A5100446789- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Urinary and Genital Oncology Studies
- Ferroptosis and cancer prognosis
- Pancreatitis Pathology and Treatment
- TGF-β signaling in diseases
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Nanoparticle-Based Drug Delivery
- Cancer Cells and Metastasis
- Pancreatic function and diabetes
- Rheumatoid Arthritis Research and Therapies
- Cancer, Lipids, and Metabolism
- Peripheral Neuropathies and Disorders
- GDF15 and Related Biomarkers
- Nutrition and Health in Aging
- Cervical and Thoracic Myelopathy
- Metallurgy and Material Forming
- Monoclonal and Polyclonal Antibodies Research
- Renewable Energy and Sustainability
- Ginseng Biological Effects and Applications
Sun Yat-sen University
2023-2025
Chinese University of Hong Kong
2023-2025
Third Affiliated Hospital of Sun Yat-sen University
2023-2025
Fujian Medical University
2021-2024
Union Hospital
2024
Prince of Wales Hospital
2024
Taiyuan Central Hospital
2022
Jilin University
2022
First Hospital of Jilin University
2022
Union Hospital
2022
Human umbilical cord-derived mesenchymal stem cells (hUCMSCs) represent potential therapeutic tools for solid tumors. However, there are numerous inconsistent results regarding the effects of hUCMSCs on tumors, and mechanisms underlying this remain poorly understood. The present study further examined controversial issue by analyzing molecular inhibitory proliferation migration human lung cancer A549 cell line hepatocellular carcinoma (HCC) BEL7402 in vitro. Flow cytometric analysis...
Bladder cancer (BC) is a heterogeneous disease with high recurrence rates and variable treatment responses. To address these clinical challenges, the world's first bladder patient-derived organoids (PDOs) biobank established based on an Asian population. Thirty-six BC-PDOs are generated from 56 patients demonstrated that can replicate histological genomic features of parental tumors. Drug screening tests conducted broad spectrum conventional chemotherapeutic targeted therapy drugs identified...
This study reports a facile approach for the green synthesis of high-performance magnetic resonance/computed tomography (MR/CT) dual-modal imaging nanoprobe. The probe, designated as NPs-TCZ, is synthesized via one-step self-assembly two amphiphilic block copolymers, namely, PEG-DTIPA-TCZ and pal-GGGGHHHHD. NPs-TCZ exhibits high longitudinal relaxivity (9.60 mM–1 s–1) X-ray absorption (58.2 Hu mM–1), well excellent water solubility biocompatibility. MR/CT can synergistically visualize...
This study reports a facile and green synthesis of new multifunctional nanotheranostic probe for the synergistic therapy rheumatoid arthritis (RA) in situ assessment therapeutic response. The is synthesized through one-step self-assembly two exquisitely designed peptide-amphiphilic block copolymers (PEG-DTIPA-KGPLGVRK-MTX Pal-GGGGHHHHD-TCZ) under mild conditions, requiring minimal energy input. resultant demonstrates excellent biocompatibility, water solubility, colloidal stability. It...
Leucine-rich-alpha-2-glycoprotein1 (LRG1) is a new oncogene-related gene, which has been proven important for the development and poor prognosis of human cancers. However, whether it participates in esophageal squamous cell carcinoma (ESCC) progression remains unclear.To investigate expression level functional influence LRG1 ESCC.The was evaluated on mRNA protein ESCC patients. Then, correlation with clinicpathological variables analyzed ESCC. Besides, to clarify biological function LRG1,...
Abstract Background Antioxidase alleviates the accumulation of radiation-induced reactive oxygen species (ROS) and therefore has strong connections with radioresistance. Isocitrate dehydrogenase 2 (IDH2) facilitates turnover antioxidase, but its role in radiotherapeutic efficiency oesophageal squamous cell carcinoma (ESCC) still remains elusive. Methods The involvement IDH2 efficacy ESCC was investigated vitro vivo by knockdown. expression biopsy specimens 141 patients identified to evaluate...
Chronic atrophic gastritis (CAG) is an important stage in the transformation of normal gastric mucosa into cancer. Granule Dendrobii (GD), a proprietary Chinese medicine, has proven clinical efficacy treating CAG. GD might promote reversal precancerous lesions by improving them CAG patients. However, mechanism treatment relatively less understood. Here, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced rats were treated with and its was evaluated observing changes rats' weight pathology...
We aimed to investigate the pattern of expression and clinical significance isocitrate dehydrogenase 1(IDH1) in esophageal squamous cell carcinoma (ESCC). The IDH1 was determined by quantitative real-time polymerase chain reaction, immunohistochemistry, Western blot analysis using 38 pairs frozen tissues. Enzyme-linked immunosorbent assay employed measure 67 serum samples from patients their controls evaluate its diagnostic value. Immunohistochemistry 111 formalin-fixed paraffin embedded...
The WD40 protein family member WD repeat domain 5 (WDR5) plays significant roles in the tumorigenesis and development of multiple organ tumours. However, correlation between WDR5 expression oesophageal squamous cell carcinoma (ESCC) has not been elucidated.WDR5 mRNA data were acquired from Cancer Genome Atlas (TCGA) database, prognostic potential assessed by immunohistochemistry (IHC) Western blot. counting kit-8 (CCK-8), colony formation assay cycle evaluation performed to verify function...
Dendrobium officinale is an herb of Traditional Chinese Medicine (TCM) commonly used for treating stomach diseases. One formula Granule Dendrobii (GD) consists and American Ginseng (Radix Panacis quinquefolii), a potent TCM product in China. Whether treatment with GD can promote gastric acid secretion alleviate gland atrophy chronic atrophic gastritis (CAG) requires verification.To determine the effect on CAG its potential cellular mechanism.A model was induced by feeding rats...
The miRNAs are dysregulated in BPH. Rape bee pollen (RBP) is used to improve benign prostatic hyperplasia (BPH). Whether RBP treats BPH by regulating the remains unclear. Here, we identified regulated along with improvement of posterior lobes prostate rats. Firstly, screened might relate RBP, compared differentially expressed between model group and high-throughput sequencing. As a result, 10 known 17 novel miRNA were up-regulated group, 6 13 down-regulated. Secondly, among miRNAs, those...
Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases occurring during pregnancy. MiR-182-3p participates in a variety physiological processes such as cell proliferation, apoptosis, differentiation, and migration5, but its role GDM largely unknown.To investigate relationship between miRNA-182-3p explore potential therapeutic strategy for GDM.Animal experimentation.To evaluate effect miRNA182-3p GDM, mice were separated negative control (NC), mimic or inhibitor,...
Testosterone propionate-induced benign prostatic hyperplasia in rats is a common model that widely used studies of the effects and molecular mechanisms drugs designed to treat hyperplasia. RT-qPCR technique gene expression studies. Proper normalisation critical for accurate analysis. Currently, no validated reference genes are available rat Given microRNAs regulate mRNA at post-transcriptional level, they usually studied together. Here, stability 21 putative including 8 mRNAs 13 miRNAs was...
The correlation between the expression levels of p65 and TNF-α in patients with acute myelocytic leukemia (AML) AML cell lines were investigated. bone marrow samples 30 10 non‑leukemia controls studied. mRNA TNF‑α detected by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR), Pearson's Correlation test was used to demonstrate TNFα specimens. Receiver operating characteristic (ROC) curves plotted determine whether could be differentiate from samples. MG132 anti‑TNFα...
12-LOX plays an important role in the progression of various malignancies. However, underlying mechanisms action and tumour treatment strategies remain not fully defined. In this study, we investigated possible roles ESCC explored new therapeutic target. Approximately 73% tissues showed marked up-regulation 12-LOX, which was associated with poor prognosis. overexpression positively correlated malignant as demonstrated both vitro vivo. Up-regulation significantly increased proliferation cells...