A5091268114- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Renal cell carcinoma treatment
- Renal and related cancers
- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
- RNA modifications and cancer
- High-Energy Particle Collisions Research
- Particle physics theoretical and experimental studies
- Adrenal and Paraganglionic Tumors
- Urinary and Genital Oncology Studies
- Advanced Measurement and Metrology Techniques
- Ovarian cancer diagnosis and treatment
- Quantum Chromodynamics and Particle Interactions
- Urologic and reproductive health conditions
- Testicular diseases and treatments
- Cancer, Hypoxia, and Metabolism
- Urological Disorders and Treatments
- Hormonal Regulation and Hypertension
- Epigenetics and DNA Methylation
- Neuroendocrine Tumor Research Advances
- Advanced Surface Polishing Techniques
- Urinary Bladder and Prostate Research
- Glioma Diagnosis and Treatment
Peking University Shenzhen Hospital
2016-2025
University of Hong Kong - Shenzhen Hospital
2012-2025
Hong Kong University of Science and Technology
2009-2024
University of Hong Kong
2009-2024
Shantou University
2014-2024
Anhui Medical University
2018-2024
Shantou University Medical College
2020-2024
Peking University
2007-2023
University of Maryland, College Park
2023
Merck & Co., Inc., Rahway, NJ, USA (United States)
2023
Increasing evidence has demonstrated that microRNA (miRNA) serve an important role in the tumorigenesis of various types cancer, such as renal cell carcinoma (RCC). The expression miR-211-5p been detected RCC tissue by microarray profiling. However, studies regarding and remain rare. In present study, tissues lines was revealed to be downregulated reverse transcription-quantitative polymerase chain reaction analyses. results also upregulation or downregulation inhibited promoted,...
Several studies have recently explored the role of microRNAs (miRNAs, miRs) in tumorigenesis various types cancer. miRNAs been reported to be involved numerous cell processes, including apoptosis, proliferation and migration, thus suggesting that may an important cancer progression. Downregulation miR-149-5p has detected RCC tissues by microarray profiling; however, its expression function yet elucidated. In present study, reverse transcription‑quantitative polymerase chain reaction was...
Background Bladder cancer accounts for the most common type of urologic malignancy and presents high recurrence rate after surgical resection adjuvant intravesical therapy. We aim to search an early diagnostic biomarker in serum bladder this study.Methods The expression profiles miRNAs samples 112 patients healthy controls were detected with real-time polymerase chain reaction (RT-qPCR). Receiver operating characteristic (ROC) curve area under (AUC) analysis performed assess efficiency...
Bladder cancer (BC) is one of the ten most common cancers worldwide with late detection and early age diagnosis. There abundant evidence that timely intervention can lead to a better prognosis BC. Substantial has indicated microRNAs (miRNAs) are specific different tumour types remarkably stable, indicating serum miRNAs may serve as potential diagnostic markers. This study aimed identify suitable create panel be used diagnose primary
A direction-oriented spatial interpolation technique for image de-interlacing is presented in this letter. The experimental results demonstrate that our method achieves excellent performance terms of both objective and subjective quality. proposed algorithm also has a very computationally simple structure, proves to be good candidate low-cost hardware interpolator.
<b><i>Introduction:</i></b> The use of ketamine as a recreational drug is on the increase among young adults attending clubs and parties. Recreational users have anecdotally reported increased lower urinary tract symptoms while using substance. <b><i>Methods:</i></b> We describe severe experienced in 6 patients with chronic use. obtained detailed history physical examination along further investigation to identify relationship between these...
High-risk patients with Stage II colon cancer may benefit from adjuvant chemotherapy, but it is difficult to identify such a patient group. A robust and reproducible index would be helpful select the subset of at high risk. This study investigated potential prognostic significance tumour budding in cancer.In all, 135 known outcome were identified. The degree was assessed by two individual observers classified, according number buds area greatest intensity on haematoxylin eosin slides, as...
Renal cell carcinoma (RCC) is a most common kidney malignancy, with atypical symptoms in the early stage and poor outcome late stage. Recently, emerging evidence revealed that some miRNAs play an essential role tumorigenesis progression of RCC. Therefore, aim this study understand detailed molecular mechanism miR-23a-3p RCC identify its potential clinical value.
Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults, which associated with poor prognosis and high recurrence. Long non‑coding RNAs (lncRNAs) have been reported to be dysregulated important regulation carcinogenesis, thus suggesting that this class molecules may used as biomarkers cancer. The lncRNA urothelial 1 (UCA1) has observed upregulated function an oncogene certain types cancer; however, role UCA1 RCC remains elucidated. present study aimed determine...
MicroRNAs (miRNAs/miRs) serve an important role in the regulation of carcinogenic pathways. RCC is most prevalent kidney cancer that occurs adults. miRNAs have gained increasing attention due to their association with tumorigenesis, serving as biomarkers for early detection and progression monitoring, potential targets molecular therapy. Upregulation miRNA-142-3p has been previously identified tissues by microarray profile, however, its expression function not yet validated. In present...
MicroRNAs (miRNAs) are an important class of small, non‑coding RNA molecules that regulate gene expression at the transcriptional or post‑transcriptional level. They involved in apoptosis, proliferation and migration known to have role many types cancer. Aberrant miRNA‑451a (miR‑451a) has previously been reported tumors, however its renal cell carcinoma (RCC) is currently unknown. The aim present study was investigate miR‑451a RCC. analyzed 50 paired RCC normal tissues by quantitative...
microRNAs (miRNAs) are evolutionarily conserved, endogenous, small, noncoding RNA molecules of approximately 22 nucleotides in length that function as post-transcriptional gene regulators. Their aberrant expression may be involved human diseases, including cancer. Although miRNA-184 (miR-184) has been reported other tumors, its renal cell carcinoma (RCC) is still unknown. The aim the present study was to investigate role miR-184 RCC. impacts on migration, proliferation and apoptosis were...
Bladder cancer, the ninth-most-common malignancy worldwide with an estimated 356,000 new cases and 145,000 deaths annually, has a propensity to relapse, requiring lifelong monitoring after diagnosis. 75% patients diagnosed BC are non-muscle invasive over 50% of them experience recurrences within 6-12 years initial miRNA small, noncoding RNA shown be oncogenes or anti-oncogenes in bladder contributing numerous cell processes, including proliferation, differentiation, migration...
MicroRNAs (miRs) are involved in diverse physiological and developmental processes at the post-transcriptional level cells. Previous studies have demonstrated that miR‑136‑5p is certain types of cancer. However, function renal cell carcinoma (RCC) remains to be fully elucidated. In present study, expression levels were determined by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR), MTT assays, CCK‑8 Transwell wound healing assays flow cytometry performed investigate...
microRNAs (miRNAs; miR) are a class of small non-coding RNA molecules, which involved in the pathogenesis human diseases through negative regulation gene expression. Previous studies have demonstrated that miR‑509‑3p is novel miRNA associated with cell proliferation and migration 786‑O renal carcinoma (RCC) cells. However, mechanism action RCC remains to be elucidated. The present study aimed examine functional role development RCC. results expression levels were downregulated ACHN lines...
Renal cell carcinoma (RCC) is the third most common cancer in urological system; however, pathogenesis remains unknown. Accumulating evidence has demonstrated that long non‑coding RNAs are dysregulated various tumors and serves an important role tumorigenesis development. In present study, expression of lncRNA differentiation antagonizing non‑protein coding RNA (DANCR) 24 paired RCC adjacent normal tissues was detected by reverse transcription‑quantitative polymerase chain reaction. The...
Circulating miRNAs have been proved to be promising biomarkers for disease detection in recent years. The present study aimed at exploring available serum miRNA the of colorectal cancer.A three-phase was performed select and validate candidate with significant dysregulation cancer using quantitative reverse transcription-polymerase chain reaction. This recruited 137 patients 145 healthy controls. diagnostic values were evaluated by receiver operating characteristic analysis. Bioinformatics...
Prostate cancer (PCa) remains a worldwide public health problem that poses serious threat to the of men worldwide. Many studies have found microRNA (miRNA) in serum has potential be biomarker for screening. Our study was conducted investigate value miRNAs PCa We selected 12 from past its association with PCa. checked expression levels these 112 patients and healthy controls two-stage experiment. plotted receiver operating characteristic curve validation stage constructed four-miRNA panel...
In adult population, the renal cell carcinoma (RCC) is one of most common urological malignancies. It meaningful to research for molecular markers which are involved in occurrence and development RCC. Therefore, we concentrate on illuminating role microRNA-154-5p progression RCC explore its prognostic values.The real-time quantitative polymerase chain reaction (RT-qPCR) was applied determine expression level miR-154-5p tissues. Afterwards, transfected lines ACHN 786-O were used CCK-8 assay,...
Renal cell carcinoma (RCC) is the most common type of kidney cancer and prognosis metastatic RCC remains poor, with a high rate recurrence mortality. Long non‑coding RNA (lncRNA) class which serves important roles in multiple cellular processes tumorigenesis. In present study, expression function lncRNA eosinophil granule ontogeny transcript (EGOT) were examined RCC. 24 paired tissues (RCC adjacent normal tissues) results reverse transcription‑quantitative polymerase chain reaction analysis...
Urachal carcinomas are rare bladder malignances, which usually present at an advanced stage with a high risk of distant metastases and poor prognosis. To improve understanding this uncommon carcinoma, retrospective review was conducted for the cases observed Peking University Shenzhen Hospital First Hospital. The clinical outcomes were analyzed 17 patients diagnosis urachal cancer, who admitted to (Shenzhen, China) (Beijing, between 1998 2013. TNM staging system used predict outcomes. Among...