A5101423102- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Circular RNAs in diseases
- Angiogenesis and VEGF in Cancer
- Ferroptosis and cancer prognosis
- RNA Interference and Gene Delivery
- Folate and B Vitamins Research
- Histone Deacetylase Inhibitors Research
- Chronic Disease Management Strategies
- Kruppel-like factors research
- Electron Spin Resonance Studies
- FOXO transcription factor regulation
- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- Social and Behavioral Studies
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Immune cells in cancer
- Advanced Drug Delivery Systems
- Monoclonal and Polyclonal Antibodies Research
- Oral Health Pathology and Treatment
- Inflammasome and immune disorders
Nanchang University
2018-2025
Second Affiliated Hospital of Nanchang University
2021-2025
Anhui University of Traditional Chinese Medicine
2024
First Affiliated Hospital of Nanchang University
2018-2024
Sichuan University
2016-2023
State Key Laboratory of Oral Diseases
2023
First Affiliated Hospital of Jiangxi Medical College
2023
Shanghai Institute of Materia Medica
2018-2020
Chinese Academy of Sciences
2018-2020
Guangxi University
2019
Inflammatory bowel diseases (IBD) are the incurable chronic recurrent gastrointestinal disorders and currently lack in safe effective drugs. In this study, patchouli alcohol, a main active compound of traditional Chinese herb patchouli, was developed into biomimetic liposomes for macrophage-targeting delivery IBD treatment. The lactoferrin-modified (LF-lipo) can specifically bind to LRP-1 expressed on activated colonic macrophages achieve cell-targeting anti-inflammatory therapy. LF-lipo...
Antibody drug conjugates (ADCs) have shown promise to be the mainstream chemotherapeutics for advanced HER2-positive cancers, yet issues of poor delivery efficiency, limited chemotherapeutic effects, severe immune responses, and resistance remain addressed before clinical applications ADCs. The DNA aptamer-guided (ApDCs) are receiving growing attention specific tumors due their excellent tumor affinity low cost. Therefore, developing a multivalent ApDC nanomedicine by combining anti-HER2...
It has been shown that ferroptosis is involved in doxorubicin (DOX)‑induced cardiotoxicity and ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) can protect cardiomyocytes from ferroptosis. Thus, the present study aimed to investigate whether ENPP2 could DOX‑induced injury by inhibiting H9c2 were exposed various concentrations (0.625, 1.25, 2.5, 5 or 10 <em>µ</em>M) of DOX for different time periods. Cell viability expression determined. ENPP2‑overexpressing cells treated with...
Tumor metastasis would seriously impair the efficacy of chemotherapy. Our previous studies showed losartan combined with paclitaxel-loaded pH-sensitive cleavable liposomes (PTX-Cl-Lip) facilitated paclitaxel accumulation and led to enhanced antitumor in 4T1 bearing mice. Since could inhibit level collagen I which was related tumor metastasis, this strategy further applied suppress time. vivo anti-metastatic study manifested lower colonies occupied lungs by 76.4% compared that saline group....
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive malignancies, frequently accompanied by metastasis and aerobic glycolysis. Cancer cells adjust their metabolism modulating PKM alternative splicing facilitating PKM2 isoform expression. Therefore, identifying factors mechanisms that control significant for overcoming current challenges in ATC treatment.In this study, expression RBX1 was largely enhanced tissues. Our clinical tests suggested high significantly related to poor...
Periodontitis, a common dental illness, causes periodontal tissue inflammation and irreversible bone loss, inevitably resulting in tooth loss. Hyperhomocysteinaemia (HHcy), defined as blood total homocysteine (Hcy) levels greater than 15 µmol/L, is linked to increased cardiovascular disease risk. Mounting evidence indicates connection between HHcy periodontitis; however, the underlying processes remain unknown. Herein, we explored mechanisms by which exacerbates osteoclast formation. In an...
Self-nanoemulsifying systems (SNEs) have excellent ability to improve the solubility of poorly water-soluble drugs (PWSD). However, SNEs are likely be degraded in gastrointestinal (GIT) when their surface is recognized by lipase/co-lipase enzyme complex, resulting rapid release and precipitation encapsulated drugs. The precipitates then captured removed intestinal mucus, reducing delivery efficacy SNEs. Herein, amphiphilic polymer Pluronic® F127 was incorporated into long short-chain...
Early transcription factors play critical roles in the development of acute lung injury/acute respiratory distress syndrome (ALI/ARDS). growth response 1 (EGR1) is a factor essential for various biological processes, including regulation metabolism, differentiation, and inflammation. However, its role ALI has been poorly reported. In this study, we aimed to determine effect EGR1 on gain insights into theoretical basis further treatment ALI. By employing concerted molecular biology...
Triple-negative breast cancer (TNBC) patients are at high risk of recurrence and metastasis in the early stages, although receiving standard treatment. However, underlying mechanism TNBC remains unclear. Here, critical effect E3 ubiquitin ligase RBX1 was reported for first time. We discovered that expression evidently raised tissues TNBC. Our clinical research displayed markedly related to poor distant invasion survival. Functional analysis exhibited facilitated cells through increasing EMT....
Objective To investigate the risk factors of all-cause mortality in diabetic patients on peritoneal dialysis (PD). Methods As a single-center retrospective cohort study, all incident PD who were catheterized at First Affiliated Hospital Nanchang University between November 1, 2005 and February 28, 2017 included. Patients divided into diabetes mellitus group (DM group) non-diabetes (NDM group). Outcomes analyzed by Kaplan-Meier method. Multivariate Cox proportional hazards models...