A5100425706- Single-cell and spatial transcriptomics
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- RNA Interference and Gene Delivery
- Immune cells in cancer
- RNA modifications and cancer
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Oral microbiology and periodontitis research
- Cancer, Lipids, and Metabolism
- Phytochemical Studies and Bioactivities
- Epigenetics and DNA Methylation
- Natural product bioactivities and synthesis
- Gene expression and cancer classification
- SARS-CoV-2 and COVID-19 Research
- Periodontal Regeneration and Treatments
- Nuclear Receptors and Signaling
- Asthma and respiratory diseases
- Cancer Immunotherapy and Biomarkers
- Cell Image Analysis Techniques
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Genomics, phytochemicals, and oxidative stress
Sichuan University
2015-2025
West China Hospital of Sichuan University
2019-2025
Shanxi Agricultural University
2021-2025
Chinese Institute for Brain Research
2021-2025
Huazhong University of Science and Technology
2023-2025
Tongji Hospital
2023-2025
Tianjin Medical University
2021-2024
Institute of Hematology & Blood Diseases Hospital
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
University of California, San Francisco
2021-2024
Abstract A thorough interrogation of the immune landscape is crucial for immunotherapy strategy selection and prediction clinical responses in non-small-cell lung cancer (NSCLC) patients. Single-cell RNA sequencing (scRNA-seq) techniques have prompted opportunity to dissect distinct signatures between adenocarcinoma (LUAD) squamous cell carcinoma (LUSC), two major subtypes NSCLC. Here, we performed scRNA-seq on 72,475 cells from 40 samples tumor matched adjacent normal tissues spanning 19...
Abstract Lung adenocarcinomas (LUAD) arise from precancerous lesions such as atypical adenomatous hyperplasia, which progress into adenocarcinoma in situ and minimally invasive adenocarcinoma, then finally adenocarcinoma. The cellular heterogeneity molecular events underlying this stepwise progression remain unclear. In study, we perform single-cell RNA sequencing of 268,471 cells collected 25 patients four histologic stages LUAD compare them to normal cell types. We detect a group closely...
Cell penetrating peptides (CPPs) were widely used for drug delivery to tumor. However, the nonselective in vivo penetration greatly limited application of CPPs-mediated systems. And treatment malignant tumors is usually followed by poor prognosis and relapse due existence extravascular core regions Thus it important endue selective targeting stronger intratumoral diffusion abilities CPPs. In this study, an RGD reverse sequence dGR was conjugated a CPP octa-arginine form CendR (R/KXXR/K)...
Abstract Lung adenocarcinoma (LUAD) and squamous carcinoma (LUSC) are two major subtypes of non-small cell lung cancer with distinct pathologic features treatment paradigms. The heterogeneity can be attributed to genetic, transcriptional, epigenetic parameters. Here, we established a multi-omics atlas, integrating 52 single-cell RNA sequencing 2342 public bulk sequencing. We investigated their differences in genetic amplification, cellular compositions, expression modules. revealed that LUAD...
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs) and CRISPR-associated (Cas) proteins serve as an adaptive immune system that safeguards prokaryotes some of the viruses infect from foreign nucleic acids (such plasmids). The genomes majority archaea about half all bacteria contain various CRISPR-Cas systems. systems depend on CRISPR RNAs (crRNAs). They act a navigation to specifically cut destroy by recognizing invading binding Cas proteins. In this review, we provide brief...
Abstract The virulent bacteria‐induced host immune response dominates the occurrence and progression of periodontal diseases because roles individual virulence factors from these pathogens in initiation spread inflammation. Outer membrane vesicles (OMVs) as a pathogenic entity have recently attracted great attention messenger bridges between bacteria tissues. Herein, novel role OMVs derived Fusobacterium nucleatum periodontitis is dissected. In rat model, it found that F. caused...
c-Jun N-terminal kinase (JNK) plays a key role in the regulation of neuronal apoptosis. Previous studies have revealed that forkhead transcription factor (FOXO3a) is critical effector JNK-mediated tumor suppression. However, it not clear whether JNK/FOXO3a pathway involved apoptosis developing rat brain after hypoxia-ischemia (HI). In this study, we generated an HI model using postnatal day 7 rats. Fluorescence immunolabeling and Western blot assays were used to detect distribution...
Lymphocytes and neutrophils are involved in the immune response against cancer. This study aimed to investigate relationship between lymphocyte percentage/neutrophil percentage clinical characteristics of lung cancer patients, explore whether they could act as valuable predictors ameliorate prognosis. A total 1312 patients were eligible be recruited. Lymphocyte neutrophil classified based on their reference ranges. Survival curves determined using Kaplan-Meier method, univariate multivariate...
The interaction between bacteria and the host plays a vital role in initiation progression of systemic diseases, including gastrointestinal oral due to secretion various virulence factors from these pathogens. GroEL, potent factor secreted by multiple pathogenic bacteria, is implicated damage gingival epithelium, periodontal ligament, alveolar bone other peripheral tissues. However, underlying biomechanism still largely unknown. In present study, we verify that GroEL can trigger activation...
Background Among the conservative treatments for rehabilitation of adolescent idiopathic scoliosis (AIS), exercise therapy has attracted a large number studies as its advantages good clinical effect, high operability, compliance, few side effects and low cost. We conduct bibliometric analysis previous research to identify prevalent areas study inform future directions in this paper. Methods Relevant publications reviews were collected using Science Citation Index Expanded from Web Core...