting (CABG) in patients suffering from chronic stable angina with multivessel disease, involving significant proximal stenosis left anterior descending (LAD). Methods Results: All consecutive disease LAD underwent DES implantation (n=600) or CABG (n=709) at our institution. At 2 years, unadjusted mortality significantly lower group than (2.2% vs 5.2%, P=0.004), but...
Objective To investigate the relationship between lipid profiles [including total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C) and high-density (HDL-C)] a mild decline in estimated glomerular filtration rate (eGFR) subjects with normal serum levels. Design Methods In this study, we included 2647 participants who were ≥40 years old had The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was used to estimate GFR. A mildly reduced eGFR defined as...
Abstract Background Depression in essential tremor (ET) has been constantly studied and reported, while the associated brain activity changes remain unclear. Recently, regional homogeneity (ReHo), a voxel-wise local functional connectivity (FC) analysis of resting-state magnetic resonance imaging, provided promising way to observe spontaneous activity. Methods Local FC analyses were performed forty-one depressed ET patients, 49 non-depressed patients 43 healthy controls (HCs), then matrix...
Red sage, the dry root and rhizome of herbaceous plant Salvia miltiorrhiza Bunge, is widely used for treating various diseases. The low content tanshinones (terpenoids) has always restricted development S. industry. Here, we found that SmDXS5 , a rate-limiting enzyme-coding gene located at intersection primary secondary metabolism, can effectively change transcription level metabolome profile hairy roots significantly increase tanshinones. Agrobacterium rhizogenes was to infuse explants,...