A5090393032- Thyroid Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Cervical Cancer and HPV Research
- Bioinformatics and Genomic Networks
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
- RNA Research and Splicing
- Head and Neck Cancer Studies
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Protist diversity and phylogeny
- Polysaccharides and Plant Cell Walls
- Biomarkers in Disease Mechanisms
- Aluminum toxicity and tolerance in plants and animals
- Thyroid and Parathyroid Surgery
- Synthesis and biological activity
- Chemotherapy-induced organ toxicity mitigation
- Curcumin's Biomedical Applications
- Galectins and Cancer Biology
- NF-κB Signaling Pathways
- Epigenetics and DNA Methylation
Nanchang University
2012-2024
Second Affiliated Hospital of Nanchang University
2012-2024
First Affiliated Hospital of Nanchang University
2020
Central South University
2011-2016
Xiangya Hospital Central South University
2011-2016
The prognosis of head and neck squamous cell carcinoma (HNSCC) patients remains poor.High-throughput sequencing data have laid a solid foundation for identifying genes related to cancer prognosis, but gene marker is needed predict clinical outcomes in HNSCC.In our study, we downloaded RNA Seq, single nucleotide polymorphism, copy number variation, follow-up from TCGA.The samples were randomly divided into training test.In the set, screened used random forests feature selection.Gene-related...
Background The aim was to identify a novel prognostic miRNA signature for colon cancer (CC) in silico. Methods Data on the expression of miRNAs and relevant clinical information 407 patients were obtained from Cancer Genome Atlas (TCGA), samples randomly split into validation set (n = 203) training 204). differential between normal tissues with CC analyzed. We detected dataset by using Cox proportional hazard regression model. Then, we verified set. Association overall survival assessed...
The purpose of this study was to clarify the effect ZC3H13 on growth papillary thyroid carcinoma (PTC).Firstly, we used qRT-PCR and Western blot compare difference in expression between normal epithelial cells PTC cell lines. Then, overexpression/knockout cancer were constructed by lentivirus transfection, effects overexpression proliferation, migration invasion detected CCK8 transwell experiments. Lastly, MeRIP-qPCR, RIP o Actinomycin D verify that regulated downstream target gene IQGAP1...
Abstract Head and neck squamous cell carcinoma (HNSCC) is a common malignant cancer that accounts for 5–10% of all cancers. This study aimed to identify essential genes associated with the prognosis HNSCC construct powerful prognostic model risk assessment HNSCC. RNAseq expression profile data patients were obtained from TCGA database (GEO). A total 500 samples full clinical following-up randomly divided into training set validation set. The was used screen differentially expressed lncRNAs....
BACKGROUND: Long non-coding RNAs (lncRNAs) were recently identified as crucial regulators of papillary thyroid cancer (PTC). However, the clinical role and regulatory functions lncRNA susceptibility candidate 2 (CASC2) in PTC remain unknown
At present, the risk factors of cervical lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC) are still controversial. This study was aimed to investigate various types LNM PTC with tumor diameter>1 cm. The clinical data 2216 patients were retrospectively analyzed. Univariate and multivariate logistic regression models used analyze LNM. In addition, receiver operator characteristic (ROC) curve find best cut-off value CLNM for predicting LLNM. Finally, independent LLNM construct...
Background The overall prevalence of papillary thyroid carcinoma (PTC) patients is expanding along with an ongoing increase in cancer incidence. Patients PTC who have lymph node metastases a poor prognosis and high death rate. There urgent need for indicators that can predict metastasis (LNM) before surgery as current imaging techniques, such ultrasonography, do not sufficient sensitivity to detect LNM. To independent risk factors Central (CLNM) or Lateral (LLNM), we therefore developed two...
This study evaluated the predictive value of preoperative albumin/globulin ratio (AGR) in laryngeal squamous cell carcinoma (LSCC) retrospectively, which has not been reported before. The current enrolled 241 newly diagnosed LSCC patients Second Affiliated Hospital Nanchang University between January 2005 and December 2010. optimal AGR cut-off for overall survival (OS) was determined to be 1.28. Univariate analysis identified sex, low AGR, T classification, histological grade nodal...
The objective of this study was to examine the in vitro combinatorial anticancer effects curcumin and sorafenib towards thyroid cancer cells FTC133 using a MTT cytotoxicity assay, test whether mechanism involves induction apoptosis. present results demonstrated that at 15–25 μM dose-dependently suppressed proliferation FTC133. Combined treatment (curcumin (25 μM) (2 μM)) resulted reduction cell colony formation significantly decreased invasion migration compared with treated individual...
Background Anaplastic thyroid cancer (ATC) is highly invasive, prone to distant metastasis (DM), and has a very poor prognosis. This study aims construct an accurate survival prediction model for ATC patients with DM, providing reference comprehensive assessment treatment planning. Methods We extracted data of DM diagnosed between 2004 2019 from the SEER database, randomly dividing them into training set validation in ratio 7:3. Univariate multivariate Cox regression analyses were...
Summary Background Proteomics tools can be used to identify the differentially expressed proteins related allergic rhinitis ( AR ). However, large numbers of have not yet been explored using an advanced quantitative proteomics approach, known as isobaric tags for relative and absolute quantitation iTRAQ Objectives To in persistent patients explore regulatory signalling pathways involving identified proteins. Methods Forty‐five 20 healthy controls were recruited this study. was that between...
Cancer stem cells (CSCs) have been characterized by several exclusive features that include differentiation, self-renew, and homeostatic control, which allows tumor maintenance spread. Recurrence therapeutic resistance of head neck squamous cell carcinomas (HNSCC) identified to be attributed CSCs. However, the biomarkers led development HNSCC remain less defined. In this study, we quantified cancer stemness mRNA expression-based index (mRNAsi), found mRNAsi indices were higher in tissues...
Background Most head and neck squamous cell carcinoma (HNSCC) patients are diagnosed at an advanced local stage. While immunotherapy has improved survival rates, only a minority of respond durably to targeted immunotherapies, posing substantial clinical challenges. We investigated the heterogeneity tumor microenvironment in HNSCC cohorts before after by analyzing single-cell RNA sequencing (scRNA-seq) data bulk datasets retrieved from public databases. Methods constructed transcriptome...
Papillary thyroid carcinoma (PTC) is the most common malignancy in tissue, and number of patients with PTC has been increasing recent years. Discovering mechanism genesis progression finding new potential diagnostic biomarkers/therapeutic target genes are great significance.In this work, datasets GSE3467 GSE3678 were downloaded from Gene Expression Omnibus (GEO) database. Differentially expressed (DEGs) identified limma package R. GO function KEGG pathway enrichment conducted DAVID tool. The...
The present study was to identify and quantitate differentially expressed proteins in laryngeal squamous cell carcinoma (LSCC) tissues with or without lymph node metastasis explore transcriptional factors regulation networks associated the process. Tissue specimens were taken from 20 patients LSCC, including 10 cases of LSCC (N0) (Nx). Among 643 unique identified by using iTRAQ labeling quantitative proteomic technology, 389 showed an abundance change (Nx) as compared (N0). Cytoskeleton...
The prognosis of most patients with papillary thyroid carcinoma (PTC) is excellent despite some cases tumor progression or relapse. present study was designed to reveal possible prognostic risk indicators for PTC. Differentially expressed genes (DEGs) extracted from 4 Gene Expression Omnibus (GEO) cohorts were subjected functional enrichment analyses by Ontology (GO) and Kyoto Encyclopedia Genes Genome (KEGG) pathway analysis. A dataset Cancer Atlas (TCGA) obtained filter validate...
Ferroptosis is that under the action of ferrous iron or ester oxygenase, unsaturated fatty acids highly expressed on cell membrane are catalyzed to undergo lipid peroxidation, thereby inducing death. In this study, we used ferroptosis marker genes identify 3 stable molecular subtypes (C1, C2, C3) with distinct prognostic, mutational, and immune signatures by consensus clustering; TP53, CDKN2A, etc. Have higher mutation frequencies in three subtypes. C3 has a better prognosis, while C1...
Alternative splicing (AS) is an important mechanism responsible for the production of protein diversity. Increasing evidence has suggested that out-of-control alternative closely related to genesis and development cancer. Genome-wide analysis on head neck squamous cell carcinoma (HNSCC) not been systemically studied, so remains at preliminary stage requires further studies by researchers. In this study, systemic bioinformatic was carried out genome-wide events 498 clinical HNSCC samples from...