A5103042279- Autoimmune Bullous Skin Diseases
- Reproductive Biology and Fertility
- Urticaria and Related Conditions
- Pluripotent Stem Cells Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- CRISPR and Genetic Engineering
- Sperm and Testicular Function
- Animal Genetics and Reproduction
- Platelet Disorders and Treatments
- Nail Diseases and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Autoimmune and Inflammatory Disorders
- Oral and gingival health research
- MicroRNA in disease regulation
- Birth, Development, and Health
- Selenium in Biological Systems
- Renal and related cancers
- Mitochondrial Function and Pathology
- Effects and risks of endocrine disrupting chemicals
- Seed and Plant Biochemistry
- Sunflower and Safflower Cultivation
- Eosinophilic Disorders and Syndromes
- Circular RNAs in diseases
- Skin Diseases and Diabetes
- Mesenchymal stem cell research
Jilin Agricultural University
2018-2025
Chinese Academy of Medical Sciences Dermatology Hospital
2018-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Institute of Dermatology
2022
MRC Laboratory of Molecular Biology
2019
Fudan University
2019
Nanjing Medical University
2014-2018
Changzhou No.2 People's Hospital
2014-2018
Jilin University
2015
Yanbian University
2012-2015
Abstract In vitro-cultured oocytes are separated from the follicular micro-environment in vivo and more vulnerable than to changes external environment. This vulnerability disrupts homeostasis of intracellular environment, affecting oocyte meiotic completion, subsequent embryonic developmental competence vitro. Glycine, one main components glutathione (GSH), plays an important role protection porcine However, protective mechanism glycine needs be further clarified. Our results showed that...
Abstract: The current notion that obesity is a major risk factor for the development of and mortality associated with subset liver cancer well appreciated. However, detailed mechanistic insights underlying this relationship are lacking. Better understanding adipose tissue-secreted miRNAs play potential role in defining primary mediating obesity-cancer communication offers new into tumor growth interventions to modulate formation progression. In study, we clearly demonstrated miR-27a more...
Glycine, a component of glutathione (GSH), plays an important role in protection from reactive oxygen species (ROS) and inhibition apoptosis. The aim this study was to determine the effect glycine on vitro maturation (IVM) porcine oocytes their developmental competence after parthenogenetic activation (PA). We examined nuclear maturation, ROS levels, apoptosis, mitochondrial membrane potential (ΔΨm), ATP concentration, as well expression several genes related oocyte development. Our studies...
The endoplasmic reticulum (ER) is a multifunctional organelle in the cytoplasm that plays important roles female mammalian reproduction. and mitochondria interact to maintain normal function of cells by maintaining intracellular calcium homeostasis. As proven previous research, glycine (Gly) can regulate free concentration ([Ca2+]i) enhance mitochondrial improve oocyte maturation vitro. effect Gly on ER during vitro (IVM) not clear. In this study, we induced an stress model with thapsigargin...
Mitochondria play an important role in controlling oocyte developmental competence. Our previous studies showed that glycine (Gly) can regulate mitochondrial function and improve maturation vitro. However, the mechanisms by which Gly affects during vitro have not been fully investigated. In this study, we induced a damage model oocytes with Bcl-2-specific antagonist ABT-199. We investigated whether could reverse dysfunction caused ABT-199 exposure it is related to calcium regulation. results...
Demecolcine (DEM) treatment of oocytes induces formation a membrane protrusion containing mass condensed maternal chromosomes, which can be removed with minimal damage prior to somatic cell nuclear transfer (SCNT). However, the effect this method on distribution maturation-promoting factor (MPF) in porcine has not been reported. Here, level MPF and cyclin B1 were assessed following DEM treatment. In addition, efficiencies DEM-assisted mechanical enucleation compared, as development (in vitro...
The mechanism of livedoid vasculopathy (LV) remains unknown.
The manifestations of bullous pemphigoid (BP) and herpes simplex virus (HSV) infection are similar in oral mucosa, the laboratory detection HSV has some limitations, making it difficult to identify lesions BP. In addition, treatments for BP have contradictory aspects. Thus, is important patients time.
This paper presents a low-cost and efficient method for 3D virtual urban scene reconstruction based on multi-source remote sensing big data deep learning. By integrating maps, satellite optical images, digital terrain model (DTM), the proposed achieves reasonable reconstructed complex urban. The consists of two independent convolutional neural networks (CNN) to process land cover building height extraction. is then tested 100 km <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...
maturation (IVM) of oocytes has been widely used in the field assisted reproductive technology. However, can be injured by oxidative stress during process IVM.
To the Editor: Laboratory diagnostic methods of bullous pemphigoid (BP) include direct immunofluorescence (DIF) microscopy, BP180 NC16A enzyme-linked immunosorbent assays (ELISA), and indirect using salt-split skin (ssIIF) in our daily clinical practice. Immunofluorescence (IF) studies are important parts laboratory workup for BP. DIF is regarded as gold standard BP diagnosis; however, it not specific can also be found other acquired autoimmune subepidermal blistering dermatosis. ssIIF was...
The correlation between IgE anti-BP180 NC16A autoantibody and disease activity of bullous pemphigoid (BP) remains disputable. To determine the levels its clinical significance in untreated BP patients. IgG serum blister fluid samples 34 patients was detected by enzyme-linked immunosorbent assay (ELISA), with pathological features were statistically analysed. Bullous Pemphigoid Disease Area Index (BPDAI) used to measure BP. mean baseline level 75.3 U/mL 1.54 U/mL, respectively (A450, cutoff:...