A5052000524- Head and Neck Cancer Studies
- RNA modifications and cancer
- Optical Network Technologies
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Photonic and Optical Devices
- Cancer Immunotherapy and Biomarkers
- Semiconductor Lasers and Optical Devices
- Lung Cancer Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Advanced Fiber Laser Technologies
- Immune cells in cancer
- Radiomics and Machine Learning in Medical Imaging
- Galectins and Cancer Biology
- Lung Cancer Research Studies
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Advanced Fiber Optic Sensors
- Chemokine receptors and signaling
- Advanced Photonic Communication Systems
- MicroRNA in disease regulation
- PI3K/AKT/mTOR signaling in cancer
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
Second Xiangya Hospital of Central South University
2017-2025
Xiangya Hospital Central South University
2013-2025
Central South University
2013-2024
Temple University
2024
Harvard University
2024
American Academy of Otolaryngology — Head and Neck Surgery
2024
Bloomberg (United States)
2019-2023
Johns Hopkins University
2020-2023
Sidney Kimmel Comprehensive Cancer Center
2019-2023
Johns Hopkins Medicine
2021-2022
The prognosis of head and neck squamous cell carcinoma (HNSCC) patients remains poor.High-throughput sequencing data have laid a solid foundation for identifying genes related to cancer prognosis, but gene marker is needed predict clinical outcomes in HNSCC.In our study, we downloaded RNA Seq, single nucleotide polymorphism, copy number variation, follow-up from TCGA.The samples were randomly divided into training test.In the set, screened used random forests feature selection.Gene-related...
We experimentally demonstrate the concept of simultaneous spatial and temporal focusing femtosecond pulses. Our technique has potential to significantly reduce background excitation which fundamentally limits imaging depth in scattering biological specimens.
Alternatively activated macrophages in tumor microenvironment is defined as M2 tumor-associated (M2 TAMs) that promote cancer progression. However, communicative mechanisms between TAMs and cells squamous cell carcinoma of head neck (SCCHN) remain largely unknown. Quantitative real-time PCR, western blotting, enzyme-linked immunosorbent assay flow cytometry were applied to quantify mRNA protein expression genes related TAMs, epithelial–mesenchymal transition (EMT) stemness. Wounding-healing...
The association between pretreatment nutritional status and immunotherapy response in patients with advanced head neck cancer is unclear. We retrospectively analyzed a cohort of 99 who underwent treatment anti-PD-1 or anti-CTLA-4 antibodies (or both) for stage IV HNSCC 2014 2020 at the Johns Hopkins Hospital. Patient demographics clinical characteristics were retrieved from electronic medical records. Baseline prognostic index (PNI) scores body mass (BMI) trends calculated. Associations PNI...
Metastasis is a major event for survival and prognosis in patients with head neck squamous cell carcinomas (HNSCC). A primary cause of metastasis the proteolytic degradation extracellular matrix (ECM). The plasminogen activator urokinase (PLAU) involved transformation to plasmin leading hydrolyzation ECM-related proteins. However, role PLAU expression HNSCC unclear worth being investigated.PLAU profiles clinical parameters from multiple datasets were used investigate relationship survival....
Three-dimensional (3D) bioprinting is a promising additive manufacturing technology that uses imaging data and computer-assisted deposition of biological materials or cells to reconstruct complex 3D structures accurately. This has progressed rapidly, in part because its integration across multiple disciplines combination with other technologies for clinical applications. Advances experimental research applications related otorhinolaryngology have led the development diagnostic treatment...
Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease characterised by aberrant activation and differentiation of autoreactive T B cells, as well the overproduction autoantibodies. CD6, cell-surface glycoprotein, regulates lymphocyte activation, survival, implicated in pathogenesis various disorders. In SLE, CD6/activated leukocyte cell adhesion molecule (ALCAM) pathway promotes renal T-cell immune responses. However, distribution, expression, function CD6 cells remain...
Abstract Head and neck squamous cell carcinoma (HNSCC) is a common malignant cancer that accounts for 5–10% of all cancers. This study aimed to identify essential genes associated with the prognosis HNSCC construct powerful prognostic model risk assessment HNSCC. RNAseq expression profile data patients were obtained from TCGA database (GEO). A total 500 samples full clinical following-up randomly divided into training set validation set. The was used screen differentially expressed lncRNAs....
Abstract Metastasis is one of the primary causes for high mortality in patients with squamous cell carcinoma head and neck (SCCHN). Our previous study showed that chemokine (C‐C motif) ligand 18 (CCL18), derived from tumour‐associated macrophages (TAMs), regulates SCCHN metastasis by promoting epithelial‐mesenchymal transition (EMT) preserving stemness. However, underlying mechanism needs to be further investigation. Interestingly, metadherin (MTDH) expression was induced when cells were...
All-optical Boolean XOR logic using a differential phase modulation scheme of the semiconductor optical amplifier-based Mach-Zehnder interferometer (SOA-MZI) proposed and experimentally demonstrated. The is tested at 10 Gbit/s with full duty cycle operation. method attractive because speed operation not limited by carrier recovery time SOA.
A multiwavelength fiber laser source is demonstrated with a semiconductor optical amplifier as the gain medium. delayed interferometer incorporated in ring cavity serving comb-like multichannel filter. stable 75-wavelength simultaneous operation spaced at 40 GHz extinction ratio of dB achieved. By tuning loss, center wavelength generated lasing waveband could be varied by much 20 nm.
Abstract Despite progression in advanced treatments for malignant tumors, surgery remains the primary treatment intervention, which removes a large portion of firm tumor tissues; however, postoperative phase poses possible risk provincial recurrence and metastasis. Consequently, prevention metastasis has attracted research attention. In this review, we summarized strategies various tumors from both basic clinical perspectives. We delineated underlying factors contributing to with substantial...
Our previous study indicated overexpression of metadherin (MTDH) is an adverse prognostic factor in squamous cell carcinoma the head and neck (SCCHN) promotes SCCHN proliferation invasion. However, its mechanism remains unclear. Recent studies have that MTDH a cancer-metastasis-associated molecule participates process angiogenesis. Therefore, aimed to investigate whether vascular endothelial growth (VEGF), as one most potent proangiogenic cytokines, regulated by role phosphatidylinositide...
Overexpression of histone demethylase PHF8 has been reported to function as an oncoprotein in many cancers; however, the implications involvement laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC) remain unclear. This study aims explore expression its clinical significance LHSCC. Western blotting immunohistochemistry were performed evaluate protein fresh archived LHSCC samples. Global expressions H3K27 H3K9 methylation analyzed a line with siRNA treatment. In our study, was...