A5101973412- Computational Drug Discovery Methods
- Traditional Chinese Medicine Analysis
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
- Coronary Interventions and Diagnostics
- Cancer-related Molecular Pathways
- Phytochemistry and Bioactivity Studies
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Acute Myocardial Infarction Research
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Nerve injury and regeneration
- S100 Proteins and Annexins
- Calpain Protease Function and Regulation
- Botulinum Toxin and Related Neurological Disorders
- COVID-19 Clinical Research Studies
- Circular RNAs in diseases
- Cardiac Ischemia and Reperfusion
- Mesenchymal stem cell research
- Ferroptosis and cancer prognosis
- Neurological Disease Mechanisms and Treatments
- Polysaccharides and Plant Cell Walls
- Chromatography in Natural Products
- SARS-CoV-2 detection and testing
Hangzhou Normal University
2013-2024
Wenzhou Medical University
2020
Wenzhou Hospital of Traditional Chinese Medicine
2014-2017
Alibaba Group (China)
2015
Huangshan University
2011
Ningbo University
2009
UPMC Hillman Cancer Center
1998
In this study, porous gelatin microspheres (GMSs) were constructed to improve the neuroprotective effect of basic fibroblast growth factor (bFGF) on spinal cord injury. GMSs prepared by a W/O emulsion template, followed cross-linking, washing and drying. The particle sizes surface porosity blank carefully characterized scan electronic microscopy. have mean size 35μm theirs was coarse porous. bFGF easily encapsulated inside bulk through diffusion along channel. 200μg completely in 100mg GMSs....
Abstract Licorice, a traditional Chinese medicine, has been widely used for the treatment of COVID-19, but all active compounds and corresponding targets are still not clear. Therefore, this study proposed deep learning-based network pharmacology approach to identify more potential licorice. 4 (quercetin, naringenin, liquiritigenin, licoisoflavanone), 2 (SYK JAK2) relevant pathways (P53, cAMP, NF-kB) were predicted, which confirmed by previous studies be associated with SARS-CoV-2-infection....
Myocardial ischemia-reperfusion injury (MIRI) is a common complication of acute myocardial infarction that seriously endangers human health. Cinnamon, traditional Chinese medicine, has been used to counteract MIRI as it shown possess anti-inflammatory and antioxidant properties. To investigate the mechanisms action cinnamon in treatment MIRI, deep learning-based network pharmacology method was established predict potential active compounds targets. The results showed oleic acid, palmitic...
Abstract A miniaturized solid‐phase method was proposed for the extraction of aflatoxin M1 and B1 from milk jujube samples. Target analytes were identified by ultra high performance liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry in positive mode. The main factors that affected ability sensitivity analytical evaluated detail. In optimal conditions, 30 mg silica particles functionalized octadecyltrimethoxysilane methanol used as sorbent desorption solvent...
Biological and pharmacological activities of dryocrassin ABBA, a phloroglucinol derivative extracted from Dryopteris crassirhizoma, have attracted attention. In this study, the apoptotic effect ABBA on human hepatocellular carcinoma HepG2 cells was investigated.We tested effects in vitro by MTT, flow cytometry, real-time PCR, Western blotting. KM male mice were used to detect H22 vivo.Dryocrassin inhibited growth concentration-dependent manner. After treatment with 25, 50, 75 μg/mL cell...
The Mobile Internet is an integrated product of the traditional internet and mobile communications, represents one most rapidly growing IT fields for current a long period time.However, data show that global still in its infancy, there exist many problems to be solved clarified.This paper first outlines basic concept internet, including definition, features, architecture.Then, based on architecture, we discussed detail research status, problems, solutions various components, terminals,...
A typical traditional Chinese medicine (TCM) prescription (or formula) is composed of one or more kinds herbs, which can play a certain role according to the appropriate dosage and production method. The number possible TCM nearly as large that chemical structures, so development quantitative prescription-efficacy relationship models appealing build structure-efficacy model. In this paper, we first construct binary network prescriptions herbs based on real data. Through analysis network,...
Abstract Licorice, a traditional Chinese medicine, has been widely used for the treatment of COVID-19, but all active compounds and corresponding targets are still not clear. Therefore, this study proposed deep learning-based network pharmacology approach to identify more potential licorice collect information regarding different representative compounds. A graph convolutional neural was construct molecular map develop Morgan fingerprint. Twenty core 6 were predicted, among which 4...
<h3>Aim</h3> To analyse the causes and treatments of no-reflow in percutaneous transluminal coronary intervention acute syndrome patients. <h3>Methods</h3> Reviewed 68 patients who undergo during June 2008 to July 2010 our hospital. The possible reasons, treatment outcome immediately or discharged time were observed. <h3>Results</h3> In all patients, was occurred six cases. One case dead carcinogenic shock at 24 h post therapy,. symptoms as chest distress pain improved flow from TIMI 1 3...
ObjectiveBreast cancer is one of the most prevalent cancers in females worldwide and leading causes death disability women. Multiple therapies have been applied to breast treatment; however, long-term survival rate remains low. Although cisplatin has widely utilized for therapy, chemoresistance still influences outcome.MethodsAfter collecting cell line MDA-MB-231 treated with or without sample information from The Cancer Genome Atlas Program (TCGA), we screened out their common parameters on...
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread worldwide. Reports about the profile of SARS-CoV-2 viral load and serological responses are limited even in relatively short periods. We aimed to investigate profiles RNA, IgM, IgG patients with pneumonia an 8-week period. Methods: A cohort 33 confirmed admitted Wenzhou Sixth People's Hospital from January 27 February 13, 2020, were enrolled this study. Samples throat swab, sputum, stool, blood...
The mechanism of action protein-protein interactions(PPIs) is complex, and prediction models have to learn multiple dimensions achieve excellent generalization performance. Therefore, based on the concept that spatial structure proteins closely related protein functions topological information PPI networks reflects correlation between proteins, we combine enhance We present a new approach, SE3NET-PPI, for multi-type prediction, retrieves from SE (3)-invariant matrix map generated by...