A5035705032- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Chronic Myeloid Leukemia Treatments
- Virus-based gene therapy research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Polyomavirus and related diseases
- Acute Ischemic Stroke Management
- Chronic Lymphocytic Leukemia Research
- Cerebrovascular and Carotid Artery Diseases
- Immune Cell Function and Interaction
- Reproductive Biology and Fertility
- Inflammatory mediators and NSAID effects
- Bone Metabolism and Diseases
- Lymphoma Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Animal Genetics and Reproduction
- Osteoarthritis Treatment and Mechanisms
- Cytomegalovirus and herpesvirus research
- Childhood Cancer Survivors' Quality of Life
- Parvovirus B19 Infection Studies
- Knee injuries and reconstruction techniques
- Viral-associated cancers and disorders
Beijing Dao Pei Hospital
2009-2024
Harvard Stem Cell Institute
2024
Harvard University
2024
Howard Hughes Medical Institute
2024
Boston Children's Hospital
2024
Dana-Farber Cancer Institute
2024
Luye Pharma (China)
2018-2024
Sun Yat-sen University
2011-2023
Sun Yat-sen University Cancer Center
2011-2023
The Second Affiliated Hospital of Bengbu Medical College
2023
The contourlet transform was proposed as a directional multiresolution image representation that can efficiently capture and represent singularities along smooth object boundaries in natural images. Its efficient filter bank construction well low redundancy make it an attractive computational framework for various processing applications. However, major drawback of the original is its basis images are not localized frequency domain. In this paper, we analyze cause problem, propose new...
Patients often undergo consolidation allogeneic hematopoietic stem cell transplantation (allo-HSCT) to maintain long-term remission following chimeric antigen receptor (CAR) T-cell therapy. Comparisons of safety and efficacy allo-HSCT complete (CR) achieved by CAR-T therapy versus chemotherapy for B-cell acute lymphoblastic leukemia (B-ALL) has not been reported. We performed a parallel comparison transplant outcomes in 105 consecutive B-ALL patients who received after achieving CR with...
Abstract While the use of chimeric antigen receptor‐T (CAR‐T) therapy for T‐cell malignancies is in early stage clinical trials, it exhibits substantial potential to offer long‐term remission patients with refractory/relapsed (R/R) malignancies. In our phase I/II 65 pediatric and adult R/R acute lymphoblastic leukemia lymphoma (T‐ALL/LBL) were enrolled (NCT04572308 NCT04916860). Of these, 60 participants (T‐ALL 35, T‐LBL 25) received a single dose naturally selected anti‐CD7 CAR (NS7CAR) T...
Salvage haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is considered in patients with severe aplastic anemia (SAA) if a matched unrelated donor (MUD) unavailable. However, studies on haplo- and MUD SAA are lacking. The present study retrospectively analyzed the outcomes of 89 young who underwent unmanipulated alternative HSCT between September 2012 2016 at our single center. Forty-one received donors forty-eight MUDs for HSCT. Most were heavily transfused refractory to...
CD7-targeted chimeric antigen receptor T-cell (CAR-T) therapy has shown promising initial complete remission (CR) rates in patients with refractory or relapsed (r/r) acute lymphoblastic leukaemia and lymphoma (T-ALL/LBL). To enhance the duration, consolidation allogeneic haematopoietic stem cell transplantation (allo-HSCT) is considered. Our study delved into outcomes of 34 r/r T-ALL/LBL who underwent allo-HSCT after achieving CR autologous CD7 CAR-T therapy. These were compared 124...
Chimeric antigen receptor (CAR) T-cell therapy has demonstrated high initial complete remission (CR) rates in B-cell acute lymphoblastic leukemia (B-ALL) patients, including those who relapsed after transplant. However, the duration of requires improvements. Whether bridging to a second allogeneic hematopoietic stem cell transplant (allo-HSCT) CAR-T can improve long-term survival remains controversial. We retrospectively analyzed follow-up data B-ALL patients post-transplant and received...
Diffuse large B-cell lymphoma (DLBCL) is a clinically diverse disease. Given the numerous genetic mutations and variations associated with it, prognostic gene signature that can be related to overall survival (OS) clinical implication. We used mRNA expression profiles clinicopathological data of patients DLBCL from Gene Expression Omnibus (GEO) database identify metabolism-related signature. Using LASSO regression analysis, novel 13-metabolic was identified evaluate prognosis. The...
Semaphorin 3A (SEMA3A) and its receptor neuropilin-1 (NRP-1) are expressed low in chondrocytes under stress, overexpressing SEMA3A reduces pro-inflammatory cytokine release. This study was aimed at exploring whether participates lipopolysaccharide (LPS)-induced chondrocyte inflammation, apoptosis extracellular matrix (ECM) degradation. NRP-1 expression LPS-induced ATDC5 cells determined with RT-qPCR western blotting. Following stimulation LPS the absence or presence of overexpression,...
This study investigated the relationship between serum lipid levels and clinical outcomes in acute myeloid leukemia (AML) by establishing a predictive risk classification model.A total of 214 AML patients who were pathologically diagnosed treated with standard induction chemotherapy at Sun Yat-Sen University Cancer Center included. The randomly divided into training (n = 107) validation (n=107) cohorts. Univariate multivariate Cox analyses used to assess value triglyceride (TG),...
Background: Gadolinium enhancement on high resolution magnetic resonance imaging (HR-MRI) has been considered a sign of instability and inflammation intracranial atherosclerotic plaques. Our research objective was to explore the relationship between extent plaque (PE), degree artery stenosis, acute ischemic stroke events.Methods: HR-MRI performed in 91 patients with vascular stenosis determine existence intensity PE.Results: Among enrolled trial, there were 43 acute/subacute group (≤1 month...
Osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is closely associated with diseases. Circular RNAs are reported to be involved in BMSC differentiation. CircSmg5 (circ_0001145) has been identified downregulated an osteoporosis mouse model. In this study, we aimed explore the function and regulatory mechanism circSmg5 osteogenic differentiation.The Alizarin Red staining alkaline phosphatase assays were performed BMSCs. The interaction between circ_0001145, miR-194-5p,...
Directional information is an important and unique feature of multidimensional signals. As a result separable extension from 1D bases, the wavelet transform has very limited directionality. Furthermore, different directions are mixed in certain subbands. In this paper, we propose new that fixes frequency mixing problem by using simple "add-on" to transform. 2D case, it provides one lowpass subband six directional highpass subbands at each scale. Just like transform, proposed nonredundant,...
Abstract Background Osteoarthritis (OA) is a worldwide musculoskeletal disorder. However, disease-modifying therapies for OA are not available. Here, we aimed to characterize the molecular signatures of and identify novel therapeutic targets strategies improve treatment OA. Methods We collected genome-wide transcriptome data performed on 132 74 normal human cartilage or synovium tissues from 7 independent datasets. Differential gene expression analysis functional enrichment were genes...
Introduction We aimed to evaluate prognostic factors of a second allogeneic stem cell transplantation (allo-HSCT2) among hematological malignancy patients who have relapsed after the first allo-HSCT(allo-HSCT1). Methods retrospectively analyzed 199 received allo-HSCT2 as salvage treatment post allo-HSCT1 relapse between November 2012 and October 2021. Results The median age at was 23 (range: 3-60) years. time HSCT1 9 1-72) months. Prior allo-HSCT2, had following hematopoietic...