A5003742609- Numerical methods in engineering
- Peptidase Inhibition and Analysis
- Metal Forming Simulation Techniques
- RNA modifications and cancer
- Advanced Fiber Laser Technologies
- Optical Network Technologies
- Chaos-based Image/Signal Encryption
- Photonic Crystal and Fiber Optics
- IL-33, ST2, and ILC Pathways
- Electromagnetic Simulation and Numerical Methods
- Metallurgy and Material Forming
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Advanced Fiber Optic Sensors
- Advanced Numerical Methods in Computational Mathematics
- Web Data Mining and Analysis
- Immune cells in cancer
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Laser and Thermal Forming Techniques
- Galectins and Cancer Biology
- Chemokine receptors and signaling
- Eosinophilic Esophagitis
- Advanced Steganography and Watermarking Techniques
Xiangya Hospital Central South University
2014-2024
Central South University
2014-2024
The University of Texas Health Science Center at San Antonio
2019-2024
Heilongjiang University of Science and Technology
2011-2024
Hunan Provincial Center for Disease Control and Prevention
2021-2024
National Clinical Research Center for Digestive Diseases
2024
Hunan University
2017-2023
Harbin Engineering University
2022-2023
Hangzhou Normal University
2014-2023
Hunan Provincial Science and Technology Department
2023
Alternatively activated macrophages in tumor microenvironment is defined as M2 tumor-associated (M2 TAMs) that promote cancer progression. However, communicative mechanisms between TAMs and cells squamous cell carcinoma of head neck (SCCHN) remain largely unknown. Quantitative real-time PCR, western blotting, enzyme-linked immunosorbent assay flow cytometry were applied to quantify mRNA protein expression genes related TAMs, epithelial–mesenchymal transition (EMT) stemness. Wounding-healing...
Metastasis is a major event for survival and prognosis in patients with head neck squamous cell carcinomas (HNSCC). A primary cause of metastasis the proteolytic degradation extracellular matrix (ECM). The plasminogen activator urokinase (PLAU) involved transformation to plasmin leading hydrolyzation ECM-related proteins. However, role PLAU expression HNSCC unclear worth being investigated.PLAU profiles clinical parameters from multiple datasets were used investigate relationship survival....
Paclitaxel chemoresistance restricts the therapeutic efficacy and prognosis of patients with nasopharyngeal carcinoma (NPC). Accumulating evidence suggests that aberrant expression long non-coding RNAs (lncRNAs) contributes to cancer progression. Therefore, we aimed identify lncRNAs associated paclitaxel resistance in NPC. First, paclitaxel-resistant CNE-2 cells (CNE-2-Pr) were successfully established confirmed be 33.26±8.70 times more resistant than parental cells. Then, differential...
Abstract Metastasis is one of the primary causes for high mortality in patients with squamous cell carcinoma head and neck (SCCHN). Our previous study showed that chemokine (C‐C motif) ligand 18 (CCL18), derived from tumour‐associated macrophages (TAMs), regulates SCCHN metastasis by promoting epithelial‐mesenchymal transition (EMT) preserving stemness. However, underlying mechanism needs to be further investigation. Interestingly, metadherin (MTDH) expression was induced when cells were...
Abstract Licorice, a traditional Chinese medicine, has been widely used for the treatment of COVID-19, but all active compounds and corresponding targets are still not clear. Therefore, this study proposed deep learning-based network pharmacology approach to identify more potential licorice. 4 (quercetin, naringenin, liquiritigenin, licoisoflavanone), 2 (SYK JAK2) relevant pathways (P53, cAMP, NF-kB) were predicted, which confirmed by previous studies be associated with SARS-CoV-2-infection....
Previous studies have indicated that empathic traits, such as perspective taking, are associated with the levels of serotonin in brain and autism spectrum conditions. Inspired by finding receptor 2A gene (HTR2A) modulates availability serotonin, this study investigated to what extent HTR2A individuals' taking ability autistic-like traits. To examine associations functional polymorphism T102C (rs6313) abilities we differentiated individuals according measured traits Interpersonal Reactivity...
Dopamine beta-hydroxylase (DBH), an enzyme that converts dopamine to norepinephrine, has broad influences on social functions. In this study, we examined what extent two polymorphisms (-1021C/T and a 19 bp insertion/deletion) in DBH gene modulate individuals' empathic perception response, which were measured, respectively, by reading the mind eyes test concern subscale of interpersonal reactivity index. Results showed polymorphism at -1021C/T, but not insertion/deletion, accounts for 2.3%...
Our previous study indicated overexpression of metadherin (MTDH) is an adverse prognostic factor in squamous cell carcinoma the head and neck (SCCHN) promotes SCCHN proliferation invasion. However, its mechanism remains unclear. Recent studies have that MTDH a cancer-metastasis-associated molecule participates process angiogenesis. Therefore, aimed to investigate whether vascular endothelial growth (VEGF), as one most potent proangiogenic cytokines, regulated by role phosphatidylinositide...
2'3'-cGAMP is known as a nonclassical second messenger and small immune modulator that possesses potent antitumor antiviral activities via inducing the stimulator of IFN genes-mediated (STING-mediated) signaling pathway. However, its function in regulating type 2 responses remains unknown. Therefore, we sought to determine role STING activation by inflammatory reactions multiple mouse models eosinophilic asthma. We discovered administration strongly attenuated lung immunopathology airway...
<b>Objective</b> To compare outcomes between adjustable spectacles and conventional methods for refraction in young people. <b>Design</b> Cross sectional study. <b>Setting</b> Rural southern China. <b>Participants</b> 648 people aged 12-18 (mean 14.9 (SD 0.98)), with uncorrected visual acuity ≤6/12 either eye. <b>Interventions</b> All participants underwent self without cycloplegia (paralysis of near focusing ability topical eye drops), automated cycloplegia, subjective by an ophthalmologist...
Overexpression of histone demethylase PHF8 has been reported to function as an oncoprotein in many cancers; however, the implications involvement laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC) remain unclear. This study aims explore expression its clinical significance LHSCC. Western blotting immunohistochemistry were performed evaluate protein fresh archived LHSCC samples. Global expressions H3K27 H3K9 methylation analyzed a line with siRNA treatment. In our study, was...
Long non-coding RNAs (lncRNAs) are potentially critical regulators of cancer malignant behaviours.Aberrant expression and dysfunction lncRNA PVT1 have been reported in multiple human cancers.However, its role squamous cell carcinoma the head neck (SCCHN) remains largely unknown.Our current study demonstrated that was increased SCCHN.High positively correlated with SCCHN clinical parameters including T classification, stages cervical lymph node metastasis.More importantly, high predicted a...