A5060287760- Thyroid Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Breast Lesions and Carcinomas
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Cancer Studies
- Cancer-related Molecular Pathways
- Cancer Risks and Factors
- Microtubule and mitosis dynamics
- Thyroid and Parathyroid Surgery
- Breast Implant and Reconstruction
- ATP Synthase and ATPases Research
- Supramolecular Self-Assembly in Materials
- Peroxisome Proliferator-Activated Receptors
- Neuroendocrine Tumor Research Advances
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Biomedical Text Mining and Ontologies
- MRI in cancer diagnosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Parathyroid Disorders and Treatments
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
Nanchang University
2013-2024
Changchun University of Chinese Medicine
2024
Second Affiliated Hospital of Nanchang University
2013-2023
Nanjing General Hospital of Nanjing Military Command
2013
General Hospital of Jinan Military Command
2013
Although increasing evidence has demonstrated important roles for long non-coding RNAs (lncRNAs) in cancer development, their functions oral squamous cell carcinoma (OSCC) growth remain largely unknown. Therefore, we aimed to investigate the role of LINC00662 OSCC.The expression 61 OSCC tissues and four lines were detected by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Cell proliferation was using Counting Kit-8 (CCK-8) EdU staining methods. Migration invasion...
Background: Androgenic alopecia (AGA) is a common condition influenced by genetic and hormonal factors, with emerging evidence linking it to gut microbiota. Dysbiosis may affect AGA through immune regulation, androgen metabolism, systemic pathways. Using Mendelian randomization (MR), this study investigates the causal relationship between microbiota AGA, aiming uncover potential mechanisms therapeutic targets. Methods: The selected six types of microbiota-related loci associated GM from...
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive malignancies, frequently accompanied by metastasis and aerobic glycolysis. Cancer cells adjust their metabolism modulating PKM alternative splicing facilitating PKM2 isoform expression. Therefore, identifying factors mechanisms that control significant for overcoming current challenges in ATC treatment.In this study, expression RBX1 was largely enhanced tissues. Our clinical tests suggested high significantly related to poor...
This study evaluated the predictive value of preoperative albumin/globulin ratio (AGR) in laryngeal squamous cell carcinoma (LSCC) retrospectively, which has not been reported before. The current enrolled 241 newly diagnosed LSCC patients Second Affiliated Hospital Nanchang University between January 2005 and December 2010. optimal AGR cut-off for overall survival (OS) was determined to be 1.28. Univariate analysis identified sex, low AGR, T classification, histological grade nodal...
Abstract Background The study was designed to explore the regular patterns of level V lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC), and indicate whether should be included management lateral neck dissection when treating PTC. Methods This retrospective consisted 330 patients diagnosed with PTC from January 1994 July 2009 who underwent an operation that therapeutic (levels II V). LNM were analyzed relevant risk factors univariate multivariate analysis, respectively....
Objectives . The aim of the present study was to analyze association between pretreatment body mass index (BMI) and aggressiveness papillary thyroid carcinoma (PTC) along with its clinical outcomes in a Chinese population BMI classification for Asians. Methods A retrospective, observational conducted on patients from two teaching hospitals China. 1622 classical PTC were categorized into four groups according BMI. Results We found that increased associated extrathyroidal extension,...
Cholangiocarcinoma (CCA) is a common malignancy of the digestive system, and its treatment greatly challenged by rising chemoresistance. Long non-coding RNAs (lncRNAs) have been shown to play critical roles in development drug resistance tumors. However, role lncRNA CCAT1 erlotinib CCA remains unclear. In this investigation, we identified as pivotal factor contributing CCA. Furthermore, uncovered that modulated epithelial-mesenchymal transition (EMT) through Rho-associated...
Papillary thyroid carcinoma (PTC) is the most common malignancy in tissue, and number of patients with PTC has been increasing recent years. Discovering mechanism genesis progression finding new potential diagnostic biomarkers/therapeutic target genes are great significance.In this work, datasets GSE3467 GSE3678 were downloaded from Gene Expression Omnibus (GEO) database. Differentially expressed (DEGs) identified limma package R. GO function KEGG pathway enrichment conducted DAVID tool. The...
Long non-coding RNAs (lncRNAs) have been widely reported that involved in human cancers, including papillary thyroid carcinoma (PTC). The present study aims to investigate the biological role of LINC00982 PTC. mRNA expression PTC tissues was detected using qPCR. Moreover, Kaplan-Meier method performed analyze internal relevance between and overall survival (OS) rate patients with In addition, gain- loss-of-functions assays were detect effects on cell proliferation migration cells....
Background: Papillary thyroid carcinoma (PTC) is the most prevalent cancer type in endocrine system. Metastases to parapharyngeal lymph nodes (PPLNs) are rare. Herein, we reported a case series of PTC patients with PPLN metastases operated on by using minimally invasive video-assisted (MIVA) technique evaluate safety and effectiveness this technique. Method: In single-institutional study, six consecutive between January 2012 July 2018 were enrolled. All PPLNs managed MIVA Result: Six (three...
The galectin 2 (LGALS2) protein has been shown to be associated with the pathogenic progression of a range cancer types, yet its role in papillary thyroid carcinoma (PTC) remains poorly defined. Accordingly, present study was conducted address this gap literature.Eighty pairs tumor and paracancerous tissues from PTC patients were collected. Western immunoblotting real-time quantitative polymerase chain reaction (qPCR) used compare LGALS2 expression levels patients. An overexpression...
Background: The sentinel lymph node biopsy is an alternative to axillary dissection for many breast cancer patients. Cases of anaphylactic reaction the isosulfan blue dye used during have recently been reported. To prospectively reduce incidence and severity adverse reactions dye, we evaluated severe performance at our institution. Methods: A retrospective chart review study enrolled 1,456 consecutive patients with Sentinel was performed using both technetium-99m sulfur colloid. anaphylaxis...
Educational attainment (EA) is often used as a symbol of socioeconomic status and associated with several diseases. However, uncertainty remains regarding the potential relationship between EA chronic pain. This study aimed to evaluate causal association The primary method employed in Mendelian randomization (MR) analysis was inverse-variance weighted method. Additionally, MR-Egger intercept, Cochran Q , MR-PRESSO statistical analyses were conducted assess pleiotropy heterogeneity. MR...
Abstract Background: The disruption of tumour cell metabolism can inhibit metastasis, indicating that aerobic glycolysis is central to development. However, the key factors responsible for mediating in hepatocellular carcinoma (HCC) remain unknown. Methods: This study investigated function and clinical significance RBCK1 protein expression HCC. We analyzed from TCGA-LIHC dataset surgical specimens 216 HCC patients. correlation between characteristics prognosis was also determined....