Excessive alcohol consumption remains a major public health problem that affects millions of people worldwide. Accumulative experimental evidence has suggested an important involvement gut microbiota in the modulation host's immunological and neurological functions. However, it is previously unknown whether enteric implicated formation withdrawal-induced anxiety. Using murine model chronic alcoholism withdrawal, we examined impact on possible alterations as well anxiety behavior changes. The...

<p dir="ltr">The homeobox (HOX) family has shown potential in adipose development and function, yet the specific HOX proteins fueling thermogenesis remain elusive. In this study, we uncovered novel function of HOXC4 stimulating thermogenesis. Our bioinformatic analysis indicated an enrichment <i>Hoxc4</i> co-expressed genes metabolic pathways linked polymorphisms to parameters, suggesting its involvement regulation. mouse brown tissue, expression negatively correlated with...

Abstract: The current notion that obesity is a major risk factor for the development of and mortality associated with subset liver cancer well appreciated. However, detailed mechanistic insights underlying this relationship are lacking. Better understanding adipose tissue-secreted miRNAs play potential role in defining primary mediating obesity-cancer communication offers new into tumor growth interventions to modulate formation progression. In study, we clearly demonstrated miR-27a more...

Abstract Objectives Signal transducer and activator of transcription 3 (STAT3) is constitutively activated overexpressed in many cancers, including non–small‐cell lung cancer (NSCLC). We recently developed HJC0152 as an orally active STAT3 inhibitor. This study focused on investigating HJC0152's effect mechanism action NSCLC. Materials methods analysed cell proliferation by MTT assays, migration wound healing transwell protein levels Western blot, apoptosis reactive oxygen species (ROS)...

// Zhihua Yin 1,2 , Zhigang Cui 3 Yangwu Ren Lingzi Xia Hang Li and Baosen Zhou 1 Department of Epidemiology, School Public Health, China Medical University, Shenyang, PR 2 Key Laboratory Cancer Etiology Intervention, University Liaoning Province, Nursing, Correspondence to: Yin, email: Zhou, Keywords : lung cancer, microRNA, single nucleotide polymorphism, genetic susceptibility, gene expression Received July 11, 2016 Accepted November 24, Published 30, Abstract This study provides evidence...

Background: MicroRNAs (miRNAs) are suggested to be very important in the development of lung cancer. This study assesses association between polymorphisms miRNA-related (miR)-26a-1, miR-605, and miR-16-1 genes risk cancer, as well effect gene–environment interaction miRNA cooking fume exposure on Methods: A case–control including 268 diagnosed nonsmoking female cancer patients 266 controls was carried out. Three (miR-26a-1 rs7372209, miR-605 rs2043556, rs1022960) were analyzed. Both additive...

Renal cell carcinoma (RCC) is one out of the most universal malignant tumors globally, and its incidence increasing annually. MicroRNA (miRNA) in serum could be considered as a non-invasive detecting biomarker for RCC diagnosis.A total 224 participants (112 patients (RCCs) 112 normal controls (NCs)) were enrolled three-phrase study. Reverse transcription quantitative PCR (RT-qPCR) was applied to reveal miRNA expression levels RCCs NCs. Receiver operating characteristic (ROC) curves area...

Ionizing radiation (IR) is associated with the occurrence of enteritis, and protecting whole intestine from radiation-induced gut injury remains an unmet clinical need. Circulating extracellular vesicles (EVs) are proven to be vital factors in establishment tissue cell microenvironments. In this study, we aimed investigate a radioprotective strategy mediated by small EVs (exosomes) context irradiation-induced intestinal injury. We found that exosomes derived donor mice exposed total body...

Radioresistance is a major problem encountered in the treatment of non-small cell lung cancer (NSCLC). Aberrant microRNA (miRNA) expression contributes to multiple cancer-associated signaling pathways and profoundly influences effects radiotherapy (RT) cancers. MicroRNA-145-5p (miR-145) recognized as tumor suppresser NSCLC. However, roles miR-145 during NSCLC are largely unknown. The present study aimed investigate function underlying mechanism modulation radiosensitivity We generated...

Renal cell carcinoma (RCC), a heterogeneous type of cancer originating from the nephron, occupies approximately 3.9% new carcinomas, with an increasing incidence in past two decades. The most common subtype renal is clear RCC (ccRCC). Though surgery and other treatments are applied to RCC, it has highest recurrence rate mortality among genitourinary cancers. As study progressed, miRNAs found be biomarkers for tumor diagnosis, prognosis targets management.In present study, RT-qPCR, wound...

Lung cancer is known to cause high mortality and morbidity. The study aimed explore the association between rs3733845 rs3733846 polymorphisms in promoter region of miR-143/145 risk lung among 575 nonsmoking cases cancer-free controls a Chinese female population. We genotyped two single nucleotide (SNPs) using TaqMan allelic discrimination method. Logistic regression analysis was conducted assess miR-143/miR-145 females. Crossover used interaction SNPs environmental factors (cooking oil fume...

Given the great success of large language models (LLMs) across various tasks, in this paper, we introduce LLM-ST, a novel and effective speech translation model constructed upon pre-trained LLM. By integrating (LLM) with encoder employing multi-task instruction tuning, LLM-ST can produce accurate timestamped transcriptions translations, even from long audio inputs. Furthermore, our findings indicate that implementation Chain-of-Thought (CoT) prompting yield advantages context LLM-ST. Through...

Rs2292832 is a single nucleotide polymorphism located in the precursor of mir-149 and was reported to be associated with varieties malignancies. So far, effect miR-149 rs2292832 on lung cancer risk unclear. In addition, cooking oil fume exposure demonstrated an important environmental factor Chinese female. The aim present study evaluate associations polymorphism, multiplicative interaction non-smoking female population.The hospital-based case-control conducted females. 555 patients 395...

Abstract Introduction Radioresistance is a major challenge in lung cancer radiotherapy, and new radiosensitizers are urgently needed. Estrogen receptor β (ERβ) involved the progression of non-small cell (NSCLC), however, role ERβ response to radiotherapy remains elusive. In present study, we investigated mechanism underlying ERβ-mediated transcriptional activation radioresistance NSCLC cells. Methods Quantitative real-time PCR, western blot immunohistochemistry were used detect expression...

Background: Renal cell carcinoma (RCC) has been a major health problem and is one of the most malignant tumors around world. Serum microRNA (miRNA) profiles previously have reported as non-invasive biomarkers in cancer screening. The aim this study was to explore serum miRNAs potential for screening RCC. Methods: A three-phase conducted In phase, 12 candidate related RCC were selected further by ENCORI database with 517 patients 71 NCs. total 220 participants [108 112 normal controls (NCs)]...

The diagnosis of renal cell carcinoma (RCC) is often made late since there no early symptom, which thus results in dismal patient prognosis. As a result, new biomarkers are urgently needed and efforts should be to identify their functions predicting RCC microRNAs (miRNAs) class small noncoding RNAs that about 20-22 nucleotides length, they have been demonstrated function as prognostic markers numerous tumors. This study aimed assess the role miR-30b-5p prognosis postoperatively. In this...

Urothelial carcinoma (UCa) is one of the most common malignancies genitourinary system, and early diagnosis vital in improving survival UCa patients. Now, new effective non-invasive markers are urgently needed for UCa. The present study aims to identify miRNAs diagnosis.We enrolled a total 152 patients 135 normal controls at single institution between 2012 2020. expression levels candidate all subjects were calculated from serum samples based on quantitative reverse transcription-polymerase...

The common polymorphism rs11614913 in miR-196a2 might be associated with lung cancer risk for non-smoking females northeast China.The genotypes of were determined by a case-control study including 1003 patients and healthy controls. tissues detected to assess the miRNA expression. Secondary structures predicted.There was significant association between Chinese females. Individuals carrying TC or CC genotype had increased compared TT (adjusted risks 1.63 1.67). C allele higher 1.27. similar...

4th International Symposium on Soil Organic Matter Dynamics6–10 May 2013, Nanjing, ChinaThis conference, attended by 220 international scientists, covered a wide range of studies from nanoparticle characterization soil organic matter (SOM) molecules to ecosystem functions governed the structure and activity SOM, plot monitoring soil–air fluxes simulation modeling continental/global dynamics in context carbon stocks emissions. New SOM were directed understanding processes mechanisms of,...

In this paper, we present Cross Language Agent -- Simultaneous Interpretation, CLASI, a high-quality and human-like Speech Translation (SiST) System. Inspired by professional human interpreters, utilize novel data-driven read-write strategy to balance the translation quality latency. To address challenge of translating in-domain terminologies, CLASI employs multi-modal retrieving module obtain relevant information augment translation. Supported LLMs, our approach can generate error-tolerated...